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Protein

Histidinol-phosphate aminotransferase 1

Gene

hisC1

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase 1 (hisC1), Histidinol-phosphate aminotransferase 2 (hisC2)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciPMUL272843:G1FZ8-1268-MONOMER
UniPathwayi
UPA00031;UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase 1 (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase 1
Gene namesi
Name:hisC1
Synonyms:hisC
Ordered Locus Names:PM1199
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001534101 – 351Histidinol-phosphate aminotransferase 1Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ9CLM3

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272843.PM1199

Structurei

3D structure databases

ProteinModelPortaliQ9CLM3
SMRiQ9CLM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA
HOGENOMiHOG000288512
KOiK00817
OMAiTYGMYKV

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CLM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSISSLSRKN IQALTPYQSA RRLGGKGDIW LNANEYPTSP DFNLTHRTFN
60 70 80 90 100
RYPEPQPQAV IEGYANYVGV TPENVLVSRG GDESIELIIR AFCEAEDSIL
110 120 130 140 150
YCPPTYGMYA VSAETCGIAL KTVPLTADFQ LNLPEIERQL TGVKVVFVCS
160 170 180 190 200
PNNPTGTLVN RTDLLALLEM TRNKAIVVVD EAYIEFCPQA TMVTELKNYP
210 220 230 240 250
HLAIIRTLSK AFALAGLRCG FTLANKDLIE VLQKVIAPYP LPVPVADLAA
260 270 280 290 300
QALQPAGLQA MQQRVQEILQ NRTALEADLR SLPCVENVFQ SDGNYLLVKF
310 320 330 340 350
KDGQKIFKTL WDQGIILRNQ HSALMLENCI RITIGTAEEN RRVIEAIRKI

A
Length:351
Mass (Da):38,981
Last modified:June 1, 2001 - v1
Checksum:i757529C3656BDF5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA Translation: AAK03283.1
RefSeqiWP_010907066.1, NC_002663.1

Genome annotation databases

EnsemblBacteriaiAAK03283; AAK03283; PM1199
KEGGipmu:PM1199
PATRICifig|272843.6.peg.1210

Similar proteinsi

Entry informationi

Entry nameiHIS81_PASMU
AccessioniPrimary (citable) accession number: Q9CLM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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