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Protein

Ribonuclease H2 subunit C

Gene

Rnaseh2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H2 subunit C
Short name:
RNase H2 subunit C
Alternative name(s):
Ribonuclease HI subunit C
Gene namesi
Name:Rnaseh2c
Synonyms:Ayp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1915459 Rnaseh2c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002483861 – 166Ribonuclease H2 subunit CAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CQ18
MaxQBiQ9CQ18
PaxDbiQ9CQ18
PeptideAtlasiQ9CQ18
PRIDEiQ9CQ18

PTM databases

iPTMnetiQ9CQ18
PhosphoSitePlusiQ9CQ18

Expressioni

Gene expression databases

BgeeiENSMUSG00000024925 Expressed in 278 organ(s), highest expression level in ear vesicle
CleanExiMM_RNASEH2C
ExpressionAtlasiQ9CQ18 baseline and differential
GenevisibleiQ9CQ18 MM

Interactioni

Subunit structurei

The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025864

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9CQ18
SMRiQ9CQ18
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CQ18

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase H2 subunit C family.Curated

Phylogenomic databases

eggNOGiENOG410J0SE Eukaryota
ENOG41126TY LUCA
GeneTreeiENSGT00390000001568
HOGENOMiHOG000230780
HOVERGENiHBG093917
InParanoidiQ9CQ18
KOiK10745
OMAiRGYPLMG
OrthoDBiEOG091G0TLU
PhylomeDBiQ9CQ18
TreeFamiTF324370

Family and domain databases

CDDicd09271 RNase_H2-C, 1 hit
InterProiView protein in InterPro
IPR013924 RNase_H2_suC
PfamiView protein in Pfam
PF08615 RNase_H2_suC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CQ18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNPEEAADG KQRIHLRPGS LRGAAPAKLH LLPCDVLVSR PAPVDRFFTP
60 70 80 90 100
AVRHDADGLQ ASFRGRGLRG EEVAVPPGFA GFVMVTEEKG EGLIGKLNFS
110 120 130 140 150
GDAEDKADEA QEPLERDFDR LIGATGSFSH FTLWGLETVP GPDAKVHRAL
160
GWPSLAAAIH AQVPED
Length:166
Mass (Da):17,823
Last modified:June 1, 2001 - v1
Checksum:iD631CFE252040417
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZDT4F6ZDT4_MOUSE
Ribonuclease H2 subunit C
Rnaseh2c
88Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9D → E in AAH24333 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346604 mRNA Translation: AAO49175.1
AK018776 mRNA Translation: BAB31401.1
AK011556 mRNA Translation: BAB27694.1
BC024333 mRNA Translation: AAH24333.1
CCDSiCCDS29471.1
RefSeqiNP_080892.1, NM_026616.2
UniGeneiMm.246200

Genome annotation databases

EnsembliENSMUST00000025864; ENSMUSP00000025864; ENSMUSG00000024925
GeneIDi68209
KEGGimmu:68209
UCSCiuc008gdx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346604 mRNA Translation: AAO49175.1
AK018776 mRNA Translation: BAB31401.1
AK011556 mRNA Translation: BAB27694.1
BC024333 mRNA Translation: AAH24333.1
CCDSiCCDS29471.1
RefSeqiNP_080892.1, NM_026616.2
UniGeneiMm.246200

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KIOX-ray2.90C1-166[»]
3P5JX-ray2.90C1-166[»]
ProteinModelPortaliQ9CQ18
SMRiQ9CQ18
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025864

PTM databases

iPTMnetiQ9CQ18
PhosphoSitePlusiQ9CQ18

Proteomic databases

EPDiQ9CQ18
MaxQBiQ9CQ18
PaxDbiQ9CQ18
PeptideAtlasiQ9CQ18
PRIDEiQ9CQ18

Protocols and materials databases

DNASUi68209
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025864; ENSMUSP00000025864; ENSMUSG00000024925
GeneIDi68209
KEGGimmu:68209
UCSCiuc008gdx.1 mouse

Organism-specific databases

CTDi84153
MGIiMGI:1915459 Rnaseh2c

Phylogenomic databases

eggNOGiENOG410J0SE Eukaryota
ENOG41126TY LUCA
GeneTreeiENSGT00390000001568
HOGENOMiHOG000230780
HOVERGENiHBG093917
InParanoidiQ9CQ18
KOiK10745
OMAiRGYPLMG
OrthoDBiEOG091G0TLU
PhylomeDBiQ9CQ18
TreeFamiTF324370

Miscellaneous databases

EvolutionaryTraceiQ9CQ18
PROiPR:Q9CQ18
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024925 Expressed in 278 organ(s), highest expression level in ear vesicle
CleanExiMM_RNASEH2C
ExpressionAtlasiQ9CQ18 baseline and differential
GenevisibleiQ9CQ18 MM

Family and domain databases

CDDicd09271 RNase_H2-C, 1 hit
InterProiView protein in InterPro
IPR013924 RNase_H2_suC
PfamiView protein in Pfam
PF08615 RNase_H2_suC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNH2C_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ18
Secondary accession number(s): Q8R1N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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