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Protein

Nucleoplasmin-3

Gene

Npm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a chaperone.

GO - Biological processi

  • rRNA processing Source: MGI
  • rRNA transcription Source: MGI

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoplasmin-3
Gene namesi
Name:Npm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:894653 Npm3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002194902 – 175Nucleoplasmin-3Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei27Omega-N-methylarginineBy similarity1
Modified residuei147PhosphoserineCombined sources1
Modified residuei151PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9CPP0
MaxQBiQ9CPP0
PaxDbiQ9CPP0
PeptideAtlasiQ9CPP0
PRIDEiQ9CPP0

PTM databases

iPTMnetiQ9CPP0
PhosphoSitePlusiQ9CPP0
SwissPalmiQ9CPP0

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000056209 Expressed in 20 organ(s), highest expression level in thymus
CleanExiMM_NPM3
GenevisibleiQ9CPP0 MM

Interactioni

Protein-protein interaction databases

BioGridi201824, 4 interactors
CORUMiQ9CPP0
IntActiQ9CPP0, 1 interactor
MINTiQ9CPP0

Structurei

3D structure databases

ProteinModelPortaliQ9CPP0
SMRiQ9CPP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 10Ala-rich9
Compositional biasi145 – 159Asp/Glu-rich (highly acidic)Add BLAST15

Sequence similaritiesi

Belongs to the nucleoplasmin family.Curated

Phylogenomic databases

eggNOGiENOG410IZ8K Eukaryota
ENOG41120H8 LUCA
GeneTreeiENSGT00440000034554
HOGENOMiHOG000030911
HOVERGENiHBG045601
InParanoidiQ9CPP0
KOiK11278
OMAiKVPFYTF
OrthoDBiEOG091G0MSK
PhylomeDBiQ9CPP0
TreeFamiTF327704

Family and domain databases

InterProiView protein in InterPro
IPR004301 Nucleoplasmin
IPR024057 Nucleoplasmin_core_dom
IPR036824 Nucleoplasmin_core_dom_sf
PANTHERiPTHR22747 PTHR22747, 1 hit
PfamiView protein in Pfam
PF03066 Nucleoplasmin, 1 hit
SUPFAMiSSF69203 SSF69203, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CPP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGAAAALA FLNQESRARA GGVGGLRVPA PVTMDSFFFG CELSGHTRSF
60 70 80 90 100
TFKVEEEDDT EHVLALNMLC LTEGATDECN VVEVVARDHD NQEIAVPVAN
110 120 130 140 150
LRLSCQPMLS VDDFQLQPPV TFRLKSGSGP VRITGRHQIV CINNDLSEEE
160 170
SDDESEEDEI KLCGILPAKK HRGRP
Length:175
Mass (Da):19,023
Last modified:January 23, 2007 - v3
Checksum:i27E9F37CA22838EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64450 mRNA Translation: AAC53205.1
AK011749 mRNA Translation: BAB27818.1
AK146603 mRNA Translation: BAE27297.1
BC048491 mRNA Translation: AAH48491.1
CCDSiCCDS29865.1
RefSeqiNP_032749.1, NM_008723.1
UniGeneiMm.1406

Genome annotation databases

EnsembliENSMUST00000070215; ENSMUSP00000069578; ENSMUSG00000056209
GeneIDi18150
KEGGimmu:18150
UCSCiuc008hrk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64450 mRNA Translation: AAC53205.1
AK011749 mRNA Translation: BAB27818.1
AK146603 mRNA Translation: BAE27297.1
BC048491 mRNA Translation: AAH48491.1
CCDSiCCDS29865.1
RefSeqiNP_032749.1, NM_008723.1
UniGeneiMm.1406

3D structure databases

ProteinModelPortaliQ9CPP0
SMRiQ9CPP0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201824, 4 interactors
CORUMiQ9CPP0
IntActiQ9CPP0, 1 interactor
MINTiQ9CPP0

PTM databases

iPTMnetiQ9CPP0
PhosphoSitePlusiQ9CPP0
SwissPalmiQ9CPP0

Proteomic databases

EPDiQ9CPP0
MaxQBiQ9CPP0
PaxDbiQ9CPP0
PeptideAtlasiQ9CPP0
PRIDEiQ9CPP0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070215; ENSMUSP00000069578; ENSMUSG00000056209
GeneIDi18150
KEGGimmu:18150
UCSCiuc008hrk.1 mouse

Organism-specific databases

CTDi10360
MGIiMGI:894653 Npm3

Phylogenomic databases

eggNOGiENOG410IZ8K Eukaryota
ENOG41120H8 LUCA
GeneTreeiENSGT00440000034554
HOGENOMiHOG000030911
HOVERGENiHBG045601
InParanoidiQ9CPP0
KOiK11278
OMAiKVPFYTF
OrthoDBiEOG091G0MSK
PhylomeDBiQ9CPP0
TreeFamiTF327704

Miscellaneous databases

PROiPR:Q9CPP0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056209 Expressed in 20 organ(s), highest expression level in thymus
CleanExiMM_NPM3
GenevisibleiQ9CPP0 MM

Family and domain databases

InterProiView protein in InterPro
IPR004301 Nucleoplasmin
IPR024057 Nucleoplasmin_core_dom
IPR036824 Nucleoplasmin_core_dom_sf
PANTHERiPTHR22747 PTHR22747, 1 hit
PfamiView protein in Pfam
PF03066 Nucleoplasmin, 1 hit
SUPFAMiSSF69203 SSF69203, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPM3_MOUSE
AccessioniPrimary (citable) accession number: Q9CPP0
Secondary accession number(s): Q3UJ58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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