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Protein

Translocon-associated protein subunit beta

Gene

Ssr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit beta
Short name:
TRAP-beta
Alternative name(s):
Signal sequence receptor subunit beta
Short name:
SSR-beta
Gene namesi
Name:Ssr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913506 Ssr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 146LumenalSequence analysisAdd BLAST129
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 183CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17By similarityAdd BLAST17
ChainiPRO_000003329118 – 183Translocon-associated protein subunit betaAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) (high mannose) asparagine2 Publications1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9CPW5
PaxDbiQ9CPW5
PeptideAtlasiQ9CPW5
PRIDEiQ9CPW5
TopDownProteomicsiQ9CPW5

PTM databases

iPTMnetiQ9CPW5
PhosphoSitePlusiQ9CPW5
UniCarbKBiQ9CPW5

Expressioni

Gene expression databases

BgeeiENSMUSG00000041355 Expressed in 302 organ(s), highest expression level in dorsal pancreas
CleanExiMM_SSR2
ExpressionAtlasiQ9CPW5 baseline and differential
GenevisibleiQ9CPW5 MM

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045456

Structurei

3D structure databases

ProteinModelPortaliQ9CPW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAP-beta family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3317 Eukaryota
ENOG4111KGI LUCA
GeneTreeiENSGT00390000005125
HOGENOMiHOG000007980
HOVERGENiHBG000858
InParanoidiQ9CPW5
KOiK13250
OMAiDNGFHPE
PhylomeDBiQ9CPW5
TreeFamiTF314461

Family and domain databases

InterProiView protein in InterPro
IPR008856 TRAP_beta
PIRSFiPIRSF016400 TRAP_beta, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9CPW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLAVVVLA LLAVSQAEEG ARLLASKSLL NRYAVEGRDL TLQYNIYNVG
60 70 80 90 100
SSAALDVELS DDSFPPEDFG IVSGMLNVKW DRIAPASNVS HTVVLRPLKA
110 120 130 140 150
GYFNFTSATI TYLAQEDGPV VIGSTSAPGQ GGILAQREFD RRFSPHFLDW
160 170 180
AAFGVMTLPS IGIPLLLWYS SKRKYDTPKP KKN
Length:183
Mass (Da):20,019
Last modified:June 1, 2001 - v1
Checksum:iEFC743A84F02A4AF
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YXB7A0A0A6YXB7_MOUSE
Translocon-associated protein subun...
Ssr2
185Annotation score:
A0A0A6YVZ1A0A0A6YVZ1_MOUSE
Signal sequence receptor, beta, iso...
Ssr2 mCG_8842
164Annotation score:
A0A0A6YW45A0A0A6YW45_MOUSE
Translocon-associated protein subun...
Ssr2
34Annotation score:
A0A0A6YWA8A0A0A6YWA8_MOUSE
Translocon-associated protein subun...
Ssr2
117Annotation score:
A0A0A6YWL0A0A0A6YWL0_MOUSE
Translocon-associated protein subun...
Ssr2
32Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132G → E in BAB32009 (PubMed:16141072).Curated1
Sequence conflicti163I → M in AAH10214 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005340 mRNA Translation: BAB23962.1
AK007538 mRNA Translation: BAB25097.1
AK007720 mRNA Translation: BAB25211.1
AK010565 mRNA Translation: BAB27030.1
AK020145 mRNA Translation: BAB32009.1
AK050505 mRNA Translation: BAC34295.1
AK084530 mRNA Translation: BAC39212.1
BC010214 mRNA Translation: AAH10214.1
CCDSiCCDS17480.1
RefSeqiNP_079724.1, NM_025448.3
XP_006501941.1, XM_006501878.2
UniGeneiMm.486239
Mm.7091

Genome annotation databases

EnsembliENSMUST00000035785; ENSMUSP00000045456; ENSMUSG00000041355
ENSMUST00000195014; ENSMUSP00000141441; ENSMUSG00000041355
GeneIDi66256
KEGGimmu:66256
UCSCiuc008pvs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005340 mRNA Translation: BAB23962.1
AK007538 mRNA Translation: BAB25097.1
AK007720 mRNA Translation: BAB25211.1
AK010565 mRNA Translation: BAB27030.1
AK020145 mRNA Translation: BAB32009.1
AK050505 mRNA Translation: BAC34295.1
AK084530 mRNA Translation: BAC39212.1
BC010214 mRNA Translation: AAH10214.1
CCDSiCCDS17480.1
RefSeqiNP_079724.1, NM_025448.3
XP_006501941.1, XM_006501878.2
UniGeneiMm.486239
Mm.7091

3D structure databases

ProteinModelPortaliQ9CPW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045456

PTM databases

iPTMnetiQ9CPW5
PhosphoSitePlusiQ9CPW5
UniCarbKBiQ9CPW5

Proteomic databases

MaxQBiQ9CPW5
PaxDbiQ9CPW5
PeptideAtlasiQ9CPW5
PRIDEiQ9CPW5
TopDownProteomicsiQ9CPW5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035785; ENSMUSP00000045456; ENSMUSG00000041355
ENSMUST00000195014; ENSMUSP00000141441; ENSMUSG00000041355
GeneIDi66256
KEGGimmu:66256
UCSCiuc008pvs.1 mouse

Organism-specific databases

CTDi6746
MGIiMGI:1913506 Ssr2

Phylogenomic databases

eggNOGiKOG3317 Eukaryota
ENOG4111KGI LUCA
GeneTreeiENSGT00390000005125
HOGENOMiHOG000007980
HOVERGENiHBG000858
InParanoidiQ9CPW5
KOiK13250
OMAiDNGFHPE
PhylomeDBiQ9CPW5
TreeFamiTF314461

Miscellaneous databases

ChiTaRSiSsr2 mouse
PROiPR:Q9CPW5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041355 Expressed in 302 organ(s), highest expression level in dorsal pancreas
CleanExiMM_SSR2
ExpressionAtlasiQ9CPW5 baseline and differential
GenevisibleiQ9CPW5 MM

Family and domain databases

InterProiView protein in InterPro
IPR008856 TRAP_beta
PIRSFiPIRSF016400 TRAP_beta, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSSRB_MOUSE
AccessioniPrimary (citable) accession number: Q9CPW5
Secondary accession number(s): Q91Z43, Q9CR94, Q9CX54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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