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Protein

STAM-binding protein

Gene

Stambp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (By similarity). Involved in the ubiquitin-dependent sorting and trafficking of receptors from endosomes to lysosome. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Activity regulationi

Inhibited by N-ethylmaleimide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei280Indirect zinc-bindingBy similarity1
Metal bindingi335Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi337Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi348Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi350Zinc 2By similarity1
Metal bindingi390Zinc 2By similarity1
Metal bindingi396Zinc 2By similarity1
Metal bindingi398Zinc 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5689901 Metalloprotease DUBs

Protein family/group databases

MEROPSiM67.006

Names & Taxonomyi

Protein namesi
Recommended name:
STAM-binding protein (EC:3.4.19.-)
Alternative name(s):
Associated molecule with the SH3 domain of STAM
Gene namesi
Name:Stambp
Synonyms:Amsh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1917777 Stambp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show a loss of neurons and apoptotic cells in the hippocampus.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001948701 – 424STAM-binding proteinAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei48PhosphoserineBy similarity1
Modified residuei243PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated after BMP type I receptor activation.By similarity
Ubiquitinated by SMURF2 in the presence of RNF11.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CQ26
MaxQBiQ9CQ26
PaxDbiQ9CQ26
PRIDEiQ9CQ26

PTM databases

iPTMnetiQ9CQ26
PhosphoSitePlusiQ9CQ26
SwissPalmiQ9CQ26

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Developmental stagei

Highest expression at E18.5, followed by a gradual decrease.1 Publication

Gene expression databases

BgeeiENSMUSG00000006906 Expressed in 256 organ(s), highest expression level in testis
CleanExiMM_STAMBP
GenevisibleiQ9CQ26 MM

Interactioni

Subunit structurei

Interacts with STAM. Interacts with SMAD6 and SMAD7. Interacts with CHMP3; the interaction appears to relieve the autoinhibition of CHMP3 (By similarity). Interacts with SMURF2 and RNF11; this interaction promotes ubiquitination (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070876

Structurei

3D structure databases

ProteinModelPortaliQ9CQ26
SMRiQ9CQ26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini257 – 388MPNPROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 127Interaction with CHMP3By similarityAdd BLAST127
Regioni227 – 231Interaction with STAM1By similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi335 – 348JAMM motifPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 177Glu-richAdd BLAST74

Domaini

The JAMM motif is essential for the protease activity.By similarity

Sequence similaritiesi

Belongs to the peptidase M67C family.Curated

Phylogenomic databases

eggNOGiKOG2880 Eukaryota
COG1310 LUCA
GeneTreeiENSGT00930000150927
HOGENOMiHOG000195792
HOVERGENiHBG058519
InParanoidiQ9CQ26
KOiK11866
OMAiCNTMHEE
OrthoDBiEOG091G06CJ
PhylomeDBiQ9CQ26
TreeFamiTF323215

