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Protein

Mitochondrial import receptor subunit TOM22 homolog

Gene

Tomm22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5205685 Pink/Parkin Mediated Mitophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM22 homolog
Alternative name(s):
Translocase of outer membrane 22 kDa subunit homolog
Gene namesi
Name:Tomm22
Synonyms:Tom22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2450248 Tomm22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 83CytoplasmicSequence analysisAdd BLAST82
Transmembranei84 – 103HelicalSequence analysisAdd BLAST20
Topological domaini104 – 142Mitochondrial intermembraneSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000761082 – 142Mitochondrial import receptor subunit TOM22 homologAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei43PhosphothreonineBy similarity1
Modified residuei45PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CPQ3
MaxQBiQ9CPQ3
PaxDbiQ9CPQ3
PeptideAtlasiQ9CPQ3
PRIDEiQ9CPQ3
TopDownProteomicsiQ9CPQ3

PTM databases

iPTMnetiQ9CPQ3
PhosphoSitePlusiQ9CPQ3

Expressioni

Gene expression databases

BgeeiENSMUSG00000022427
GenevisibleiQ9CPQ3 MM

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with PPP2R2B and TOMM40 (By similarity).By similarity

Protein-protein interaction databases

BioGridi230178, 3 interactors
IntActiQ9CPQ3, 2 interactors
MINTiQ9CPQ3
STRINGi10090.ENSMUSP00000023062

Structurei

3D structure databases

ProteinModelPortaliQ9CPQ3
SMRiQ9CPQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 50Import sequence; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarity10
Regioni83 – 103TMD; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd BLAST21
Regioni123 – 142C-tail signal; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 38Poly-Asp4
Compositional biasi110 – 118Poly-Gln9

Domaini

The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins. Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity).By similarity

Sequence similaritiesi

Belongs to the Tom22 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4111 Eukaryota
ENOG41122K3 LUCA
GeneTreeiENSGT00390000016475
HOGENOMiHOG000067816
HOVERGENiHBG061819
InParanoidiQ9CPQ3
KOiK17769
OMAiMFPEPLR
OrthoDBiEOG091G0XN1
PhylomeDBiQ9CPQ3
TreeFamiTF106201

Family and domain databases

InterProiView protein in InterPro
IPR005683 Tom22
PANTHERiPTHR12504:SF0 PTHR12504:SF0, 1 hit
PfamiView protein in Pfam
PF04281 Tom22, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVAAAGA GEPLSPEELL PKAEAEKAEE ELEEDDDDEL DETLSERLWG
60 70 80 90 100
LTEMFPERVR SAAGATFDLS LFVAQKMYRF SRAALWIGTT SFMILVLPVV
110 120 130 140
FETEKLQMEQ QQQLQQRQIL LGPNTGLSGG MPGALPPLPG KM
Length:142
Mass (Da):15,537
Last modified:January 23, 2007 - v3
Checksum:iA5182A39B6EBBFDA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38D → H in BAB25482 (PubMed:16141072).Curated1
Sequence conflicti65A → T in BAB25482 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008133 mRNA Translation: BAB25482.1
AK009868 mRNA Translation: BAB26553.1
AK013471 mRNA Translation: BAB28871.1
AK049442 mRNA Translation: BAC33752.1
AK150360 mRNA Translation: BAE29495.1
AK152843 mRNA Translation: BAE31536.1
AK167803 mRNA Translation: BAE39830.1
BC056920 mRNA Translation: AAH56920.1
CCDSiCCDS27646.1
RefSeqiNP_766197.2, NM_172609.3
UniGeneiMm.246435
Mm.485795

Genome annotation databases

EnsembliENSMUST00000023062; ENSMUSP00000023062; ENSMUSG00000022427
GeneIDi223696
KEGGimmu:223696
UCSCiuc007wud.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTOM22_MOUSE
AccessioniPrimary (citable) accession number: Q9CPQ3
Secondary accession number(s): Q543M4, Q9D8D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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