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Protein

Cytochrome c oxidase subunit 6C

Gene

Cox6c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cox6c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:104614 Cox6c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini4 – 14Mitochondrial matrixBy similarityAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 55HelicalBy similarityAdd BLAST41
Topological domaini56 – 76Mitochondrial intermembraneBy similarityAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001913021 – 76Cytochrome c oxidase subunit 6CAdd BLAST76

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation of Lys-61 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9CPQ1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9CPQ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CPQ1

PeptideAtlas

More...
PeptideAtlasi
Q9CPQ1

PRoteomics IDEntifications database

More...
PRIDEi
Q9CPQ1

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9CPQ1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9CPQ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9CPQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000014313 Expressed in 311 organ(s), highest expression level in diaphragm

CleanEx database of gene expression profiles

More...
CleanExi
MM_COX6C

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9CPQ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CPQ1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198845, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9CPQ1

Protein interaction database and analysis system

More...
IntActi
Q9CPQ1, 4 interactors

Molecular INTeraction database

More...
MINTi
Q9CPQ1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000014457

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9CPQ1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9CPQ1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J83U Eukaryota
ENOG41124VH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162275

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000039249

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051091

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CPQ1

KEGG Orthology (KO)

More...
KOi
K02268

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARRMKFH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G10KX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CPQ1

TreeFam database of animal gene trees

More...
TreeFami
TF353619

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00927 Cyt_c_Oxidase_VIc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.93.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004204 COX6C
IPR034884 Cytochrome_c_oxidase_VIc/VIIs
IPR037169 Cytochrome_c_oxidase_VIc_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12916 PTHR12916, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02937 COX6C, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD015032 Cyt_c_oxidase_su6c, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81415 SSF81415, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CPQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSGALLPKP QMRGLLAKRL RVHIAGAFIV ALGVAAAYKF GVAEPRKKAY
60 70
AEFYRNYDSM KDFEEMRKAG IFQSAK
Length:76
Mass (Da):8,469
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE02A028CF77D5F4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JDA6A0A0G2JDA6_MOUSE
Cytochrome c oxidase subunit 6C
Cox6c
10Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK012602 mRNA Translation: BAB28348.1
AK013459 mRNA Translation: BAB28866.1
BC024666 mRNA Translation: AAH24666.1
BC094413 mRNA Translation: AAH94413.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27424.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S16083

NCBI Reference Sequences

More...
RefSeqi
NP_444301.1, NM_053071.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.548

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000014457; ENSMUSP00000014457; ENSMUSG00000014313
ENSMUST00000153512; ENSMUSP00000123609; ENSMUSG00000014313
ENSMUST00000156915; ENSMUSP00000122391; ENSMUSG00000014313

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12864

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12864

UCSC genome browser

More...
UCSCi
uc007vmi.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012602 mRNA Translation: BAB28348.1
AK013459 mRNA Translation: BAB28866.1
BC024666 mRNA Translation: AAH24666.1
BC094413 mRNA Translation: AAH94413.1
CCDSiCCDS27424.1
PIRiS16083
RefSeqiNP_444301.1, NM_053071.2
UniGeneiMm.548

3D structure databases

ProteinModelPortaliQ9CPQ1
SMRiQ9CPQ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198845, 2 interactors
CORUMiQ9CPQ1
IntActiQ9CPQ1, 4 interactors
MINTiQ9CPQ1
STRINGi10090.ENSMUSP00000014457

PTM databases

iPTMnetiQ9CPQ1
PhosphoSitePlusiQ9CPQ1

Proteomic databases

EPDiQ9CPQ1
MaxQBiQ9CPQ1
PaxDbiQ9CPQ1
PeptideAtlasiQ9CPQ1
PRIDEiQ9CPQ1
TopDownProteomicsiQ9CPQ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014457; ENSMUSP00000014457; ENSMUSG00000014313
ENSMUST00000153512; ENSMUSP00000123609; ENSMUSG00000014313
ENSMUST00000156915; ENSMUSP00000122391; ENSMUSG00000014313
GeneIDi12864
KEGGimmu:12864
UCSCiuc007vmi.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1345
MGIiMGI:104614 Cox6c

Phylogenomic databases

eggNOGiENOG410J83U Eukaryota
ENOG41124VH LUCA
GeneTreeiENSGT00940000162275
HOGENOMiHOG000039249
HOVERGENiHBG051091
InParanoidiQ9CPQ1
KOiK02268
OMAiARRMKFH
OrthoDBiEOG091G10KX
PhylomeDBiQ9CPQ1
TreeFamiTF353619

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9CPQ1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000014313 Expressed in 311 organ(s), highest expression level in diaphragm
CleanExiMM_COX6C
ExpressionAtlasiQ9CPQ1 baseline and differential
GenevisibleiQ9CPQ1 MM

Family and domain databases

CDDicd00927 Cyt_c_Oxidase_VIc, 1 hit
Gene3Di4.10.93.10, 1 hit
InterProiView protein in InterPro
IPR004204 COX6C
IPR034884 Cytochrome_c_oxidase_VIc/VIIs
IPR037169 Cytochrome_c_oxidase_VIc_sf
PANTHERiPTHR12916 PTHR12916, 1 hit
PfamiView protein in Pfam
PF02937 COX6C, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015032 Cyt_c_oxidase_su6c, 1 hit
SUPFAMiSSF81415 SSF81415, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOX6C_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CPQ1
Secondary accession number(s): Q52KC6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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