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Protein

L-lactate dehydrogenase 3

Gene

ldh3

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotation

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Activity regulationi

Allosterically activated by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase 1 (ldh1), L-lactate dehydrogenase 2 (ldh2), L-lactate dehydrogenase 3 (ldh3)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei16NAD; via amide nitrogenUniRule annotation1
Binding sitei37NADUniRule annotation1
Binding sitei42NADUniRule annotation1
Binding sitei69NADUniRule annotation1
Binding sitei95SubstrateUniRule annotation1
Binding sitei150NADUniRule annotation1
Binding sitei160Allosteric activatorUniRule annotation1
Binding sitei175Allosteric activatorUniRule annotation1
Active sitei182Proton acceptorUniRule annotation1
Binding sitei236SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi125 – 127NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Oxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciLLAC272623:L142159-MONOMER
UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase 3UniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDH 3UniRule annotation
Alternative name(s):
L-lactate dehydrogenase X1 Publication
Gene namesi
Name:ldh3UniRule annotation
Synonyms:ldhX1 Publication
Ordered Locus Names:LL1128
ORF Names:L142159
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001683531 – 323L-lactate dehydrogenase 3Add BLAST323

Proteomic databases

PaxDbiQ9CGG8

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272623.L142159

Structurei

3D structure databases

ProteinModelPortaliQ9CGG8
SMRiQ9CGG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 130Substrate bindingUniRule annotation4
Regioni155 – 158Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213793
KOiK00016
OMAiSESCHGW

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CGG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKINNKKVVI VGAGAVGSTY AHNLVVDDLA DEIAIINTNK SKASANSLDL
60 70 80 90 100
LHALPYLNAA PKNIYAADYS DVSDADIVVL SANAPSATFG KNPDRLQLLE
110 120 130 140 150
NKVEMIRDIT RKTMDAGFDG IFLVASNPVD VLAQVVAEVS GLPKHRVIGT
160 170 180 190 200
GTLLETSRMR QIVAEKLQIN PKSIHGYVLA EHGKSSFAAW SNVTVGAIPL
210 220 230 240 250
TTWLKKYPNP EFPTFDEIDQ EIREVGLDIF MQKGNTSYGI AASLARLTRA
260 270 280 290 300
IFRNESVILP VSAYLTGEYG QFDLYTGSPA IIDRTGVRAV LELELTQEEQ
310 320
EKFKASTVLL KENFDSIKEK CTL
Length:323
Mass (Da):35,271
Last modified:June 1, 2001 - v1
Checksum:i87CCB4EA290A15DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK05226.1
PIRiH86765
RefSeqiNP_267284.1, NC_002662.1
WP_010905773.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK05226; AAK05226; L142159
GeneIDi1114768
KEGGilla:L142159
PATRICifig|272623.7.peg.1206

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK05226.1
PIRiH86765
RefSeqiNP_267284.1, NC_002662.1
WP_010905773.1, NC_002662.1

3D structure databases

ProteinModelPortaliQ9CGG8
SMRiQ9CGG8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L142159

Proteomic databases

PaxDbiQ9CGG8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK05226; AAK05226; L142159
GeneIDi1114768
KEGGilla:L142159
PATRICifig|272623.7.peg.1206

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213793
KOiK00016
OMAiSESCHGW

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

BioCyciLLAC272623:L142159-MONOMER

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLDH3_LACLA
AccessioniPrimary (citable) accession number: Q9CGG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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