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UniProtKB - Q9CAV6 (WNK1_ARATH)
Protein
Serine/threonine-protein kinase WNK1
Gene
WNK1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Regulates flowering time by modulating the photoperiod pathway. Phosphorylates APRR3.
3 PublicationsCaution
Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 154 | ATPBy similarity | 1 | |
Active sitei | 171 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 104 – 107 | ATPBy similarity | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: TAIR
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: TAIR
- protein serine kinase activity Source: RHEA
GO - Biological processi
- circadian rhythm Source: TAIR
- intracellular signal transduction Source: GO_Central
- protein phosphorylation Source: TAIR
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase WNK1 (EC:2.7.11.1)Short name: AtWNK1 Alternative name(s): Protein kinase with no lysine 1 |
Gene namesi | Name:WNK1 Ordered Locus Names:At3g04910 ORF Names:T9J14.14 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G04910 |
TAIRi | locus:2114845, AT3G04910 |
Pathology & Biotechi
Disruption phenotypei
Plants display delayed flowering and altered expression of genes involved in the photoperiod flowering pathway, such as ELF4, TOC1, CO and FT.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000351659 | 1 – 700 | Serine/threonine-protein kinase WNK1Add BLAST | 700 |
Post-translational modificationi
Autophosphorylated.
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9CAV6 |
ProteomicsDBi | 242677 [Q9CAV6-1] |
PTM databases
iPTMneti | Q9CAV6 |
Expressioni
Inductioni
Expressed with a circadian rhythm showing a peak in the evening.2 Publications
Gene expression databases
ExpressionAtlasi | Q9CAV6, baseline and differential |
Genevisiblei | Q9CAV6, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4986, 2 interactors |
STRINGi | 3702.AT3G04910.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 281 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 258 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 314 – 345 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 551 – 575 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 647 – 666 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0584, Eukaryota |
HOGENOMi | CLU_000288_142_2_1 |
InParanoidi | Q9CAV6 |
OMAi | HCEVDAQ |
OrthoDBi | 695382at2759 |
PhylomeDBi | Q9CAV6 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketNote: A number of isoforms are produced. According to EST sequences.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9CAV6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNNLSYLEPD YSEFVEVDPT GRYGRYNEVL GKGASKTVYR AFDEYEGIEV
60 70 80 90 100
AWNQVKLYDF LQSPEDLERL YCEIHLLKTL KHKNIMKFYT SWVDTANRNI
110 120 130 140 150
NFVTELFTSG TLRQYRLRHK RVNIRAMKHW CRQILRGLHY LHSHDPPVIH
160 170 180 190 200
RDLKCDNIFV NGNQGEVKIG DLGLAAILRK SHAAHCVGTP EFMAPEVYEE
210 220 230 240 250
AYNELVDIYS FGMCILEMVT FDYPYSECTH PAQIYKKVMS GKKPDALYKV
260 270 280 290 300
KDPEVKCFIE KCLATVSLRV SARELLDDPF LRIDDGEFDL RSVDMEDSVG
310 320 330 340 350
PLYRQPHHLP DYYNYPSNSS SLNRQYSNGN YPSNSSSLNR QYSNGYNSHH
360 370 380 390 400
EYQNGWAYNP AETEETHGIE LFESRNNDDQ EEEKKSGNVD ITIKGKRRDD
410 420 430 440 450
GGLFLRLRIA DKEGRVRNIY FPFDIETDTA LSVATEMVAE LDMDDHGVTK
460 470 480 490 500
IANMIDGEIS SLVPSWRPGP EFEECLAAAA AANAASICNN CVSNRTSMGS
510 520 530 540 550
VMDFLRTNPG ANVIQCCRNG CGETHGRFEE ITIRETEVRL RELWKLQQQQ
560 570 580 590 600
ESRELSSIDS GHNHSEEEEE EEVLYEDPEN MFSCEAGNEI NHISGSGSFS
610 620 630 640 650
FMPSKYCDEP SEKTENQVQQ ELRWLKAKCQ IELRDIQDEQ LKTRWPESGE
660 670 680 690 700
EVEISPKDGF LGSVSGLGRE EDTVKEMFGE RLVPKCLKRT TSLPVDAIDS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB3H6U2 | B3H6U2_ARATH | With no lysine (K) kinase 1 | WNK1 ATWNK1, with no lysine (K) kinase 1, ZIK4, At3g04910, T9J14.14 | 574 | Annotation score: | ||
F4J622 | F4J622_ARATH | With no lysine (K) kinase 1 | WNK1 ATWNK1, with no lysine (K) kinase 1, ZIK4, At3g04910, T9J14.14 | 677 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB084266 mRNA Translation: BAB91125.1 AC009465 Genomic DNA Translation: AAG51416.1 CP002686 Genomic DNA Translation: AEE74155.1 |
RefSeqi | NP_187142.1, NM_111363.4 [Q9CAV6-1] |
Genome annotation databases
EnsemblPlantsi | AT3G04910.1; AT3G04910.1; AT3G04910 [Q9CAV6-1] |
GeneIDi | 819651 |
Gramenei | AT3G04910.1; AT3G04910.1; AT3G04910 [Q9CAV6-1] |
KEGGi | ath:AT3G04910 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB084266 mRNA Translation: BAB91125.1 AC009465 Genomic DNA Translation: AAG51416.1 CP002686 Genomic DNA Translation: AEE74155.1 |
RefSeqi | NP_187142.1, NM_111363.4 [Q9CAV6-1] |
3D structure databases
SMRi | Q9CAV6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4986, 2 interactors |
STRINGi | 3702.AT3G04910.1 |
PTM databases
iPTMneti | Q9CAV6 |
Proteomic databases
PaxDbi | Q9CAV6 |
ProteomicsDBi | 242677 [Q9CAV6-1] |
Genome annotation databases
EnsemblPlantsi | AT3G04910.1; AT3G04910.1; AT3G04910 [Q9CAV6-1] |
GeneIDi | 819651 |
Gramenei | AT3G04910.1; AT3G04910.1; AT3G04910 [Q9CAV6-1] |
KEGGi | ath:AT3G04910 |
Organism-specific databases
Araporti | AT3G04910 |
TAIRi | locus:2114845, AT3G04910 |
Phylogenomic databases
eggNOGi | KOG0584, Eukaryota |
HOGENOMi | CLU_000288_142_2_1 |
InParanoidi | Q9CAV6 |
OMAi | HCEVDAQ |
OrthoDBi | 695382at2759 |
PhylomeDBi | Q9CAV6 |
Miscellaneous databases
PROi | PR:Q9CAV6 |
Gene expression databases
ExpressionAtlasi | Q9CAV6, baseline and differential |
Genevisiblei | Q9CAV6, AT |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WNK1_ARATH | |
Accessioni | Q9CAV6Primary (citable) accession number: Q9CAV6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 14, 2008 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families