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Protein

DNA polymerase epsilon subunit 4

Gene

Pole4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-110314 Recognition of DNA damage by PCNA-containing replication complex
R-MMU-174430 Telomere C-strand synthesis initiation
R-MMU-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-MMU-5656169 Termination of translesion DNA synthesis
R-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-MMU-5696400 Dual Incision in GG-NER
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-68952 DNA replication initiation
R-MMU-68962 Activation of the pre-replicative complex

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase epsilon subunit 4 (EC:2.7.7.7)
Alternative name(s):
DNA polymerase II subunit 4
DNA polymerase epsilon subunit p12
Gene namesi
Name:Pole4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914229 Pole4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001917472 – 118DNA polymerase epsilon subunit 4Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei11PhosphothreonineBy similarity1
Modified residuei25PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQ36
MaxQBiQ9CQ36
PaxDbiQ9CQ36
PRIDEiQ9CQ36

2D gel databases

REPRODUCTION-2DPAGEiQ9CQ36

PTM databases

iPTMnetiQ9CQ36
PhosphoSitePlusiQ9CQ36

Expressioni

Gene expression databases

BgeeiENSMUSG00000030042 Expressed in 303 organ(s), highest expression level in embryo
ExpressionAtlasiQ9CQ36 baseline and differential
GenevisibleiQ9CQ36 MM

Interactioni

Subunit structurei

Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE3 is a prerequisite for further binding with POLE and POLE2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-2109 epsilon DNA polymerase complex
STRINGi10090.ENSMUSP00000093462

Structurei

3D structure databases

ProteinModelPortaliQ9CQ36
SMRiQ9CQ36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG1658 Eukaryota
ENOG41122NU LUCA
GeneTreeiENSGT00530000063560
HOGENOMiHOG000007271
HOVERGENiHBG051399
InParanoidiQ9CQ36
KOiK03506
PhylomeDBiQ9CQ36
TreeFamiTF103009

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CQ36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAAAGSG TPREEEAPGG EAAASQAQAP TSAPGGVRLS RLPLARVKAL
60 70 80 90 100
VKADPDVTLA GQEAIFILAR AAELFVETIA KDAYCCAQQG KRKTLQRRDL
110
DNAIEAVDEF AFLEGTLD
Length:118
Mass (Da):12,240
Last modified:June 1, 2001 - v1
Checksum:iCE6B47CD7BC93A09
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CYA9E0CYA9_MOUSE
DNA polymerase epsilon subunit 4
Pole4
119Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010135 mRNA Translation: BAB26722.1
AK010300 mRNA Translation: BAB26833.1
AK011595 mRNA Translation: BAB27723.1
AK160582 mRNA Translation: BAE35889.1
AK167631 mRNA Translation: BAE39682.1
BC023189 mRNA Translation: AAH23189.1
CCDSiCCDS39524.1
RefSeqiNP_080158.1, NM_025882.3
UniGeneiMm.195753

Genome annotation databases

EnsembliENSMUST00000095786; ENSMUSP00000093462; ENSMUSG00000030042
GeneIDi66979
KEGGimmu:66979
UCSCiuc009clk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010135 mRNA Translation: BAB26722.1
AK010300 mRNA Translation: BAB26833.1
AK011595 mRNA Translation: BAB27723.1
AK160582 mRNA Translation: BAE35889.1
AK167631 mRNA Translation: BAE39682.1
BC023189 mRNA Translation: AAH23189.1
CCDSiCCDS39524.1
RefSeqiNP_080158.1, NM_025882.3
UniGeneiMm.195753

3D structure databases

ProteinModelPortaliQ9CQ36
SMRiQ9CQ36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2109 epsilon DNA polymerase complex
STRINGi10090.ENSMUSP00000093462

PTM databases

iPTMnetiQ9CQ36
PhosphoSitePlusiQ9CQ36

2D gel databases

REPRODUCTION-2DPAGEiQ9CQ36

Proteomic databases

EPDiQ9CQ36
MaxQBiQ9CQ36
PaxDbiQ9CQ36
PRIDEiQ9CQ36

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095786; ENSMUSP00000093462; ENSMUSG00000030042
GeneIDi66979
KEGGimmu:66979
UCSCiuc009clk.1 mouse

Organism-specific databases

CTDi56655
MGIiMGI:1914229 Pole4

Phylogenomic databases

eggNOGiKOG1658 Eukaryota
ENOG41122NU LUCA
GeneTreeiENSGT00530000063560
HOGENOMiHOG000007271
HOVERGENiHBG051399
InParanoidiQ9CQ36
KOiK03506
PhylomeDBiQ9CQ36
TreeFamiTF103009

Enzyme and pathway databases

ReactomeiR-MMU-110314 Recognition of DNA damage by PCNA-containing replication complex
R-MMU-174430 Telomere C-strand synthesis initiation
R-MMU-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-MMU-5656169 Termination of translesion DNA synthesis
R-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-MMU-5696400 Dual Incision in GG-NER
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-68952 DNA replication initiation
R-MMU-68962 Activation of the pre-replicative complex

Miscellaneous databases

ChiTaRSiPole4 mouse
PROiPR:Q9CQ36
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030042 Expressed in 303 organ(s), highest expression level in embryo
ExpressionAtlasiQ9CQ36 baseline and differential
GenevisibleiQ9CQ36 MM

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPOE4_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ36
Secondary accession number(s): Q3TJ13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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