Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable N-acetylmuramidase

Gene

acmA

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for cell separation during growth.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell wall biogenesis/degradation, Septation

Enzyme and pathway databases

BioCyciLLAC272623:L68758-MONOMER

Protein family/group databases

CAZyiCBM50 Carbohydrate-Binding Module Family 50
GH73 Glycoside Hydrolase Family 73

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetylmuramidase (EC:3.2.1.17)
Alternative name(s):
Autolysin
Lysozyme
Peptidoglycan hydrolase
Gene namesi
Name:acmA
Ordered Locus Names:LL0272
ORF Names:L68758
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 57Sequence analysisAdd BLAST57
ChainiPRO_000001211258 – 439Probable N-acetylmuramidaseAdd BLAST382

Proteomic databases

PaxDbiQ9CIT4

Interactioni

Protein-protein interaction databases

STRINGi272623.L68758

Structurei

3D structure databases

ProteinModelPortaliQ9CIT4
SMRiQ9CIT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 284LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini321 – 364LysM 2PROSITE-ProRule annotationAdd BLAST44
Domaini395 – 438LysM 3PROSITE-ProRule annotationAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi287 – 291Poly-Ser5
Compositional biasi370 – 374Poly-Ser5

Domaini

The LysM domains are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Belongs to the glycosyl hydrolase 73 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4107X35 Bacteria
COG1388 LUCA
COG1705 LUCA
HOGENOMiHOG000033783
OMAiYSFRDHS

Family and domain databases

CDDicd00118 LysM, 3 hits
Gene3Di3.10.350.10, 3 hits
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR002901 MGlyc_endo_b_GlcNAc-like_dom
PfamiView protein in Pfam
PF01832 Glucosaminidase, 1 hit
PF01476 LysM, 3 hits
SMARTiView protein in SMART
SM00257 LysM, 3 hits
SM00047 LYZ2, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CIT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVSRIKVKN RHLKKKAKKP LAFYKPATKF AGAVLIAGTL TTTHELLLQQ
60 70 80 90 100
TSPMVQAATN STEAFIESIA ASAKPVADSN GLYPSVMIAQ AILESNWGSS
110 120 130 140 150
QLSRAPYYNL FGIQGTYQGK SVVFKTQEYL NGKWVTKDMP FRVYPSFNQS
160 170 180 190 200
FQDNAYVLKT TNFGNGPYYA KAWRANAATY QAATAALTGK YATDPNYGAS
210 220 230 240 250
LNRIISQYNL TRFDGASSAG TSNSGGSTAT NTNNNSNTSS TTYTVKSGDT
260 270 280 290 300
LWGISQKYGI SVAQIQSANN LKSTVIYIGQ KLVLTTSSSS SNTNSSTSSG
310 320 330 340 350
NSAGTTTPTT SVTPAKPASQ TTIKVKSGDT LWGLSVKYKT TIAQLKSWNH
360 370 380 390 400
LNSDTIFIGQ NLIVSQSAGS SSSSTGSSSA STSSTSNSSA ASNTSIHKVV
410 420 430
KGDTLWGLSQ KSGSPIASIK AWNHLSSDTI LIGQYLRIK
Length:439
Mass (Da):46,592
Last modified:June 1, 2001 - v1
Checksum:iAE4551E4D04CB499
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK04370.1
PIRiH86658
RefSeqiNP_266428.1, NC_002662.1
WP_010905256.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK04370; AAK04370; L68758
GeneIDi1113882
KEGGilla:L68758
PATRICifig|272623.7.peg.298

Similar proteinsi

Entry informationi

Entry nameiACMA_LACLA
AccessioniPrimary (citable) accession number: Q9CIT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health