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Protein

Calcium-transporting ATPase 1

Gene

yoaB

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the transport of calcium.1 Publication

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).1 Publication

Activity regulationi

Inhibited by very high concentrations of cyclopiazonic acid (CPA).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi287Calcium; via carbonyl oxygenBy similarity1
Metal bindingi288Calcium; via carbonyl oxygenBy similarity1
Metal bindingi290Calcium; via carbonyl oxygenBy similarity1
Metal bindingi292CalciumBy similarity1
Active sitei3344-aspartylphosphate intermediateBy similarity1
Metal bindingi713CalciumBy similarity1
Metal bindingi717CalciumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:L2866-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase 1 (EC:3.6.3.8)
Alternative name(s):
LLCA1
Gene namesi
Name:yoaB
Ordered Locus Names:LL1366
ORF Names:L2866
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 72HelicalSequence analysisAdd BLAST23
Transmembranei76 – 95HelicalSequence analysisAdd BLAST20
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei681 – 701HelicalSequence analysisAdd BLAST21
Transmembranei704 – 724HelicalSequence analysisAdd BLAST21
Transmembranei753 – 773HelicalSequence analysisAdd BLAST21
Transmembranei779 – 799HelicalSequence analysisAdd BLAST21
Transmembranei816 – 836HelicalSequence analysisAdd BLAST21
Transmembranei845 – 865HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi54T → Q: Increases sensitivity to CPA. CPA-sensitive; when associated with L-59 and P-295. 1 Publication1
Mutagenesisi59M → L: CPA-sensitive; when associated with Q-54 and P-295. 1 Publication1
Mutagenesisi295S → P: Increases sensitivity to CPA. CPA-sensitive; when associated with Q-54 and L-59. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004245261 – 878Calcium-transporting ATPase 1Add BLAST878

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9CFU9
PRIDEiQ9CFU9

Interactioni

Protein-protein interaction databases

STRINGi272623.L2866

Structurei

3D structure databases

ProteinModelPortaliQ9CFU9
SMRiQ9CFU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C52 Bacteria
COG0474 LUCA
HOGENOMiHOG000265621
KOiK01537
OMAiAQGSKMF

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CFU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPYNQSVNE VLEETKSQFE GLSPKEVKNR QAKDGFNELK EKKKTSTWEL
60 70 80 90 100
FIDTLKDPMV IILLLVAFVQ LFLGEFVESL VIFIVLMINS VVAVVQTKRA
110 120 130 140 150
ESSLDALRQM SAPSAKVLRN GEKTSIPARE LVVGDIVSLE AGDFIPADGR
160 170 180 190 200
LIDVQNLRVE EGMLTGESEP VEKFSDVIEG EVALGDRKNM VFSSSLVVYG
210 220 230 240 250
RADFLVTAIA EQTEIGKIAQ MLETAEAKQT PLQQKLEKFG KQLGWVILAL
260 270 280 290 300
CALIFAVQIL RLFTTNQTAD MQKAVLDSFM FAVAVAVAAI PEALSSVVTI
310 320 330 340 350
VLSVGTNKMA KQHAIMRNLP AVETLGSTSV ICTDKTGTLT QNKMTVVDSF
360 370 380 390 400
LPTQGSKELT DLTQADQKLL LNAMVLCNDS SFSQEGQLLG DPTEVALIAY
410 420 430 440 450
SDKIGYPYQD LREKSPRLAE FPFDSERKLM STINDFEGQK TIFVKGGPDV
460 470 480 490 500
LFNRCNQVFL DGKVQEFTPE LKEKFQAQNE AFSQKALRVL AYAYKPVSDN
510 520 530 540 550
KTELTLTDEN DLILIGLSAM IDPPREAVYD SIAEAKKAGI KTIMITGDHK
560 570 580 590 600
TTAQAIAKDI GLMNEGDMAL TGQELDALTE DELRENLEKI SVYARVSPEN
610 620 630 640 650
KIRIVRAWQN EHQVTAMTGD GVNDAPALKQ ANIGIAMGSG TDVAKDASSM
660 670 680 690 700
ILTDDNFVSI VSAVSIGRVV YDNIKKSISY LFSGNLGAII AIVFALVVGW
710 720 730 740 750
VNPFTALQLL FINLVNDSVP AIALGMEKAE PDVMEKAPRQ LNEGIFANGL
760 770 780 790 800
MRVILIRGSL IGIAAIISQY VGQKTSPEMG VAMAFTTLIL ARTLQTFAAR
810 820 830 840 850
SNSQNILKLG FTTNKYVLMA VTFCLALYSL TTLPFLREIF SIPAAFGWSQ
860 870
WIVAAGLAVI AVICMEILKS IKGVFEKH
Length:878
Mass (Da):96,033
Last modified:June 1, 2001 - v1
Checksum:i0D322BB263E3DF36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK05464.1
PIRiF86795
RefSeqiNP_267522.1, NC_002662.1
WP_010905909.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK05464; AAK05464; L2866
GeneIDi1115016
KEGGilla:L2866
PATRICifig|272623.7.peg.1472

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK05464.1
PIRiF86795
RefSeqiNP_267522.1, NC_002662.1
WP_010905909.1, NC_002662.1

3D structure databases

ProteinModelPortaliQ9CFU9
SMRiQ9CFU9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L2866

Proteomic databases

PaxDbiQ9CFU9
PRIDEiQ9CFU9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK05464; AAK05464; L2866
GeneIDi1115016
KEGGilla:L2866
PATRICifig|272623.7.peg.1472

Phylogenomic databases

eggNOGiENOG4105C52 Bacteria
COG0474 LUCA
HOGENOMiHOG000265621
KOiK01537
OMAiAQGSKMF

Enzyme and pathway databases

BioCyciLLAC272623:L2866-MONOMER

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLLCA1_LACLA
AccessioniPrimary (citable) accession number: Q9CFU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2013
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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