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Protein

Argininosuccinate lyase

Gene

argH

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciLLAC272623:L0114-MONOMER
UniPathwayi
UPA00068;UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:LL0125
ORF Names:L0114
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001377801 – 459Argininosuccinate lyaseAdd BLAST459

Proteomic databases

PaxDbiQ9CJ76

Interactioni

Protein-protein interaction databases

STRINGi272623.L0114

Structurei

3D structure databases

ProteinModelPortaliQ9CJ76
SMRiQ9CJ76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiKKNPDVF

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CJ76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEKLWGGRF EASLDKQTEE FGASIKFEQR LAPFDLKGSL AHVKMLGETG
60 70 80 90 100
IITTEESKKI AEGLKKVEEK LLNGQIEFKM ENEDIHMNME SYLHQEIGPL
110 120 130 140 150
AGKLHTARSR NDQVVTDMHL YLKSILEAVL EALKVLRETI VKLAVNQIDT
160 170 180 190 200
IMPGYTHLQH AQPISFGQHL MAYYQMLTRD FERFEFNVKH TDMNPLGAAA
210 220 230 240 250
LAGTTFPIDR MLTTKLLGFE KAYDNSMDAV SDRDFILEFL SNASLLMMHL
260 270 280 290 300
SRFCEELLLW SSHEFKFVSL SDTYSTGSSI MPQKKNPDMA ELIRGKTGRV
310 320 330 340 350
YGNLTALLTV MKGLPLAYNK DFQEDKEGMF DSADTIITSL TVMNGMLSTL
360 370 380 390 400
TVNRVNMEKS TEQDFSNATE LADYLATKGL PFRKAHELVG LLVLDCIKKG
410 420 430 440 450
IYLQDVNLQD YQMLSPLINE DVYEVLKSRT AVSRRNSLGG TGFESVKKQI

EEAKKELQI
Length:459
Mass (Da):51,900
Last modified:April 27, 2001 - v1
Checksum:i85D14D00AE622426
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK04223.1
PIRiE86640
RefSeqiNP_266281.1, NC_002662.1
WP_010905136.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK04223; AAK04223; L0114
GeneIDi1113731
KEGGilla:L0114
PATRICifig|272623.7.peg.138

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK04223.1
PIRiE86640
RefSeqiNP_266281.1, NC_002662.1
WP_010905136.1, NC_002662.1

3D structure databases

ProteinModelPortaliQ9CJ76
SMRiQ9CJ76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L0114

Proteomic databases

PaxDbiQ9CJ76

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK04223; AAK04223; L0114
GeneIDi1113731
KEGGilla:L0114
PATRICifig|272623.7.peg.138

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiKKNPDVF

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00114

BioCyciLLAC272623:L0114-MONOMER

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARLY_LACLA
AccessioniPrimary (citable) accession number: Q9CJ76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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