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Entry version 156 (02 Dec 2020)
Sequence version 3 (23 Jan 2007)
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Protein

Cytosol aminopeptidase

Gene

Lap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytolosic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn2+ ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn2+, it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.By similarity EC:3.4.11.1
  • Release of N-terminal proline from a peptide.By similarity EC:3.4.11.5

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarity, Mn2+By similarityNote: Binds two metal ions per subunit. Two metal binding sites with different affinities are located in the enzyme active site and can be occupied in vitro by different metals: site 1 is occupied by Zn2+, Mn2+, Mg2+ or Co2+, while the tight binding site 2 can be occupied by only Zn2+ or Co2+. One Zn2+ ion is tightly bound to site 2 and essential for enzyme activity in vivo, while site 1 can be occupied by different metals to give different enzymatic activities. Mn2+ is required for Cys-Gly hydrolysis activity. A third metal binding site may serve a structural role, possibly stabilizing part of the interface between the N-terminal and the catalytic domain.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi202Zinc 3; via carbonyl oxygen; structuralBy similarity1
Metal bindingi203Zinc 3; via carbonyl oxygen; structuralBy similarity1
Metal bindingi282Zinc 2; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei282SubstrateBy similarity1
Metal bindingi287Zinc 1 or magnesium; catalyticBy similarity1
Metal bindingi287Zinc 2; catalyticBy similarity1
Binding sitei287SubstrateBy similarity1
Binding sitei292SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei294By similarity1
Binding sitei294SubstrateBy similarity1
Metal bindingi303Zinc 3; via carbonyl oxygen; structuralBy similarity1
Metal bindingi305Zinc 2; catalyticBy similarity1
Binding sitei305SubstrateBy similarity1
Metal bindingi364Zinc 1 or magnesium; catalyticBy similarity1
Binding sitei364SubstrateBy similarity1
Metal bindingi366Zinc 1 or magnesium; catalyticBy similarity1
Metal bindingi366Zinc 2; catalyticBy similarity1
Active sitei368By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandMagnesium, Manganese, Metal-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M17.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosol aminopeptidaseCurated (EC:3.4.11.1By similarity)
Alternative name(s):
Cysteinylglycine-S-conjugate dipeptidaseBy similarity (EC:3.4.13.23By similarity)
Leucine aminopeptidase 3Imported
Short name:
LAP-3
Leucyl aminopeptidaseImported
Peptidase SImported
Proline aminopeptidaseBy similarity (EC:3.4.11.5By similarity)
Prolyl aminopeptidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lap3Imported
Synonyms:Lapep
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914238, Lap3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001658261 – 519Cytosol aminopeptidaseAdd BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45N6-succinyllysineCombined sources1
Modified residuei54PhosphoserineBy similarity1
Modified residuei61N6-succinyllysineCombined sources1
Modified residuei103N6-succinyllysineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei194PhosphoserineBy similarity1
Modified residuei221N6-acetyllysine; alternateCombined sources1
Modified residuei221N6-succinyllysine; alternateCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei455N6-acetyllysine; alternateCombined sources1
Modified residuei455N6-succinyllysine; alternateCombined sources1
Modified residuei476N6-succinyllysineCombined sources1
Modified residuei489N6-acetyllysine; alternateCombined sources1
Modified residuei489N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3688
non-CPTAC-3689

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9CPY7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CPY7

PeptideAtlas

More...
PeptideAtlasi
Q9CPY7

PRoteomics IDEntifications database

More...
PRIDEi
Q9CPY7

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00828469

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9CPY7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9CPY7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9CPY7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039682, Expressed in white adipose tissue and 326 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CPY7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
211856, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q9CPY7, 5 interactors

Molecular INTeraction database

More...
MINTi
Q9CPY7

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000040222

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9CPY7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9CPY7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M17 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2597, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063255

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013734_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CPY7

Identification of Orthologs from Complete Genome Data

More...
OMAi
MKNTGPR

Database of Orthologous Groups

More...
OrthoDBi
562530at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CPY7

TreeFam database of animal gene trees

More...
TreeFami
TF314954

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00433, Peptidase_M17, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.220.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00181, Cytosol_peptidase_M17, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011356, Leucine_aapep/pepB
IPR043472, Macro_dom-like
IPR000819, Peptidase_M17_C
IPR023042, Peptidase_M17_leu_NH2_pept
IPR008283, Peptidase_M17_N

