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Protein

NudC domain-containing protein 2

Gene

Nudcd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.By similarity

GO - Molecular functioni

  • unfolded protein binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
NudC domain-containing protein 2
Gene namesi
Name:Nudcd2
Synonyms:D11Ertd603e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1277103 Nudcd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000579832 – 157NudC domain-containing protein 2Add BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei142PhosphoserineBy similarity1
Modified residuei145PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQ48
MaxQBiQ9CQ48
PaxDbiQ9CQ48
PeptideAtlasiQ9CQ48
PRIDEiQ9CQ48

PTM databases

iPTMnetiQ9CQ48
PhosphoSitePlusiQ9CQ48

Expressioni

Gene expression databases

BgeeiENSMUSG00000020328 Expressed in 284 organ(s), highest expression level in cumulus cell
CleanExiMM_NUDCD2
ExpressionAtlasiQ9CQ48 baseline and differential
GenevisibleiQ9CQ48 MM

Interactioni

Subunit structurei

Interacts with LIS1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CQ48, 1 interactor
MINTiQ9CQ48
STRINGi10090.ENSMUSP00000020578

Structurei

Secondary structure

1157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9CQ48
SMRiQ9CQ48
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CQ48

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 104CSPROSITE-ProRule annotationAdd BLAST91

Phylogenomic databases

eggNOGiKOG2265 Eukaryota
ENOG410XQVU LUCA
GeneTreeiENSGT00390000001644
HOGENOMiHOG000282991
HOVERGENiHBG056555
InParanoidiQ9CQ48
OMAiNREAGNC
OrthoDBiEOG091G0OQY
PhylomeDBiQ9CQ48
TreeFamiTF332391

Family and domain databases

CDDicd06494 p23_NUDCD2_like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR037898 NudC_fam
IPR037902 p23_NUDCD2
PANTHERiPTHR12356 PTHR12356, 1 hit
PfamiView protein in Pfam
PF04969 CS, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CQ48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAPFEERSG VVPCGTPWGQ WYQTLEEVFI EVQVPPGTRA QDIQCGLQSR
60 70 80 90 100
HVALAVGGRE ILKGKLFDST IADEGTWTLE DRKMVRIVLT KTKRDAANCW
110 120 130 140 150
TSLLESEYAA DPWVQDQMQR KLTLERFQKE NPGFDFSGAE ISGNYTKGGP

DFSNLEK
Length:157
Mass (Da):17,660
Last modified:June 1, 2001 - v1
Checksum:iC7F485C957893803
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CYQ2E0CYQ2_MOUSE
NudC domain-containing protein 2
Nudcd2
132Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9S → R in BAB23283 (PubMed:16141072).Curated1
Sequence conflicti9S → R in BAB27222 (PubMed:16141072).Curated1
Sequence conflicti21W → R in BAC27545 (PubMed:16141072).Curated1
Sequence conflicti150P → T in BAB23283 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004388 mRNA Translation: BAB23283.1
AK005909 mRNA Translation: BAB24313.1
AK010850 mRNA Translation: BAB27222.1
AK012388 mRNA Translation: BAB28205.1
AK031779 mRNA Translation: BAC27545.1
AL646055 Genomic DNA No translation available.
BC005646 mRNA Translation: AAH05646.1
CCDSiCCDS24549.1
RefSeqiNP_001277626.1, NM_001290697.1
NP_080299.4, NM_026023.5
UniGeneiMm.276504

Genome annotation databases

EnsembliENSMUST00000020578; ENSMUSP00000020578; ENSMUSG00000020328
GeneIDi52653
KEGGimmu:52653
UCSCiuc007ily.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004388 mRNA Translation: BAB23283.1
AK005909 mRNA Translation: BAB24313.1
AK010850 mRNA Translation: BAB27222.1
AK012388 mRNA Translation: BAB28205.1
AK031779 mRNA Translation: BAC27545.1
AL646055 Genomic DNA No translation available.
BC005646 mRNA Translation: AAH05646.1
CCDSiCCDS24549.1
RefSeqiNP_001277626.1, NM_001290697.1
NP_080299.4, NM_026023.5
UniGeneiMm.276504

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RH0X-ray1.95A/B/C/D5-155[»]
ProteinModelPortaliQ9CQ48
SMRiQ9CQ48
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQ48, 1 interactor
MINTiQ9CQ48
STRINGi10090.ENSMUSP00000020578

PTM databases

iPTMnetiQ9CQ48
PhosphoSitePlusiQ9CQ48

Proteomic databases

EPDiQ9CQ48
MaxQBiQ9CQ48
PaxDbiQ9CQ48
PeptideAtlasiQ9CQ48
PRIDEiQ9CQ48

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020578; ENSMUSP00000020578; ENSMUSG00000020328
GeneIDi52653
KEGGimmu:52653
UCSCiuc007ily.3 mouse

Organism-specific databases

CTDi134492
MGIiMGI:1277103 Nudcd2

Phylogenomic databases

eggNOGiKOG2265 Eukaryota
ENOG410XQVU LUCA
GeneTreeiENSGT00390000001644
HOGENOMiHOG000282991
HOVERGENiHBG056555
InParanoidiQ9CQ48
OMAiNREAGNC
OrthoDBiEOG091G0OQY
PhylomeDBiQ9CQ48
TreeFamiTF332391

Miscellaneous databases

EvolutionaryTraceiQ9CQ48
PROiPR:Q9CQ48
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020328 Expressed in 284 organ(s), highest expression level in cumulus cell
CleanExiMM_NUDCD2
ExpressionAtlasiQ9CQ48 baseline and differential
GenevisibleiQ9CQ48 MM

Family and domain databases

CDDicd06494 p23_NUDCD2_like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR037898 NudC_fam
IPR037902 p23_NUDCD2
PANTHERiPTHR12356 PTHR12356, 1 hit
PfamiView protein in Pfam
PF04969 CS, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUDC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ48
Secondary accession number(s): Q8CD03, Q9CY63, Q9D0V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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