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Protein

Dynein regulatory complex protein 8

Gene

Efcab2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex protein 8By similarity
Alternative name(s):
EF-hand calcium-binding domain-containing protein 2
Gene namesi
Name:Efcab2
Synonyms:Drc8By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915476 Efcab2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535451 – 164Dynein regulatory complex protein 8Add BLAST164

Proteomic databases

PaxDbiQ9CQ46
PRIDEiQ9CQ46

PTM databases

iPTMnetiQ9CQ46
PhosphoSitePlusiQ9CQ46

Expressioni

Gene expression databases

BgeeiENSMUSG00000026495 Expressed in 225 organ(s), highest expression level in testis
CleanExiMM_EFCAB2
GenevisibleiQ9CQ46 MM

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027775

Structurei

3D structure databases

ProteinModelPortaliQ9CQ46
SMRiQ9CQ46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 51EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini94 – 129EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the DRC8 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00670000097718
HOGENOMiHOG000233018
HOVERGENiHBG103834
InParanoidiQ9CQ46
OMAiLLMERKM
OrthoDBiEOG091G0UVL
PhylomeDBiQ9CQ46
TreeFamiTF324069

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9CQ46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEERDAEGT EALIAELHKK IKDAFEVFDH ESNNTVDVRE IGTIIRSLGC
60 70 80 90 100
CPTEGELHDF IAEIEEEEPT GYIRFEKFIP VMTRALVERR YRPAAEDILL
110 120 130 140 150
RAFEVLDPAK RGFLTKDELV KYMTEEGEPF SQEEMEEMLS AAIDPESNTI
160
NYRDYITMMV VDEN
Length:164
Mass (Da):18,929
Last modified:June 1, 2001 - v1
Checksum:iC8AF058D07F53E1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010880 mRNA Translation: BAB27243.1
AK015157 mRNA Translation: BAB29727.1
AK018894 mRNA Translation: BAB31477.1
AK019663 mRNA Translation: BAB31827.1
AK019802 mRNA Translation: BAB31856.1
BC025062 mRNA Translation: AAH25062.1
CCDSiCCDS15557.1
RefSeqiNP_080902.1, NM_026626.2
UniGeneiMm.252132

Genome annotation databases

EnsembliENSMUST00000027775; ENSMUSP00000027775; ENSMUSG00000026495
GeneIDi68226
KEGGimmu:68226
UCSCiuc007dve.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010880 mRNA Translation: BAB27243.1
AK015157 mRNA Translation: BAB29727.1
AK018894 mRNA Translation: BAB31477.1
AK019663 mRNA Translation: BAB31827.1
AK019802 mRNA Translation: BAB31856.1
BC025062 mRNA Translation: AAH25062.1
CCDSiCCDS15557.1
RefSeqiNP_080902.1, NM_026626.2
UniGeneiMm.252132

3D structure databases

ProteinModelPortaliQ9CQ46
SMRiQ9CQ46
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027775

PTM databases

iPTMnetiQ9CQ46
PhosphoSitePlusiQ9CQ46

Proteomic databases

PaxDbiQ9CQ46
PRIDEiQ9CQ46

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027775; ENSMUSP00000027775; ENSMUSG00000026495
GeneIDi68226
KEGGimmu:68226
UCSCiuc007dve.1 mouse

Organism-specific databases

CTDi84288
MGIiMGI:1915476 Efcab2

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00670000097718
HOGENOMiHOG000233018
HOVERGENiHBG103834
InParanoidiQ9CQ46
OMAiLLMERKM
OrthoDBiEOG091G0UVL
PhylomeDBiQ9CQ46
TreeFamiTF324069

Miscellaneous databases

PROiPR:Q9CQ46
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026495 Expressed in 225 organ(s), highest expression level in testis
CleanExiMM_EFCAB2
GenevisibleiQ9CQ46 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDRC8_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ46
Secondary accession number(s): Q9CS07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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