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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.By similarity

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1832-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase (EC:3.2.2.27)
Short name:
UDG
Gene namesi
Name:ung
Ordered Locus Names:ML1675
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1675

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761181 – 227Uracil-DNA glycosylaseAdd BLAST227

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1675

Structurei

3D structure databases

ProteinModelPortaliQ9CBS3
SMRiQ9CBS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF
OrthoDBiPOG091H03VL

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CBS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTARPLSELV EQGWAAALEP VVDQVAEMGR FLRAEIAAGR RYLPAGHSVL
60 70 80 90 100
RAFTYPFDNV RVLIVGQDPY PTPGHAVGLS FSVAPDVRPL PRSLANVFDE
110 120 130 140 150
YTADLGYPLP VCGDLTPWAQ RGVLLLNRVL TVRPSNPASH RGKGWEVITE
160 170 180 190 200
CAIRALAARS EPMVAILWGR DAATLKPLLT VDNCVVIESP HPSPLSASRG
210 220
FFGSRPFSRT NEILVGMGAG PINWRLP
Length:227
Mass (Da):24,655
Last modified:June 1, 2001 - v1
Checksum:iF54B7F0AE1CE43BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583923 Genomic DNA Translation: CAC30628.1
PIRiE87118
RefSeqiNP_302149.1, NC_002677.1
WP_010908470.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30628; CAC30628; CAC30628
GeneIDi910041
KEGGimle:ML1675
PATRICifig|272631.5.peg.3167

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583923 Genomic DNA Translation: CAC30628.1
PIRiE87118
RefSeqiNP_302149.1, NC_002677.1
WP_010908470.1, NC_002677.1

3D structure databases

ProteinModelPortaliQ9CBS3
SMRiQ9CBS3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1675

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30628; CAC30628; CAC30628
GeneIDi910041
KEGGimle:ML1675
PATRICifig|272631.5.peg.3167

Organism-specific databases

LepromaiML1675

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF
OrthoDBiPOG091H03VL

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1832-MONOMER

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUNG_MYCLE
AccessioniPrimary (citable) accession number: Q9CBS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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