The PANTHER Classification System

More...
PANTHERi
PTHR11963, PTHR11963, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00883, Peptidase_M17, 1 hit
PF02789, Peptidase_M17_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00481, LAMNOPPTDASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52949, SSF52949, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00631, CYTOSOL_AP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CPY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYLLPLPAAA RVALRRLGVR GLWDRGLSTA DMTKGLVLGI YAKDKDDDLP
60 70 80 90 100
QFTSAGESFN KLVSGKLREM LNISGPPLKA GKTRTFYGLH QDFPSVVVVG
110 120 130 140 150
LGKRSAGVDD QENWHEGKEN IRAAVAAGCR QVQDLELPSV EVDPCGDAQA
160 170 180 190 200
AAEGAVLGLY EYDDLKQKKK VAVSAKLHGS GDLEAWEKGV LFASGQNLAR
210 220 230 240 250
HLMESPANEM TPTRFAEIIE KNLKSASSKT KVHIRPKSWI EEQEMGSFLS
260 270 280 290 300
VAKGSEEPPV FLEIHYMGSP NATEAPLVFV GKGITFDSGG ISIKASANMD
310 320 330 340 350
LMRADMGGAA TICSAIVSAA KLNLPINIIG LAPLCENMPS GKANKPGDVV
360 370 380 390 400
RARNGKTIQV DNTDAEGRLI LADALCYAHT FNPKVIINAA TLTGAMDVAL
410 420 430 440 450
GSGATGVFTN SSWLWNKLFE ASVETGDRVW RMPLFEHYTR QVIDCQLADV
460 470 480 490 500
NNLGKYRSAG ACTAAAFLRE FVTHTKWAHL DIAGVMTNKD EIPYLRKGMS
510
GRPTRTLIEF LLRFSKDSS
Length:519
Mass (Da):56,141
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46729A9CE4C060A5
GO
Isoform 2 (identifier: Q9CPY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:488
Mass (Da):52,750
Checksum:iE6800977EC37A2AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JEM7A0A0G2JEM7_MOUSE
Cytosol aminopeptidase
Lap3
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB23958 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB25769 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB27726 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE39141 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE40823 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46D → G in CAJ18509 (Ref. 2) Curated1
Sequence conflicti93F → L in CAJ18445 (Ref. 2) Curated1
Sequence conflicti123A → D in BAB26987 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0226321 – 31Missing in isoform 2. CuratedAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF334160 mRNA Translation: AAK13495.1
CT010237 mRNA Translation: CAJ18445.1
CT010301 mRNA Translation: CAJ18509.1
AK002819 mRNA No translation available.
AK005334 mRNA Translation: BAB23958.1 Different initiation.
AK008600 mRNA Translation: BAB25769.1 Different initiation.
AK010502 mRNA Translation: BAB26987.1
AK011604 mRNA Translation: BAB27726.1 Different initiation.
AK166958 mRNA Translation: BAE39141.1 Different initiation.
AK169032 mRNA Translation: BAE40823.1 Different initiation.
BC016536 mRNA Translation: AAH16536.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19274.1 [Q9CPY7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_077754.3, NM_024434.6 [Q9CPY7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000046122; ENSMUSP00000040222; ENSMUSG00000039682 [Q9CPY7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
66988

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:66988

UCSC genome browser

More...
UCSCi
uc008xiy.2, mouse [Q9CPY7-1]

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334160 mRNA Translation: AAK13495.1
CT010237 mRNA Translation: CAJ18445.1
CT010301 mRNA Translation: CAJ18509.1
AK002819 mRNA No translation available.
AK005334 mRNA Translation: BAB23958.1 Different initiation.
AK008600 mRNA Translation: BAB25769.1 Different initiation.
AK010502 mRNA Translation: BAB26987.1
AK011604 mRNA Translation: BAB27726.1 Different initiation.
AK166958 mRNA Translation: BAE39141.1 Different initiation.
AK169032 mRNA Translation: BAE40823.1 Different initiation.
BC016536 mRNA Translation: AAH16536.1
CCDSiCCDS19274.1 [Q9CPY7-1]
RefSeqiNP_077754.3, NM_024434.6 [Q9CPY7-1]

3D structure databases

SMRiQ9CPY7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi211856, 20 interactors
IntActiQ9CPY7, 5 interactors
MINTiQ9CPY7
STRINGi10090.ENSMUSP00000040222

Protein family/group databases

MEROPSiM17.001

PTM databases

iPTMnetiQ9CPY7
PhosphoSitePlusiQ9CPY7
SwissPalmiQ9CPY7

2D gel databases

REPRODUCTION-2DPAGEiIPI00828469

Proteomic databases

CPTACinon-CPTAC-3688
non-CPTAC-3689
jPOSTiQ9CPY7
PaxDbiQ9CPY7
PeptideAtlasiQ9CPY7
PRIDEiQ9CPY7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23080, 229 antibodies

Genome annotation databases

EnsembliENSMUST00000046122; ENSMUSP00000040222; ENSMUSG00000039682 [Q9CPY7-1]
GeneIDi66988
KEGGimmu:66988
UCSCiuc008xiy.2, mouse [Q9CPY7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51056
MGIiMGI:1914238, Lap3

Phylogenomic databases

eggNOGiKOG2597, Eukaryota
GeneTreeiENSGT00530000063255
HOGENOMiCLU_013734_1_2_1
InParanoidiQ9CPY7
OMAiMKNTGPR
OrthoDBi562530at2759
PhylomeDBiQ9CPY7
TreeFamiTF314954

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
66988, 4 hits in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Lap3, mouse

Protein Ontology

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PROi
PR:Q9CPY7
RNActiQ9CPY7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000039682, Expressed in white adipose tissue and 326 other tissues
GenevisibleiQ9CPY7, MM

Family and domain databases

CDDicd00433, Peptidase_M17, 1 hit
Gene3Di3.40.220.10, 1 hit
HAMAPiMF_00181, Cytosol_peptidase_M17, 1 hit
InterProiView protein in InterPro
IPR011356, Leucine_aapep/pepB
IPR043472, Macro_dom-like
IPR000819, Peptidase_M17_C
IPR023042, Peptidase_M17_leu_NH2_pept
IPR008283, Peptidase_M17_N
PANTHERiPTHR11963, PTHR11963, 1 hit
PfamiView protein in Pfam
PF00883, Peptidase_M17, 1 hit
PF02789, Peptidase_M17_N, 1 hit
PRINTSiPR00481, LAMNOPPTDASE
SUPFAMiSSF52949, SSF52949, 1 hit
PROSITEiView protein in PROSITE
PS00631, CYTOSOL_AP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMPL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CPY7
Secondary accession number(s): Q3TFS5
, Q4FJV1, Q4FK15, Q99P44, Q9CWN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 23, 2007
Last modified: December 2, 2020
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
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