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Protein

P2Y purinoceptor 12

Gene

P2ry12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99ADPBy similarity1
Binding sitei103ADP; via carbonyl oxygenBy similarity1
Binding sitei111ADPBy similarity1
Binding sitei193ADPBy similarity1
Binding sitei197ADPBy similarity1
Binding sitei269ADPBy similarity1
Binding sitei286ADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi162 – 165ADPBy similarity4
Nucleotide bindingi181 – 185ADPBy similarity5
Nucleotide bindingi262 – 265ADPBy similarity4

GO - Molecular functioni

  • ADP receptor activity Source: MGI
  • G-protein coupled adenosine receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-417957 P2Y receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 12
Short name:
P2Y12
Gene namesi
Name:P2ry12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1918089 P2ry12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 56Helical; Name=1By similarityAdd BLAST23
Topological domaini57 – 67CytoplasmicBy similarityAdd BLAST11
Transmembranei68 – 88Helical; Name=2By similarityAdd BLAST21
Topological domaini89 – 103ExtracellularBy similarityAdd BLAST15
Transmembranei104 – 124Helical; Name=3By similarityAdd BLAST21
Topological domaini125 – 148CytoplasmicBy similarityAdd BLAST24
Transmembranei149 – 168Helical; Name=4By similarityAdd BLAST20
Topological domaini169 – 191ExtracellularBy similarityAdd BLAST23
Transmembranei192 – 213Helical; Name=5By similarityAdd BLAST22
Topological domaini214 – 239CytoplasmicBy similarityAdd BLAST26
Transmembranei240 – 265Helical; Name=6By similarityAdd BLAST26
Topological domaini266 – 284ExtracellularBy similarityAdd BLAST19
Transmembranei285 – 304Helical; Name=7By similarityAdd BLAST20
Topological domaini305 – 347CytoplasmicBy similarityAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile, but display impaired blood coagulation, due to defects in platelet aggregation and thrombus formation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700381 – 347P2Y purinoceptor 12Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi23 ↔ 276PROSITE-ProRule annotation
Modified residuei61PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Disulfide bondi103 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9CPV9
PaxDbiQ9CPV9
PRIDEiQ9CPV9

PTM databases

iPTMnetiQ9CPV9
PhosphoSitePlusiQ9CPV9
SwissPalmiQ9CPV9

Expressioni

Gene expression databases

BgeeiENSMUSG00000036353
CleanExiMM_P2RY12
ExpressionAtlasiQ9CPV9 baseline and differential
GenevisibleiQ9CPV9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051353

Structurei

3D structure databases

ProteinModelPortaliQ9CPV9
SMRiQ9CPV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The transmembrane domain is composed of seven transmembrane helices; most of these are not strictly perpendicular to the plane of the membrane, but are tilted and/or kinked. Agonist binding promotes a conformation change in the extracellular loops that leads to an inward movement of the transmembrane helices. Antagonists can bind to an overlapping site, but block the inward movement of the transmembrane helices (By similarity).By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFYD Eukaryota
ENOG410ZJD1 LUCA
GeneTreeiENSGT00640000091213
HOGENOMiHOG000273884
HOVERGENiHBG108228
InParanoidiQ9CPV9
KOiK04298
OMAiIKVFIII
OrthoDBiEOG091G0B3H
PhylomeDBiQ9CPV9
TreeFamiTF330969

Family and domain databases

CDDicd15150 7tmA_P2Y12, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005394 P2Y12_rcpt
PANTHERiPTHR24233:SF0 PTHR24233:SF0, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01569 P2Y12PRNCPTR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CPV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVPGVNTTS ANTTFSPGTS TLCVRDYKIT QVLFPLLYTV LFFAGLITNS
60 70 80 90 100
LAMRIFFQIR SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGPLRT
110 120 130 140 150
LVCQVTSVTF YFTMYISISF LGLITIDRYL KTTRPFKTSS PSNLLGAKIL
160 170 180 190 200
SVVIWAFMFL ISLPNMILTN RRPKDKDVTK CSFLKSEFGL VWHEIVNYIC
210 220 230 240 250
QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKVPKKKV NVKVFIIIAV
260 270 280 290 300
FFICFVPFHF ARIPYTLSQT RAVFDCSAEN TLFYVKESTL WLTSLNACLD
310 320 330 340
PFIYFFLCKS FRNSLTSMLR CSNSTSTSGT NKKKGQEGGE PSEETPM
Length:347
Mass (Da):39,474
Last modified:June 1, 2001 - v1
Checksum:iF107488E57E025F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013804 mRNA Translation: BAB29000.1
AK014807 mRNA Translation: BAB29561.1
BC027381 mRNA Translation: AAH27381.1
CCDSiCCDS17373.1
RefSeqiNP_081847.3, NM_027571.3
XP_006502146.1, XM_006502083.3
XP_006502147.1, XM_006502084.3
XP_006502148.1, XM_006502085.3
UniGeneiMm.422675

Genome annotation databases

EnsembliENSMUST00000050360; ENSMUSP00000051353; ENSMUSG00000036353
ENSMUST00000170388; ENSMUSP00000126819; ENSMUSG00000036353
ENSMUST00000196583; ENSMUSP00000143036; ENSMUSG00000036353
ENSMUST00000199609; ENSMUSP00000143521; ENSMUSG00000036353
GeneIDi70839
KEGGimmu:70839
UCSCiuc008pir.2 mouse

Similar proteinsi

Entry informationi

Entry nameiP2Y12_MOUSE
AccessioniPrimary (citable) accession number: Q9CPV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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