Arpc5

Functionⁱ

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).By similarity

GO - Molecular functionⁱ

actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
structural constituent of cytoskeleton Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament network formation Source: MGI
Arp2/3 complex-mediated actin nucleation Source: MGI
cell migration Source: MGI
lamellipodium organization Source: MGI
maintenance of cell polarity Source: MGI
microtubule organizing center localization Source: MGI
orbitofrontal cortex development Source: Ensembl
smooth muscle cell migration Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding

Molecular function

Actin-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation R-MMU-3928662 EPHB-mediated forward signaling R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs R-MMU-6798695 Neutrophil degranulation R-MMU-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-6798695 Neutrophil degranulation
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Actin-related protein 2/3 complex subunit 5 Alternative name(s): Arp2/3 complex 16 kDa subunit Short name: p16-ARC
Gene namesⁱ	Name:Arpc5
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1915021 Arpc5

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000124055	2 – 151	Actin-related protein 2/3 complex subunit 5Add BLAST		150

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineBy similarity		1

Post-translational modificationⁱ

Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.By similarity

Keywords - PTMⁱ

Acetylation, Ubl conjugation

Proteomic databases

EPDⁱ	Q9CPW4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9CPW4
PaxDbⁱ	Q9CPW4
PRIDEⁱ	Q9CPW4
TopDownProteomicsⁱ	Q9CPW4

PTM databases

iPTMnetⁱ	Q9CPW4
PhosphoSitePlusⁱ	Q9CPW4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000008475 Expressed in 275 organ(s), highest expression level in stroma of bone marrow
CleanExⁱ	MM_ARPC5
ExpressionAtlasⁱ	Q9CPW4 baseline and differential
Genevisibleⁱ	Q9CPW4 MM

Interactionⁱ

Subunit structureⁱ

Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functionⁱ

actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	212431, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-60589N
IntActⁱ	Q9CPW4, 3 interactors
STRINGⁱ	10090.ENSMUSP00000076933

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9CPW4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3380 Eukaryota ENOG4111FGV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014806
HOGENOMⁱ	HOG000197215
HOVERGENⁱ	HBG050583
InParanoidⁱ	Q9CPW4
KEGG Orthology (KO) More...KOⁱ	K05754
OMAⁱ	GCIVRAM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R2J
PhylomeDBⁱ	Q9CPW4
TreeFamⁱ	TF319716

Family and domain databases

Gene3Dⁱ	1.25.40.190, 1 hit
InterProⁱ	View protein in InterPro IPR006789 ARPC5 IPR036743 ARPC5_sf
PANTHERⁱ	PTHR12644 PTHR12644, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04699 P16-Arc, 1 hit
PIRSFⁱ	PIRSF039096 p16-ARC, 1 hit
SUPFAMⁱ	SSF69103 SSF69103, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9CPW4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN 
        60         70         80         90        100
MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK 
       110        120        130        140        150
NGVDLLMKYI YKGFESPSDN SSAVLLQWHE KALAAGGVGS IVRVLTARKT 

V

Length:151

Mass (Da):16,288

Last modified:January 23, 2007 - v3

Checksum:ⁱF050B10DC5416E66

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q3UA72	Q3UA72_MOUSE		Actin-related protein 2/3 complex s... Actin-related protein 2/3 complex subunit 5	Arpc5	92	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	59	L → Q in BAB25457 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK008097 mRNA Translation: BAB25457.1 AK011348 mRNA Translation: BAB27558.1 AK011911 mRNA Translation: BAB27911.1 AK017669 mRNA Translation: BAB30864.1 AK019149 mRNA Translation: BAB31570.1 AK087427 mRNA Translation: BAC39870.1 AK149756 mRNA Translation: BAE29064.1 AK151654 mRNA Translation: BAE30583.1 AK151656 mRNA Translation: BAE30585.1 AK152281 mRNA Translation: BAE31095.1 AK153262 mRNA Translation: BAE31852.1 AK159407 mRNA Translation: BAE35058.1 AK159438 mRNA Translation: BAE35084.1 AK159738 mRNA Translation: BAE35332.1 AK166284 mRNA Translation: BAE38681.1 AK166335 mRNA Translation: BAE38714.1 AK166725 mRNA Translation: BAE38972.1 AK167916 mRNA Translation: BAE39923.1 AK168264 mRNA Translation: BAE40212.1 AK168986 mRNA Translation: BAE40786.1 BC060143 mRNA Translation: AAH60143.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35739.1
NCBI Reference Sequences More...RefSeqⁱ	NP_080645.2, NM_026369.2
UniGeneⁱ	Mm.288974

Genome annotation databases

Ensemblⁱ	ENSMUST00000077755; ENSMUSP00000076933; ENSMUSG00000008475
GeneIDⁱ	67771
KEGGⁱ	mmu:67771
UCSC genome browser More...UCSCⁱ	uc007czj.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9CPW4	Actin-related protein 2/3 complex subunit 5		MACMU		151	UniRef100_Q9CPW4
Actin-related protein 2/3 complex subunit 5		MACFA		151
Actin-related protein 2/3 complex subunit 5		Cebus capucinus imitator		151
Actin-related protein 2/3 complex subunit 5		MUSPF		151
Actin-related protein 2/3 complex subunit 5		ODORO		151
+13

