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Protein

DNA polymerase epsilon subunit 4

Gene

Pole4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-110314 Recognition of DNA damage by PCNA-containing replication complex
R-MMU-174430 Telomere C-strand synthesis initiation
R-MMU-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-MMU-5656169 Termination of translesion DNA synthesis
R-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-MMU-5696400 Dual Incision in GG-NER
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-68952 DNA replication initiation
R-MMU-68962 Activation of the pre-replicative complex

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase epsilon subunit 4 (EC:2.7.7.7)
Alternative name(s):
DNA polymerase II subunit 4
DNA polymerase epsilon subunit p12
Gene namesi
Name:Pole4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914229 Pole4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001917472 – 118DNA polymerase epsilon subunit 4Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei11PhosphothreonineBy similarity1
Modified residuei25PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQ36
MaxQBiQ9CQ36
PaxDbiQ9CQ36
PRIDEiQ9CQ36

2D gel databases

REPRODUCTION-2DPAGEiQ9CQ36

PTM databases

iPTMnetiQ9CQ36
PhosphoSitePlusiQ9CQ36

Expressioni

Gene expression databases

BgeeiENSMUSG00000030042
ExpressionAtlasiQ9CQ36 baseline and differential
GenevisibleiQ9CQ36 MM

Interactioni

Subunit structurei

Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE3 is a prerequisite for further binding with POLE and POLE2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093462

Structurei

3D structure databases

ProteinModelPortaliQ9CQ36
SMRiQ9CQ36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG1658 Eukaryota
ENOG41122NU LUCA
GeneTreeiENSGT00530000063560
HOGENOMiHOG000007271
HOVERGENiHBG051399
InParanoidiQ9CQ36
KOiK03506
PhylomeDBiQ9CQ36
TreeFamiTF103009

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQ36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAGSG TPREEEAPGG EAAASQAQAP TSAPGGVRLS RLPLARVKAL
60 70 80 90 100
VKADPDVTLA GQEAIFILAR AAELFVETIA KDAYCCAQQG KRKTLQRRDL
110
DNAIEAVDEF AFLEGTLD
Length:118
Mass (Da):12,240
Last modified:June 1, 2001 - v1
Checksum:iCE6B47CD7BC93A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010135 mRNA Translation: BAB26722.1
AK010300 mRNA Translation: BAB26833.1
AK011595 mRNA Translation: BAB27723.1
AK160582 mRNA Translation: BAE35889.1
AK167631 mRNA Translation: BAE39682.1
BC023189 mRNA Translation: AAH23189.1
CCDSiCCDS39524.1
RefSeqiNP_080158.1, NM_025882.3
UniGeneiMm.195753

Genome annotation databases

EnsembliENSMUST00000095786; ENSMUSP00000093462; ENSMUSG00000030042
GeneIDi66979
KEGGimmu:66979
UCSCiuc009clk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDPOE4_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ36
Secondary accession number(s): Q3TJ13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health