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Protein

Actin-related protein 2/3 complex subunit 5

Gene

Arpc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).By similarity

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • structural constituent of cytoskeleton Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-6798695 Neutrophil degranulation
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
Gene namesi
Name:Arpc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915021 Arpc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001240552 – 151Actin-related protein 2/3 complex subunit 5Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Post-translational modificationi

Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiQ9CPW4
MaxQBiQ9CPW4
PaxDbiQ9CPW4
PRIDEiQ9CPW4
TopDownProteomicsiQ9CPW4

PTM databases

iPTMnetiQ9CPW4
PhosphoSitePlusiQ9CPW4

Expressioni

Gene expression databases

BgeeiENSMUSG00000008475 Expressed in 275 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_ARPC5
ExpressionAtlasiQ9CPW4 baseline and differential
GenevisibleiQ9CPW4 MM

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212431, 1 interactor
DIPiDIP-60589N
IntActiQ9CPW4, 3 interactors
STRINGi10090.ENSMUSP00000076933

Structurei

3D structure databases

ProteinModelPortaliQ9CPW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGiKOG3380 Eukaryota
ENOG4111FGV LUCA
GeneTreeiENSGT00390000014806
HOGENOMiHOG000197215
HOVERGENiHBG050583
InParanoidiQ9CPW4
KOiK05754
OMAiGCIVRAM
OrthoDBiEOG091G0R2J
PhylomeDBiQ9CPW4
TreeFamiTF319716

Family and domain databases

Gene3Di1.25.40.190, 1 hit
InterProiView protein in InterPro
IPR006789 ARPC5
IPR036743 ARPC5_sf
PANTHERiPTHR12644 PTHR12644, 1 hit
PfamiView protein in Pfam
PF04699 P16-Arc, 1 hit
PIRSFiPIRSF039096 p16-ARC, 1 hit
SUPFAMiSSF69103 SSF69103, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CPW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN
60 70 80 90 100
MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK
110 120 130 140 150
NGVDLLMKYI YKGFESPSDN SSAVLLQWHE KALAAGGVGS IVRVLTARKT

V
Length:151
Mass (Da):16,288
Last modified:January 23, 2007 - v3
Checksum:iF050B10DC5416E66
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UA72Q3UA72_MOUSE
Actin-related protein 2/3 complex s...
Arpc5
92Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59L → Q in BAB25457 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008097 mRNA Translation: BAB25457.1
AK011348 mRNA Translation: BAB27558.1
AK011911 mRNA Translation: BAB27911.1
AK017669 mRNA Translation: BAB30864.1
AK019149 mRNA Translation: BAB31570.1
AK087427 mRNA Translation: BAC39870.1
AK149756 mRNA Translation: BAE29064.1
AK151654 mRNA Translation: BAE30583.1
AK151656 mRNA Translation: BAE30585.1
AK152281 mRNA Translation: BAE31095.1
AK153262 mRNA Translation: BAE31852.1
AK159407 mRNA Translation: BAE35058.1
AK159438 mRNA Translation: BAE35084.1
AK159738 mRNA Translation: BAE35332.1
AK166284 mRNA Translation: BAE38681.1
AK166335 mRNA Translation: BAE38714.1
AK166725 mRNA Translation: BAE38972.1
AK167916 mRNA Translation: BAE39923.1
AK168264 mRNA Translation: BAE40212.1
AK168986 mRNA Translation: BAE40786.1
BC060143 mRNA Translation: AAH60143.1
CCDSiCCDS35739.1
RefSeqiNP_080645.2, NM_026369.2
UniGeneiMm.288974

Genome annotation databases

EnsembliENSMUST00000077755; ENSMUSP00000076933; ENSMUSG00000008475
GeneIDi67771
KEGGimmu:67771
UCSCiuc007czj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008097 mRNA Translation: BAB25457.1
AK011348 mRNA Translation: BAB27558.1
AK011911 mRNA Translation: BAB27911.1
AK017669 mRNA Translation: BAB30864.1
AK019149 mRNA Translation: BAB31570.1
AK087427 mRNA Translation: BAC39870.1
AK149756 mRNA Translation: BAE29064.1
AK151654 mRNA Translation: BAE30583.1
AK151656 mRNA Translation: BAE30585.1
AK152281 mRNA Translation: BAE31095.1
AK153262 mRNA Translation: BAE31852.1
AK159407 mRNA Translation: BAE35058.1
AK159438 mRNA Translation: BAE35084.1
AK159738 mRNA Translation: BAE35332.1
AK166284 mRNA Translation: BAE38681.1
AK166335 mRNA Translation: BAE38714.1
AK166725 mRNA Translation: BAE38972.1
AK167916 mRNA Translation: BAE39923.1
AK168264 mRNA Translation: BAE40212.1
AK168986 mRNA Translation: BAE40786.1
BC060143 mRNA Translation: AAH60143.1
CCDSiCCDS35739.1
RefSeqiNP_080645.2, NM_026369.2
UniGeneiMm.288974

3D structure databases

ProteinModelPortaliQ9CPW4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212431, 1 interactor
DIPiDIP-60589N
IntActiQ9CPW4, 3 interactors
STRINGi10090.ENSMUSP00000076933

PTM databases

iPTMnetiQ9CPW4
PhosphoSitePlusiQ9CPW4

Proteomic databases

EPDiQ9CPW4
MaxQBiQ9CPW4
PaxDbiQ9CPW4
PRIDEiQ9CPW4
TopDownProteomicsiQ9CPW4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077755; ENSMUSP00000076933; ENSMUSG00000008475
GeneIDi67771
KEGGimmu:67771
UCSCiuc007czj.2 mouse

Organism-specific databases

CTDi10092
MGIiMGI:1915021 Arpc5

Phylogenomic databases

eggNOGiKOG3380 Eukaryota
ENOG4111FGV LUCA
GeneTreeiENSGT00390000014806
HOGENOMiHOG000197215
HOVERGENiHBG050583
InParanoidiQ9CPW4
KOiK05754
OMAiGCIVRAM
OrthoDBiEOG091G0R2J
PhylomeDBiQ9CPW4
TreeFamiTF319716

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-6798695 Neutrophil degranulation
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSiArpc5 mouse
PROiPR:Q9CPW4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008475 Expressed in 275 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_ARPC5
ExpressionAtlasiQ9CPW4 baseline and differential
GenevisibleiQ9CPW4 MM

Family and domain databases

Gene3Di1.25.40.190, 1 hit
InterProiView protein in InterPro
IPR006789 ARPC5
IPR036743 ARPC5_sf
PANTHERiPTHR12644 PTHR12644, 1 hit
PfamiView protein in Pfam
PF04699 P16-Arc, 1 hit
PIRSFiPIRSF039096 p16-ARC, 1 hit
SUPFAMiSSF69103 SSF69103, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARPC5_MOUSE
AccessioniPrimary (citable) accession number: Q9CPW4
Secondary accession number(s): Q3U9T3, Q9D8E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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