Protein	Similar proteins		Species	Score	Length	Source
Q9CPW4	Actin-related protein 2/3 complex subunit 5		HUMAN		151	UniRef90_O15511
Actin-related protein 2/3 complex subunit 5		PONAB		151
Actin-related protein 2/3 complex subunit 5		RAT		151
Actin-related protein 2/3 complex subunit 5	)	BOVIN		151
Actin-related protein 2/3 complex subunit 5		CALJA		151
+120

Protein	Similar proteins		Species	Score	Length	Source
Q9CPW4	Actin-related protein 2/3 complex subunit 5		HUMAN		151	UniRef50_O15511
Actin-related protein 2/3 complex subunit 5		PONAB		151
Actin-related protein 2/3 complex subunit 5		RAT		151
Actin-related protein 2/3 complex subunit 5	)	BOVIN		151
Actin-related protein 2/3 complex subunit 5		CALJA		151
+134

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK008097 mRNA Translation: BAB25457.1 AK011348 mRNA Translation: BAB27558.1 AK011911 mRNA Translation: BAB27911.1 AK017669 mRNA Translation: BAB30864.1 AK019149 mRNA Translation: BAB31570.1 AK087427 mRNA Translation: BAC39870.1 AK149756 mRNA Translation: BAE29064.1 AK151654 mRNA Translation: BAE30583.1 AK151656 mRNA Translation: BAE30585.1 AK152281 mRNA Translation: BAE31095.1 AK153262 mRNA Translation: BAE31852.1 AK159407 mRNA Translation: BAE35058.1 AK159438 mRNA Translation: BAE35084.1 AK159738 mRNA Translation: BAE35332.1 AK166284 mRNA Translation: BAE38681.1 AK166335 mRNA Translation: BAE38714.1 AK166725 mRNA Translation: BAE38972.1 AK167916 mRNA Translation: BAE39923.1 AK168264 mRNA Translation: BAE40212.1 AK168986 mRNA Translation: BAE40786.1 BC060143 mRNA Translation: AAH60143.1
CCDSⁱ	CCDS35739.1
RefSeqⁱ	NP_080645.2, NM_026369.2
UniGeneⁱ	Mm.288974

3D structure databases

ProteinModelPortalⁱ	Q9CPW4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	212431, 1 interactor
DIPⁱ	DIP-60589N
IntActⁱ	Q9CPW4, 3 interactors
STRINGⁱ	10090.ENSMUSP00000076933

PTM databases

iPTMnetⁱ	Q9CPW4
PhosphoSitePlusⁱ	Q9CPW4

Proteomic databases

EPDⁱ	Q9CPW4
MaxQBⁱ	Q9CPW4
PaxDbⁱ	Q9CPW4
PRIDEⁱ	Q9CPW4
TopDownProteomicsⁱ	Q9CPW4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000077755; ENSMUSP00000076933; ENSMUSG00000008475
GeneIDⁱ	67771
KEGGⁱ	mmu:67771
UCSCⁱ	uc007czj.2 mouse

Organism-specific databases

CTDⁱ	10092
MGIⁱ	MGI:1915021 Arpc5

Phylogenomic databases

eggNOGⁱ	KOG3380 Eukaryota ENOG4111FGV LUCA
GeneTreeⁱ	ENSGT00390000014806
HOGENOMⁱ	HOG000197215
HOVERGENⁱ	HBG050583
InParanoidⁱ	Q9CPW4
KOⁱ	K05754
OMAⁱ	GCIVRAM
OrthoDBⁱ	EOG091G0R2J
PhylomeDBⁱ	Q9CPW4
TreeFamⁱ	TF319716

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation R-MMU-3928662 EPHB-mediated forward signaling R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs R-MMU-6798695 Neutrophil degranulation R-MMU-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-6798695 Neutrophil degranulation
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSⁱ	Arpc5 mouse
Protein Ontology More...PROⁱ	PR:Q9CPW4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000008475 Expressed in 275 organ(s), highest expression level in stroma of bone marrow
CleanExⁱ	MM_ARPC5
ExpressionAtlasⁱ	Q9CPW4 baseline and differential
Genevisibleⁱ	Q9CPW4 MM

Family and domain databases

Gene3Dⁱ	1.25.40.190, 1 hit
InterProⁱ	View protein in InterPro IPR006789 ARPC5 IPR036743 ARPC5_sf
PANTHERⁱ	PTHR12644 PTHR12644, 1 hit
Pfamⁱ	View protein in Pfam PF04699 P16-Arc, 1 hit
PIRSFⁱ	PIRSF039096 p16-ARC, 1 hit
SUPFAMⁱ	SSF69103 SSF69103, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARPC5_MOUSE
Accessionⁱ	Q9CPW4Primary (citable) accession number: Q9CPW4 Secondary accession number(s): Q3U9T3, Q9D8E7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - Q9CPW4 (ARPC5_MOUSE)

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Actin-related protein 2/3 complex subunit 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Endosome

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