UniProtKB - Q9CPU4 (MGST3_MOUSE)
Protein
Microsomal glutathione S-transferase 3
Gene
Mgst3
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes oxydation of hydroxy-fatty acids. May participate to the lipid metabolism.By similarity
Catalytic activityi
Activity regulationi
Inhibited by MK-886 and leukotriene C4.By similarity
GO - Molecular functioni
- glutathione peroxidase activity Source: MGI
- glutathione transferase activity Source: GO_Central
- identical protein binding Source: MGI
- leukotriene-C4 synthase activity Source: MGI
GO - Biological processi
- leukotriene biosynthetic process Source: MGI
- lipid metabolic process Source: MGI
- response to organonitrogen compound Source: Ensembl
Keywordsi
Molecular function | Oxidoreductase, Transferase |
Enzyme and pathway databases
Reactomei | R-MMU-156590, Glutathione conjugation R-MMU-5423646, Aflatoxin activation and detoxification |
Names & Taxonomyi
Protein namesi | Recommended name: Microsomal glutathione S-transferase 3CuratedShort name: Microsomal GST-3 Alternative name(s): Glutathione peroxidase MGST3By similarity (EC:1.11.1.-) Microsomal glutathione S-transferase IIIBy similarity Short name: Microsomal GST-IIIBy similarity |
Gene namesi | Name:Mgst3Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913697, Mgst3 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
- Microsome membrane By similarity; Multi-pass membrane protein By similarity
- Microsome membrane By similarity; Lipid-anchor By similarity
Other locations
- Membrane By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nuclear envelope Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: MGI
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 9 – 29 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 71 – 91 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 120 – 140 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000217742 | 1 – 153 | Microsomal glutathione S-transferase 3Add BLAST | 153 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 151 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
EPDi | Q9CPU4 |
jPOSTi | Q9CPU4 |
MaxQBi | Q9CPU4 |
PaxDbi | Q9CPU4 |
PeptideAtlasi | Q9CPU4 |
PRIDEi | Q9CPU4 |
PTM databases
iPTMneti | Q9CPU4 |
PhosphoSitePlusi | Q9CPU4 |
SwissPalmi | Q9CPU4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000026688, Expressed in stomach and 328 other tissues |
Genevisiblei | Q9CPU4, MM |
Interactioni
GO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 211481, 3 interactors |
IntActi | Q9CPU4, 4 interactors |
STRINGi | 10090.ENSMUSP00000028005 |
Miscellaneous databases
RNActi | Q9CPU4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the MAPEG family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S4E5, Eukaryota |
GeneTreei | ENSGT00390000008608 |
HOGENOMi | CLU_110291_1_0_1 |
InParanoidi | Q9CPU4 |
OMAi | QTMLFTL |
OrthoDBi | 1609516at2759 |
PhylomeDBi | Q9CPU4 |
TreeFami | TF105328 |
Family and domain databases
Gene3Di | 1.20.120.550, 1 hit |
InterProi | View protein in InterPro IPR023352, MAPEG-like_dom_sf IPR001129, Membr-assoc_MAPEG |
Pfami | View protein in Pfam PF01124, MAPEG, 1 hit |
SUPFAMi | SSF161084, SSF161084, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9CPU4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVLSKEYGF VLLTGAASFV MVLHLAINVG KARKKYKVEY PVMYSTDPEN
60 70 80 90 100
GHMFNCIQRA HQNTLEVYPP FLFFLTVGGV YHPRIASGLG LAWIIGRVLY
110 120 130 140 150
AYGYYTGDPS KRYRGAVGSL ALFALMGTTV CSAFQHLGWI RPGLGYGSRS
CHH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 142 | P → R in BAB25726 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK003246 mRNA Translation: BAB22665.1 AK003309 mRNA Translation: BAB22706.1 AK003476 mRNA Translation: BAB22808.1 AK003492 mRNA Translation: BAB22819.1 AK008533 mRNA Translation: BAB25726.1 AK135742 mRNA Translation: BAE22638.1 BC029669 mRNA Translation: AAH29669.1 |
CCDSi | CCDS15457.1 |
RefSeqi | NP_079845.1, NM_025569.1 |
Genome annotation databases
Ensembli | ENSMUST00000028005; ENSMUSP00000028005; ENSMUSG00000026688 |
GeneIDi | 66447 |
KEGGi | mmu:66447 |
UCSCi | uc007dky.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK003246 mRNA Translation: BAB22665.1 AK003309 mRNA Translation: BAB22706.1 AK003476 mRNA Translation: BAB22808.1 AK003492 mRNA Translation: BAB22819.1 AK008533 mRNA Translation: BAB25726.1 AK135742 mRNA Translation: BAE22638.1 BC029669 mRNA Translation: AAH29669.1 |
CCDSi | CCDS15457.1 |
RefSeqi | NP_079845.1, NM_025569.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 211481, 3 interactors |
IntActi | Q9CPU4, 4 interactors |
STRINGi | 10090.ENSMUSP00000028005 |
PTM databases
iPTMneti | Q9CPU4 |
PhosphoSitePlusi | Q9CPU4 |
SwissPalmi | Q9CPU4 |
Proteomic databases
EPDi | Q9CPU4 |
jPOSTi | Q9CPU4 |
MaxQBi | Q9CPU4 |
PaxDbi | Q9CPU4 |
PeptideAtlasi | Q9CPU4 |
PRIDEi | Q9CPU4 |
Protocols and materials databases
Antibodypediai | 34331, 116 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000028005; ENSMUSP00000028005; ENSMUSG00000026688 |
GeneIDi | 66447 |
KEGGi | mmu:66447 |
UCSCi | uc007dky.1, mouse |
Organism-specific databases
CTDi | 4259 |
MGIi | MGI:1913697, Mgst3 |
Phylogenomic databases
eggNOGi | ENOG502S4E5, Eukaryota |
GeneTreei | ENSGT00390000008608 |
HOGENOMi | CLU_110291_1_0_1 |
InParanoidi | Q9CPU4 |
OMAi | QTMLFTL |
OrthoDBi | 1609516at2759 |
PhylomeDBi | Q9CPU4 |
TreeFami | TF105328 |
Enzyme and pathway databases
Reactomei | R-MMU-156590, Glutathione conjugation R-MMU-5423646, Aflatoxin activation and detoxification |
Miscellaneous databases
BioGRID-ORCSi | 66447, 0 hits in 17 CRISPR screens |
ChiTaRSi | Mgst3, mouse |
PROi | PR:Q9CPU4 |
RNActi | Q9CPU4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026688, Expressed in stomach and 328 other tissues |
Genevisiblei | Q9CPU4, MM |
Family and domain databases
Gene3Di | 1.20.120.550, 1 hit |
InterProi | View protein in InterPro IPR023352, MAPEG-like_dom_sf IPR001129, Membr-assoc_MAPEG |
Pfami | View protein in Pfam PF01124, MAPEG, 1 hit |
SUPFAMi | SSF161084, SSF161084, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MGST3_MOUSE | |
Accessioni | Q9CPU4Primary (citable) accession number: Q9CPU4 Secondary accession number(s): Q3UXC5, Q9D834 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families