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UniProtKB - Q9CBU1 (CDSA_MYCLE)
Protein
Phosphatidate cytidylyltransferase
Gene
cdsA
Organism
Mycobacterium leprae (strain TN)
Status
Functioni
Catalytic activityi
- EC:2.7.7.41
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate. This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- phosphatidate cytidylyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidate cytidylyltransferase (EC:2.7.7.41)Alternative name(s): CDP-DAG synthase CDP-DG synthase CDP-diacylglycerol synthase Short name: CDS CDP-diglyceride pyrophosphorylase CDP-diglyceride synthase CTP:phosphatidate cytidylyltransferase |
Gene namesi | Name:cdsA Ordered Locus Names:ML1589 |
Organismi | Mycobacterium leprae (strain TN) |
Taxonomic identifieri | 272631 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › |
Proteomesi |
|
Organism-specific databases
Lepromai | ML1589 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 37 – 57 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 58 – 78 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 85 – 105 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 110 – 130 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 157 – 177 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 186 – 206 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 223 – 243 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 247 – 267 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090742 | 1 – 312 | Phosphatidate cytidylyltransferaseAdd BLAST | 312 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 31 | DisorderedSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the CDS family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0575, Bacteria |
HOGENOMi | CLU_037294_0_0_11 |
OMAi | FGKHPMA |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9CBU1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASTDPGTGT PLDESVPGIK RAMRQSTKNT PRAGRNLPAA IAVGLSIGGV
60 70 80 90 100
LVATLVFAPR IWVVLCAGAI FVASHEVVRR LREAGYVIPA IPLLIGGQFT
110 120 130 140 150
VWLTWPYRTV GALAGFGATV VVCMIWRLVM HDNSKQHESR EALAGPPVSN
160 170 180 190 200
YLRDASATVF LAAWVPLFAS FAALLVYPKD GAGRVFCLMI AVVASDVGGY
210 220 230 240 250
TVGVLFGKHP LVPRISPNKS WEGFAGSLVC GTTATILTAT FLAGKTPWVG
260 270 280 290 300
ALLSFVLVLT CTLGDLVESQ VKRDLGIKDM GRLLPGHGGL MDRLDGVLPS
310
AVVAWTMLTL LP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL583922 Genomic DNA Translation: CAC30540.1 |
PIRi | G87107 |
RefSeqi | NP_302096.1, NC_002677.1 WP_010908417.1, NC_002677.1 |
Genome annotation databases
EnsemblBacteriai | CAC30540; CAC30540; CAC30540 |
KEGGi | mle:ML1589 |
PATRICi | fig|272631.5.peg.2997 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL583922 Genomic DNA Translation: CAC30540.1 |
PIRi | G87107 |
RefSeqi | NP_302096.1, NC_002677.1 WP_010908417.1, NC_002677.1 |
3D structure databases
AlphaFoldDBi | Q9CBU1 |
SMRi | Q9CBU1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 272631.ML1589 |
Genome annotation databases
EnsemblBacteriai | CAC30540; CAC30540; CAC30540 |
KEGGi | mle:ML1589 |
PATRICi | fig|272631.5.peg.2997 |
Organism-specific databases
Lepromai | ML1589 |
Phylogenomic databases
eggNOGi | COG0575, Bacteria |
HOGENOMi | CLU_037294_0_0_11 |
OMAi | FGKHPMA |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDSA_MYCLE | |
Accessioni | Q9CBU1Primary (citable) accession number: Q9CBU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 14, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families