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Protein

COMM domain-containing protein 4

Gene

Commd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B.By similarity

Keywordsi

Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 4
Gene namesi
Name:Commd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1913449 Commd4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000773941 – 199COMM domain-containing protein 4Add BLAST199

Proteomic databases

EPDiQ9CQ02
MaxQBiQ9CQ02
PaxDbiQ9CQ02
PeptideAtlasiQ9CQ02
PRIDEiQ9CQ02

PTM databases

iPTMnetiQ9CQ02
PhosphoSitePlusiQ9CQ02

Expressioni

Gene expression databases

BgeeiENSMUSG00000032299 Expressed in 283 organ(s), highest expression level in bone marrow
CleanExiMM_COMMD4
ExpressionAtlasiQ9CQ02 baseline and differential
GenevisibleiQ9CQ02 MM

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL5, CUL7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069078

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 199COMMPROSITE-ProRule annotationAdd BLAST70

Phylogenomic databases

eggNOGiENOG410IEAM Eukaryota
ENOG4111EZM LUCA
GeneTreeiENSGT00390000015516
HOGENOMiHOG000006594
HOVERGENiHBG051069
InParanoidiQ9CQ02
KOiK22560
OMAiVSWRVDY
OrthoDBiEOG091G0O71
PhylomeDBiQ9CQ02
TreeFamiTF317482

Family and domain databases

CDDicd04752 Commd4, 1 hit
InterProiView protein in InterPro
IPR017920 COMM
IPR037356 Commd4
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9CQ02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFRFCGDLD CPDWVLAEIS TLAKISSVKL RLLCSQVLKE LLGQGIDYEK
60 70 80 90 100
ILKLTADAKF ESGDVKATVA VLSFILSSAA KHSVDSDSLS SELQQLGLPK
110 120 130 140 150
EHATSLCRCY EEKQSPLQEH LRACSLRVNR LASVGWRVDY TLSSSLLHSV
160 170 180 190
EEPMVHLQLQ VVPAPGTQAQ PVSMSLSADK FQVLLAELKQ AQTMMTALG
Length:199
Mass (Da):21,860
Last modified:June 1, 2001 - v1
Checksum:iE07656167DAEAFA4
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SRJ9A0A1L1SRJ9_MOUSE
COMM domain-containing protein 4
Commd4
129Annotation score:
A0A1L1SVC7A0A1L1SVC7_MOUSE
COMM domain-containing protein 4
Commd4
180Annotation score:
A0A1L1SRX4A0A1L1SRX4_MOUSE
COMM domain-containing protein 4
Commd4
164Annotation score:
A0A1L1SRM6A0A1L1SRM6_MOUSE
COMM domain-containing protein 4
Commd4
82Annotation score:
A0A1L1STT5A0A1L1STT5_MOUSE
COMM domain-containing protein 4
Commd4
54Annotation score:
A0A1L1ST08A0A1L1ST08_MOUSE
COMM domain-containing protein 4
Commd4
96Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009802 mRNA Translation: BAB26512.1
AK004174 mRNA Translation: BAB23207.1
BC033438 mRNA Translation: AAH33438.1
BC049222 mRNA Translation: AAH49222.1
CCDSiCCDS40647.1
RefSeqiNP_079693.1, NM_025417.2
UniGeneiMm.41687

Genome annotation databases

EnsembliENSMUST00000065358; ENSMUSP00000069078; ENSMUSG00000032299
GeneIDi66199
KEGGimmu:66199
UCSCiuc009pul.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009802 mRNA Translation: BAB26512.1
AK004174 mRNA Translation: BAB23207.1
BC033438 mRNA Translation: AAH33438.1
BC049222 mRNA Translation: AAH49222.1
CCDSiCCDS40647.1
RefSeqiNP_079693.1, NM_025417.2
UniGeneiMm.41687

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069078

PTM databases

iPTMnetiQ9CQ02
PhosphoSitePlusiQ9CQ02

Proteomic databases

EPDiQ9CQ02
MaxQBiQ9CQ02
PaxDbiQ9CQ02
PeptideAtlasiQ9CQ02
PRIDEiQ9CQ02

Protocols and materials databases

DNASUi66199
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065358; ENSMUSP00000069078; ENSMUSG00000032299
GeneIDi66199
KEGGimmu:66199
UCSCiuc009pul.1 mouse

Organism-specific databases

CTDi54939
MGIiMGI:1913449 Commd4

Phylogenomic databases

eggNOGiENOG410IEAM Eukaryota
ENOG4111EZM LUCA
GeneTreeiENSGT00390000015516
HOGENOMiHOG000006594
HOVERGENiHBG051069
InParanoidiQ9CQ02
KOiK22560
OMAiVSWRVDY
OrthoDBiEOG091G0O71
PhylomeDBiQ9CQ02
TreeFamiTF317482

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation

Miscellaneous databases

ChiTaRSiCommd4 mouse
PROiPR:Q9CQ02
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032299 Expressed in 283 organ(s), highest expression level in bone marrow
CleanExiMM_COMMD4
ExpressionAtlasiQ9CQ02 baseline and differential
GenevisibleiQ9CQ02 MM

Family and domain databases

CDDicd04752 Commd4, 1 hit
InterProiView protein in InterPro
IPR017920 COMM
IPR037356 Commd4
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOMD4_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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