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Entry version 121 (08 May 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Malignant T-cell-amplified sequence 2

Gene

Mcts2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Imprinted gene expressed from the paternal allele in blastocysts.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Malignant T-cell-amplified sequence 2
Short name:
MCT-2
Alternative name(s):
Multiple copies T-cell malignancies 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mcts2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913655 Mcts2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003447881 – 181Malignant T-cell-amplified sequence 2Add BLAST181

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9CQ21

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CQ21

PeptideAtlas

More...
PeptideAtlasi
Q9CQ21

PRoteomics IDEntifications database

More...
PRIDEi
Q9CQ21

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9CQ21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042814 Expressed in 268 organ(s), highest expression level in midbrain

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CQ21 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000100534

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9CQ21

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 171PUAPROSITE-ProRule annotationAdd BLAST80

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly through interaction with other proteins.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MCTS1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2523 Eukaryota
COG2016 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074964

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000223988

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CQ21

Identification of Orthologs from Complete Genome Data

More...
OMAi
GAHMMCP

Database of Orthologous Groups

More...
OrthoDBi
1257440at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CQ21

TreeFam database of animal gene trees

More...
TreeFami
TF315123

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016437 MCT-1/Tma20
IPR041366 Pre-PUA
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR004521 Uncharacterised_CHP00451

The PANTHER Classification System

More...
PANTHERi
PTHR22798 PTHR22798, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17832 Pre-PUA, 1 hit
PF01472 PUA, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005067 Tma_RNA-bind_prd, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00359 PUA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF88697 SSF88697, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00451 unchar_dom_2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50890 PUA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9CQ21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKKFDEKES VSNCIQLKTS VIKGIKSQLT EQFPGIEPWL NQIMPKKDPV
60 70 80 90 100
KIVRCHEHME ILTVNGELLF FRQRKGPFYP TLRLLHKYPF ILPHQQVDKG
110 120 130 140 150
AIKFVLSGAN IMCPGLTSPG AKLYTAAVDT IVAVMAEGKE HALCVGVMKM
160 170 180
AAADIEKINK GIGIENIHYL NDGLWHMKTY K
Length:181
Mass (Da):20,437
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD549F69DE8E693C2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK002563 mRNA Translation: BAB22189.1
AK010255 mRNA Translation: BAB26798.1
AK028001 mRNA Translation: BAC25695.1
AL845162 Genomic DNA No translation available.
BC027507 mRNA Translation: AAH27507.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38281.1

NCBI Reference Sequences

More...
RefSeqi
NP_079819.1, NM_025543.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000062148; ENSMUSP00000100534; ENSMUSG00000042814

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66405

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:66405

UCSC genome browser

More...
UCSCi
uc008nge.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002563 mRNA Translation: BAB22189.1
AK010255 mRNA Translation: BAB26798.1
AK028001 mRNA Translation: BAC25695.1
AL845162 Genomic DNA No translation available.
BC027507 mRNA Translation: AAH27507.1
CCDSiCCDS38281.1
RefSeqiNP_079819.1, NM_025543.2

3D structure databases

SMRiQ9CQ21
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100534

PTM databases

SwissPalmiQ9CQ21

Proteomic databases

MaxQBiQ9CQ21
PaxDbiQ9CQ21
PeptideAtlasiQ9CQ21
PRIDEiQ9CQ21

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062148; ENSMUSP00000100534; ENSMUSG00000042814
GeneIDi66405
KEGGimmu:66405
UCSCiuc008nge.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
66405
MGIiMGI:1913655 Mcts2

Phylogenomic databases

eggNOGiKOG2523 Eukaryota
COG2016 LUCA
GeneTreeiENSGT00550000074964
HOGENOMiHOG000223988
InParanoidiQ9CQ21
OMAiGAHMMCP
OrthoDBi1257440at2759
PhylomeDBiQ9CQ21
TreeFamiTF315123

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9CQ21

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042814 Expressed in 268 organ(s), highest expression level in midbrain
GenevisibleiQ9CQ21 MM

Family and domain databases

Gene3Di2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR016437 MCT-1/Tma20
IPR041366 Pre-PUA
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR004521 Uncharacterised_CHP00451
PANTHERiPTHR22798 PTHR22798, 1 hit
PfamiView protein in Pfam
PF17832 Pre-PUA, 1 hit
PF01472 PUA, 1 hit
PIRSFiPIRSF005067 Tma_RNA-bind_prd, 1 hit
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00451 unchar_dom_2, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCTS2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CQ21
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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