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Protein

ATP synthase subunit g, mitochondrial

Gene

Atp5mg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit g, mitochondrialCurated
Short name:
ATPase subunit g
Alternative name(s):
ATP synthase membrane subunit gCurated
Gene namesi
Name:Atp5mgBy similarity
Synonyms:Atp5l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1351597 Atp5l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000716922 – 103ATP synthase subunit g, mitochondrialAdd BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei11N6-acetyllysineCombined sources1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei35N6-acetyllysineCombined sources1
Modified residuei54N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CPQ8
MaxQBiQ9CPQ8
PaxDbiQ9CPQ8
PeptideAtlasiQ9CPQ8
PRIDEiQ9CPQ8
TopDownProteomicsiQ9CPQ8

PTM databases

iPTMnetiQ9CPQ8
PhosphoSitePlusiQ9CPQ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000038717 Expressed in 47 organ(s), highest expression level in heart
GenevisibleiQ9CPQ8 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi205227, 2 interactors
IntActiQ9CPQ8, 2 interactors
STRINGi10090.ENSMUSP00000136375

Structurei

3D structure databases

ProteinModelPortaliQ9CPQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase g subunit family.Curated

Phylogenomic databases

eggNOGiKOG4103 Eukaryota
ENOG4111TZ1 LUCA
GeneTreeiENSGT00390000009724
HOGENOMiHOG000007506
HOVERGENiHBG050614
InParanoidiQ9CPQ8
KOiK02140
OMAiWQYAKVE
OrthoDBiEOG091G16ZZ
PhylomeDBiQ9CPQ8
TreeFamiTF313978

Family and domain databases

InterProiView protein in InterPro
IPR006808 ATP_synth_F0_gsu_mt
IPR016702 ATP_synth_su_G_mt_met
PANTHERiPTHR12386 PTHR12386, 1 hit
PfamiView protein in Pfam
PF04718 ATP-synt_G, 1 hit
PIRSFiPIRSF017835 ATP-synth_g_mitoch_animal, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKFIRNFAE KAPSMVAAAV TYSKPRLATF WHYAKVELVP PTPAEIPTAI
60 70 80 90 100
QSVKKIIQSA KTGSFKHLTV KEAVLNGLVA TEVWMWFYIG EIIGKRGIVG

YDV
Length:103
Mass (Da):11,425
Last modified:June 1, 2001 - v1
Checksum:i66BB25CECD67AA33
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56I → M in CAA76699 (PubMed:10361692).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17223 mRNA Translation: CAA76699.1
AK005175 mRNA Translation: BAB23862.1
AK005321 mRNA Translation: BAB23952.1
AK005380 mRNA Translation: BAB23987.1
AK008002 mRNA Translation: BAB25401.1
AK008012 mRNA Translation: BAB25408.1
AK008030 mRNA Translation: BAB25420.1
AK008087 mRNA Translation: BAB25451.1
AK008183 mRNA Translation: BAB25516.1
AK008251 mRNA Translation: BAB25558.1
AK008321 mRNA Translation: BAB25600.1
AK009465 mRNA Translation: BAB26305.1
AK009468 mRNA Translation: BAB26308.1
AK009471 mRNA Translation: BAB26310.1
AK009612 mRNA Translation: BAB26392.1
AK009806 mRNA Translation: BAB26514.1
AK011038 mRNA Translation: BAB27351.1
AK011046 mRNA Translation: BAB27357.1
AK011099 mRNA Translation: BAB27396.1
AK019252 mRNA Translation: BAB31628.1
AK019274 mRNA Translation: BAB31641.1
AK019320 mRNA Translation: BAB31664.1
AK019343 mRNA Translation: BAB31670.1
AK019350 mRNA Translation: BAB31672.1
AK019355 mRNA Translation: BAB31676.1
BC031384 mRNA Translation: AAH31384.1
BC086880 mRNA Translation: AAH86880.1
BC089555 mRNA Translation: AAH89555.1
BC094407 mRNA Translation: AAH94407.1
CCDSiCCDS40604.1
RefSeqiNP_038823.2, NM_013795.5
UniGeneiMm.14663
Mm.485732

