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Protein

Apoptosis facilitator Bcl-2-like protein 14

Gene

Bcl2l14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in apoptosis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis facilitator Bcl-2-like protein 14
Short name:
Bcl2-L-14
Gene namesi
Name:Bcl2l14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914063 Bcl2l14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430761 – 328Apoptosis facilitator Bcl-2-like protein 14Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CPT0
PaxDbiQ9CPT0
PeptideAtlasiQ9CPT0
PRIDEiQ9CPT0

PTM databases

iPTMnetiQ9CPT0
PhosphoSitePlusiQ9CPT0

Expressioni

Gene expression databases

BgeeiENSMUSG00000030200 Expressed in 118 organ(s), highest expression level in testis
CleanExiMM_BCL2L14
ExpressionAtlasiQ9CPT0 baseline and differential
GenevisibleiQ9CPT0 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FauP355454EBI-8296066,EBI-309546

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211735, 1 interactor
IntActiQ9CPT0, 1 interactor
MINTiQ9CPT0
STRINGi10090.ENSMUSP00000032321

Structurei

3D structure databases

ProteinModelPortaliQ9CPT0
SMRiQ9CPT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi213 – 227BH3Add BLAST15
Motifi309 – 316BH28

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00390000007293
HOGENOMiHOG000013215
HOVERGENiHBG050649
InParanoidiQ9CPT0
OMAiNFSPWVQ
OrthoDBiEOG091G0BS5
PhylomeDBiQ9CPT0
TreeFamiTF336214

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR033229 BCL2L14
IPR036834 Blc2-like_sf
PANTHERiPTHR14965:SF1 PTHR14965:SF1, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CPT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCSTSVYDLE DIPLEDDDPN SIEFKILAFY ARHHVFKNTP AVFSPKLSRT
60 70 80 90 100
RSLSQKALGT WSTDSWTQVS LPCRGSPSSE KNISLGKKKS SWRTLFRVAE
110 120 130 140 150
KEEGLPSSPK EIRAQGPQGP FPVERQSGFH NQHWPRSLSS VEQRLESEVV
160 170 180 190 200
DSKVACIANR VAEIVYSWPP PDVIHSQGGS KLKERVSEIL YFRFEGPCDS
210 220 230 240 250
KNKDGEDQII SKIVELLKFS GDQLGREIKK DKALMSSFQD GLSYSTFKTI
260 270 280 290 300
TDLFLRDVDT RGESEVKARG FKAALAIDAI AKLTAIDNHP MNRMLGFGTK
310 320
YLREYFSPWV QQNGGWEKIL GISHEEVD
Length:328
Mass (Da):36,992
Last modified:June 1, 2001 - v1
Checksum:iFAC47379F008314C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZF2D3YZF2_MOUSE
Apoptosis facilitator Bcl-2-like pr...
Bcl2l14
126Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105L → P in AAH25541 (PubMed:15489334).Curated1
Sequence conflicti156C → F in BAB30545 (PubMed:16141072).Curated1
Sequence conflicti202Missing in AAH25541 (PubMed:15489334).Curated1
Sequence conflicti269R → Q in AAH25541 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008682 mRNA Translation: BAB25830.1
AK016670 mRNA Translation: BAB30370.1
AK016997 mRNA Translation: BAB30545.1
AK018579 mRNA Translation: BAB31290.1
AK160247 mRNA Translation: BAE35712.1
BC025541 mRNA Translation: AAH25541.1
CCDSiCCDS20636.1
RefSeqiNP_080054.1, NM_025778.3
XP_006506547.1, XM_006506484.3
UniGeneiMm.474472

Genome annotation databases

EnsembliENSMUST00000032321; ENSMUSP00000032321; ENSMUSG00000030200
ENSMUST00000111960; ENSMUSP00000107591; ENSMUSG00000030200
ENSMUST00000163589; ENSMUSP00000132525; ENSMUSG00000030200
GeneIDi66813
KEGGimmu:66813
UCSCiuc009ekh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008682 mRNA Translation: BAB25830.1
AK016670 mRNA Translation: BAB30370.1
AK016997 mRNA Translation: BAB30545.1
AK018579 mRNA Translation: BAB31290.1
AK160247 mRNA Translation: BAE35712.1
BC025541 mRNA Translation: AAH25541.1
CCDSiCCDS20636.1
RefSeqiNP_080054.1, NM_025778.3
XP_006506547.1, XM_006506484.3
UniGeneiMm.474472

3D structure databases

ProteinModelPortaliQ9CPT0
SMRiQ9CPT0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211735, 1 interactor
IntActiQ9CPT0, 1 interactor
MINTiQ9CPT0
STRINGi10090.ENSMUSP00000032321

PTM databases

iPTMnetiQ9CPT0
PhosphoSitePlusiQ9CPT0

Proteomic databases

MaxQBiQ9CPT0
PaxDbiQ9CPT0
PeptideAtlasiQ9CPT0
PRIDEiQ9CPT0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032321; ENSMUSP00000032321; ENSMUSG00000030200
ENSMUST00000111960; ENSMUSP00000107591; ENSMUSG00000030200
ENSMUST00000163589; ENSMUSP00000132525; ENSMUSG00000030200
GeneIDi66813
KEGGimmu:66813
UCSCiuc009ekh.1 mouse

Organism-specific databases

CTDi79370
MGIiMGI:1914063 Bcl2l14

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00390000007293
HOGENOMiHOG000013215
HOVERGENiHBG050649
InParanoidiQ9CPT0
OMAiNFSPWVQ
OrthoDBiEOG091G0BS5
PhylomeDBiQ9CPT0
TreeFamiTF336214

Miscellaneous databases

PROiPR:Q9CPT0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030200 Expressed in 118 organ(s), highest expression level in testis
CleanExiMM_BCL2L14
ExpressionAtlasiQ9CPT0 baseline and differential
GenevisibleiQ9CPT0 MM

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR033229 BCL2L14
IPR036834 Blc2-like_sf
PANTHERiPTHR14965:SF1 PTHR14965:SF1, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2L14_MOUSE
AccessioniPrimary (citable) accession number: Q9CPT0
Secondary accession number(s): Q3TVA7, Q8R141, Q9D3W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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