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Protein

F-box only protein 32

Gene

Fbxo32

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 32
Alternative name(s):
Atrogin-1
Muscle atrophy F-box protein
Short name:
MAFbx
Gene namesi
Name:Fbxo32
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914981 Fbxo32

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199231 – 355F-box only protein 32Add BLAST355

Proteomic databases

PaxDbiQ9CPU7
PeptideAtlasiQ9CPU7
PRIDEiQ9CPU7

PTM databases

PhosphoSitePlusiQ9CPU7

Expressioni

Tissue specificityi

Specifically expressed in cardiac and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000022358 Expressed in 235 organ(s), highest expression level in gastrocnemius
CleanExiMM_FBXO32
GenevisibleiQ9CPU7 MM

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.By similarity

Protein-protein interaction databases

BioGridi212401, 156 interactors
CORUMiQ9CPU7
IntActiQ9CPU7, 2 interactors
MINTiQ9CPU7
STRINGi10090.ENSMUSP00000022986

Structurei

3D structure databases

ProteinModelPortaliQ9CPU7
SMRiQ9CPU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 271F-boxAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi62 – 67Nuclear localization signalBy similarity6
Motifi169 – 173Nuclear export signalBy similarity5
Motifi280 – 295Bipartite nuclear localization signalBy similarityAdd BLAST16

Phylogenomic databases

eggNOGiKOG3926 Eukaryota
ENOG410YPWK LUCA
GeneTreeiENSGT00390000004915
HOGENOMiHOG000263478
HOVERGENiHBG051572
InParanoidiQ9CPU7
KOiK10305
OMAiCRHCHIL
OrthoDBiEOG091G0M92
PhylomeDBiQ9CPU7
TreeFamiTF313070

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
SUPFAMiSSF81383 SSF81383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CPU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFLGQDWRS PGQSWVKTAD GWKRFLDEKS GSFVSDLSSY CNKEVYSKEN
60 70 80 90 100
LFSSLNYDVA AKKRKKDIQN SKTKTQYFHQ EKWIYVHKGS TKERHGYCTL
110 120 130 140 150
GEAFNRLDFS TAILDSRRFN YVVRLLELIA KSQLTSLSGI AQKNFMNILE
160 170 180 190 200
KVVLKVLEDQ QNIRLIRELL QTLYTSLCTL VQRVGKSVLV GNINMWVYRM
210 220 230 240 250
ETILHWQQQL NSIQISRPAF KGLTITDLPV CLQLNIMQRL SDGRDLVSLG
260 270 280 290 300
QAAPDLHVLS EDRLLWKRLC QYHFSERQIR KRLILSDKGQ LDWKKMYFKL
310 320 330 340 350
VRCYPRREQY GVTLQLCKHC HILSWKGTDH PCTANNPESC SVSLSPQDFI

NLFKF
Length:355
Mass (Da):41,504
Last modified:June 1, 2001 - v1
Checksum:iF464997EB97909A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441120 mRNA Translation: AAL49563.1
AK014793 mRNA Translation: BAB29555.1
AK014612 mRNA Translation: BAB29463.1
BC027211 mRNA Translation: AAH27211.1
CCDSiCCDS27491.1
RefSeqiNP_080622.1, NM_026346.3
UniGeneiMm.25683

Genome annotation databases

EnsembliENSMUST00000022986; ENSMUSP00000022986; ENSMUSG00000022358
ENSMUST00000230488; ENSMUSP00000155258; ENSMUSG00000116076
GeneIDi67731
KEGGimmu:67731
UCSCiuc007vtk.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441120 mRNA Translation: AAL49563.1
AK014793 mRNA Translation: BAB29555.1
AK014612 mRNA Translation: BAB29463.1
BC027211 mRNA Translation: AAH27211.1
CCDSiCCDS27491.1
RefSeqiNP_080622.1, NM_026346.3
UniGeneiMm.25683

3D structure databases

ProteinModelPortaliQ9CPU7
SMRiQ9CPU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212401, 156 interactors
CORUMiQ9CPU7
IntActiQ9CPU7, 2 interactors
MINTiQ9CPU7
STRINGi10090.ENSMUSP00000022986

PTM databases

PhosphoSitePlusiQ9CPU7

Proteomic databases

PaxDbiQ9CPU7
PeptideAtlasiQ9CPU7
PRIDEiQ9CPU7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022986; ENSMUSP00000022986; ENSMUSG00000022358
ENSMUST00000230488; ENSMUSP00000155258; ENSMUSG00000116076
GeneIDi67731
KEGGimmu:67731
UCSCiuc007vtk.3 mouse

Organism-specific databases

CTDi114907
MGIiMGI:1914981 Fbxo32

Phylogenomic databases

eggNOGiKOG3926 Eukaryota
ENOG410YPWK LUCA
GeneTreeiENSGT00390000004915
HOGENOMiHOG000263478
HOVERGENiHBG051572
InParanoidiQ9CPU7
KOiK10305
OMAiCRHCHIL
OrthoDBiEOG091G0M92
PhylomeDBiQ9CPU7
TreeFamiTF313070

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q9CPU7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022358 Expressed in 235 organ(s), highest expression level in gastrocnemius
CleanExiMM_FBXO32
GenevisibleiQ9CPU7 MM

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
SUPFAMiSSF81383 SSF81383, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX32_MOUSE
AccessioniPrimary (citable) accession number: Q9CPU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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