Genome annotation databases

EnsembliENSMUST00000043675; ENSMUSP00000047960; ENSMUSG00000038717
GeneIDi27425
KEGGimmu:27425
UCSCiuc009per.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17223 mRNA Translation: CAA76699.1
AK005175 mRNA Translation: BAB23862.1
AK005321 mRNA Translation: BAB23952.1
AK005380 mRNA Translation: BAB23987.1
AK008002 mRNA Translation: BAB25401.1
AK008012 mRNA Translation: BAB25408.1
AK008030 mRNA Translation: BAB25420.1
AK008087 mRNA Translation: BAB25451.1
AK008183 mRNA Translation: BAB25516.1
AK008251 mRNA Translation: BAB25558.1
AK008321 mRNA Translation: BAB25600.1
AK009465 mRNA Translation: BAB26305.1
AK009468 mRNA Translation: BAB26308.1
AK009471 mRNA Translation: BAB26310.1
AK009612 mRNA Translation: BAB26392.1
AK009806 mRNA Translation: BAB26514.1
AK011038 mRNA Translation: BAB27351.1
AK011046 mRNA Translation: BAB27357.1
AK011099 mRNA Translation: BAB27396.1
AK019252 mRNA Translation: BAB31628.1
AK019274 mRNA Translation: BAB31641.1
AK019320 mRNA Translation: BAB31664.1
AK019343 mRNA Translation: BAB31670.1
AK019350 mRNA Translation: BAB31672.1
AK019355 mRNA Translation: BAB31676.1
BC031384 mRNA Translation: AAH31384.1
BC086880 mRNA Translation: AAH86880.1
BC089555 mRNA Translation: AAH89555.1
BC094407 mRNA Translation: AAH94407.1
CCDSiCCDS40604.1
RefSeqiNP_038823.2, NM_013795.5
UniGeneiMm.14663
Mm.485732

3D structure databases

ProteinModelPortaliQ9CPQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205227, 2 interactors
IntActiQ9CPQ8, 2 interactors
STRINGi10090.ENSMUSP00000136375

PTM databases

iPTMnetiQ9CPQ8
PhosphoSitePlusiQ9CPQ8

Proteomic databases

EPDiQ9CPQ8
MaxQBiQ9CPQ8
PaxDbiQ9CPQ8
PeptideAtlasiQ9CPQ8
PRIDEiQ9CPQ8
TopDownProteomicsiQ9CPQ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043675; ENSMUSP00000047960; ENSMUSG00000038717
GeneIDi27425
KEGGimmu:27425
UCSCiuc009per.2 mouse

Organism-specific databases

CTDi27425
MGIiMGI:1351597 Atp5l

Phylogenomic databases

eggNOGiKOG4103 Eukaryota
ENOG4111TZ1 LUCA
GeneTreeiENSGT00390000009724
HOGENOMiHOG000007506
HOVERGENiHBG050614
InParanoidiQ9CPQ8
KOiK02140
OMAiWQYAKVE
OrthoDBiEOG091G16ZZ
PhylomeDBiQ9CPQ8
TreeFamiTF313978

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Miscellaneous databases

PROiPR:Q9CPQ8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038717 Expressed in 47 organ(s), highest expression level in heart
GenevisibleiQ9CPQ8 MM

Family and domain databases

InterProiView protein in InterPro
IPR006808 ATP_synth_F0_gsu_mt
IPR016702 ATP_synth_su_G_mt_met
PANTHERiPTHR12386 PTHR12386, 1 hit
PfamiView protein in Pfam
PF04718 ATP-synt_G, 1 hit
PIRSFiPIRSF017835 ATP-synth_g_mitoch_animal, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATP5L_MOUSE
AccessioniPrimary (citable) accession number: Q9CPQ8
Secondary accession number(s): O70590, Q5M9M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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