Family and domain databases

InterProiView protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR015063 USP8_dimer
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF08969 USP8_dimer, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQ26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDHGDVSLP PQDRVRILSQ LGSAVELNED IPPRRYYRSG VEIIRMASVY
60 70 80 90 100
SEEGNIEHAF ILYNKYITLF IEKLPKHRDY KSAIIPEKKD AVKKLKSVAF
110 120 130 140 150
PKAEELKTEL LRRYTKEYEQ YKERKKKEEE ELARNIAIQQ ELEKEKQRVA
160 170 180 190 200
QQKQKQLEQE QFHAFEEMIQ RQELEKERLK IVQEFGKVDP GPCGPLLPDL
210 220 230 240 250
EKPCVDVAPS SPFSPTQTPD CNTGMRPAKP PVVDRSLKPG ALSVIENVPT
260 270 280 290 300
IEGLRHIVVP RNLCSEFLQL ASANTAKGIE TCGVLCGKLM RNEFTITHVL
310 320 330 340 350
IPRQNGGPDY CHTENEEEIF FMQDDLGLLT LGWIHTHPTQ TAFLSSVDLH
360 370 380 390 400
THCSYQMMLP ESIAIVCSPK FQETGFFKLT DYGLQEISTC RQKGFHPHGR
410 420
DPPLFCDCSH VTVKDRIVTI TDLR
Length:424
Mass (Da):48,514
Last modified:June 1, 2001 - v1
Checksum:iD3A9C2B5F65B7C5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010123 mRNA Translation: BAB78604.1
AK017600 mRNA Translation: BAB30832.1
AK019907 mRNA Translation: BAB31909.1
AK136961 mRNA Translation: BAE23188.1
AK139391 mRNA Translation: BAE23991.1
BC003497 mRNA Translation: AAH03497.1
BC006939 mRNA Translation: AAH06939.1
BC025111 mRNA Translation: AAH25111.1
CCDSiCCDS20280.1
RefSeqiNP_077201.1, NM_024239.2
XP_006506646.1, XM_006506583.2
XP_006506647.1, XM_006506584.2
XP_006506648.1, XM_006506585.1
UniGeneiMm.32801

Genome annotation databases

EnsembliENSMUST00000068054; ENSMUSP00000070876; ENSMUSG00000006906
ENSMUST00000206400; ENSMUSP00000145871; ENSMUSG00000006906
ENSMUST00000206592; ENSMUSP00000146294; ENSMUSG00000006906
GeneIDi70527
KEGGimmu:70527
UCSCiuc009cns.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010123 mRNA Translation: BAB78604.1
AK017600 mRNA Translation: BAB30832.1
AK019907 mRNA Translation: BAB31909.1
AK136961 mRNA Translation: BAE23188.1
AK139391 mRNA Translation: BAE23991.1
BC003497 mRNA Translation: AAH03497.1
BC006939 mRNA Translation: AAH06939.1
BC025111 mRNA Translation: AAH25111.1
CCDSiCCDS20280.1
RefSeqiNP_077201.1, NM_024239.2
XP_006506646.1, XM_006506583.2
XP_006506647.1, XM_006506584.2
XP_006506648.1, XM_006506585.1
UniGeneiMm.32801

3D structure databases

ProteinModelPortaliQ9CQ26
SMRiQ9CQ26
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070876

Protein family/group databases

MEROPSiM67.006

PTM databases

iPTMnetiQ9CQ26
PhosphoSitePlusiQ9CQ26
SwissPalmiQ9CQ26

Proteomic databases

EPDiQ9CQ26
MaxQBiQ9CQ26
PaxDbiQ9CQ26
PRIDEiQ9CQ26

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068054; ENSMUSP00000070876; ENSMUSG00000006906
ENSMUST00000206400; ENSMUSP00000145871; ENSMUSG00000006906
ENSMUST00000206592; ENSMUSP00000146294; ENSMUSG00000006906
GeneIDi70527
KEGGimmu:70527
UCSCiuc009cns.1 mouse

Organism-specific databases

CTDi10617
MGIiMGI:1917777 Stambp

Phylogenomic databases

eggNOGiKOG2880 Eukaryota
COG1310 LUCA
GeneTreeiENSGT00930000150927
HOGENOMiHOG000195792
HOVERGENiHBG058519
InParanoidiQ9CQ26
KOiK11866
OMAiCNTMHEE
OrthoDBiEOG091G06CJ
PhylomeDBiQ9CQ26
TreeFamiTF323215

Enzyme and pathway databases

ReactomeiR-MMU-5689901 Metalloprotease DUBs

Miscellaneous databases

PROiPR:Q9CQ26
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006906 Expressed in 256 organ(s), highest expression level in testis
CleanExiMM_STAMBP
GenevisibleiQ9CQ26 MM

Family and domain databases

InterProiView protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR015063 USP8_dimer
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF08969 USP8_dimer, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTABP_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ26
Secondary accession number(s): Q3UTI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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