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Protein

ADP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

nnrD

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide = AMP + phosphate + NADH.UniRule annotation
ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide phosphate = AMP + phosphate + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei215NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi185 – 189ADPUniRule annotation5
Nucleotide bindingi205 – 214ADPUniRule annotation10

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:L57608-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.136UniRule annotation)
Alternative name(s):
ADP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
Name:nnrDUniRule annotation
Ordered Locus Names:LL0259
ORF Names:L57608
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161441 – 275ADP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST275

Proteomic databases

PaxDbiQ9CIU7

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272623.L57608

Structurei

3D structure databases

ProteinModelPortaliQ9CIU7
SMRiQ9CIU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 273YjeF C-terminalUniRule annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni151 – 157NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DR1 Bacteria
COG0063 LUCA
HOGENOMiHOG000024582
KOiK17758
OMAiNLMVHPL

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01049 YJEF_C_1, 1 hit
PS01050 YJEF_C_2, 1 hit
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CIU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIELTDEILA KVIKKRKKAS YKGTYGRLLV IGGNRQYGGA AILVTTSAVY
60 70 80 90 100
SGAGLVSVAL AKENHSALQA RLPEAMTLDF DDLIKLREVA KAADVIVIGP
110 120 130 140 150
GLGLERLDLL TEVLNLLTEN QKLVIDGSAL TLFAREHLDL PFPENTVFTP
160 170 180 190 200
HEMELERLSG LKIGQQTKEE VQDFVNQLGA IVVAKSSETR IFAPNRESFI
210 220 230 240 250
LKIGSPAQAT GGMGDTLAGM VGGFLAQFHG ETEEVVAAAT YLHSLIASVL
260 270
ARKTYVVLPS RLIEEIPLFM KKYEC
Length:275
Mass (Da):29,853
Last modified:June 1, 2001 - v1
Checksum:iD5640F3B197C1AB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK04357.1
PIRiC86657
RefSeqiNP_266415.1, NC_002662.1
WP_010905246.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK04357; AAK04357; L57608
GeneIDi1113869
KEGGilla:L57608
PATRICifig|272623.7.peg.284

Similar proteinsi

Entry informationi

Entry nameiNNRD_LACLA
AccessioniPrimary (citable) accession number: Q9CIU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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