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Entry version 113 (29 Sep 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Hypersensitive-induced response protein 2

Gene

HIR2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hypersensitive-induced response protein 2
Short name:
AtHIR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HIR2
Ordered Locus Names:At1g69840
ORF Names:T17F3.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G69840

The Arabidopsis Information Resource

More...
TAIRi
locus:2196749, AT1G69840

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003985972 – 286Hypersensitive-induced response protein 2Add BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CAR7

PRoteomics IDEntifications database

More...
PRIDEi
Q9CAR7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
230222

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9CAR7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9CAR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9CAR7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CAR7, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-interacts and forms heteromers.

Interacts with AHK2.

Interacts with NB-LRR class of R proteins (e.g. RPS2 or RPM1) before R proteins are activated by the effectors.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
28541, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9CAR7, 3 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G69840.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9CAR7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili156 – 190Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2620, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024949_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CAR7

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMMMMTQ

Database of Orthologous Groups

More...
OrthoDBi
1237942at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CAR7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.479.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001107, Band_7
IPR036013, Band_7/SPFH_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01145, Band_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00244, PHB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117892, SSF117892, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CAR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQALGCIQV DQSNVAIKET FGKFDEVLEP GCHCLPWCLG SQVAGHLSLR
60 70 80 90 100
VQQLDVRCET KTKDNVFVTV VASIQYRALA ESAQDAFYKL SNTRNQIQAY
110 120 130 140 150
VFDVIRASVP KLDLDSTFEQ KNDIAKTVET ELEKAMSHYG YEIVQTLIVD
160 170 180 190 200
IEPDVHVKRA MNEINAASRM REAASEKAEA EKILQIKRAE GEAESKYLSG
210 220 230 240 250
MGIARQRQAI VDGLRNSVLA FSESVPGTSS KDVMDMVLVT QYFDTLKEIG
260 270 280
ASSKSNSVFI PHGPGAVRDI ASQIRDGLLQ GNSAAE
Length:286
Mass (Da):31,406
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i970254272F65D211
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti258V → E in BAH19919 (PubMed:19423640).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010675 Genomic DNA Translation: AAG52556.1
CP002684 Genomic DNA Translation: AEE34984.1
CP002684 Genomic DNA Translation: AEE34985.1
CP002684 Genomic DNA Translation: AEE34986.1
CP002684 Genomic DNA Translation: AEE34987.1
CP002684 Genomic DNA Translation: AEE34988.1
CP002684 Genomic DNA Translation: AEE34989.1
CP002684 Genomic DNA Translation: AEE34990.1
AY099840 mRNA Translation: AAM20691.1
BT000336 mRNA Translation: AAN15655.1
AK317238 mRNA Translation: BAH19919.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F96720

NCBI Reference Sequences

More...
RefSeqi
NP_001077802.1, NM_001084333.2
NP_001077803.1, NM_001084334.2
NP_001185358.1, NM_001198429.1
NP_177142.1, NM_105652.6
NP_849870.1, NM_179539.4
NP_974116.1, NM_202387.4
NP_974117.1, NM_202388.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G69840.1; AT1G69840.1; AT1G69840
AT1G69840.2; AT1G69840.2; AT1G69840
AT1G69840.3; AT1G69840.3; AT1G69840
AT1G69840.4; AT1G69840.4; AT1G69840
AT1G69840.5; AT1G69840.5; AT1G69840
AT1G69840.6; AT1G69840.6; AT1G69840
AT1G69840.7; AT1G69840.7; AT1G69840

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
843320

Gramene; a comparative resource for plants

More...
Gramenei
AT1G69840.1; AT1G69840.1; AT1G69840
AT1G69840.2; AT1G69840.2; AT1G69840
AT1G69840.3; AT1G69840.3; AT1G69840
AT1G69840.4; AT1G69840.4; AT1G69840
AT1G69840.5; AT1G69840.5; AT1G69840
AT1G69840.6; AT1G69840.6; AT1G69840
AT1G69840.7; AT1G69840.7; AT1G69840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G69840

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010675 Genomic DNA Translation: AAG52556.1
CP002684 Genomic DNA Translation: AEE34984.1
CP002684 Genomic DNA Translation: AEE34985.1
CP002684 Genomic DNA Translation: AEE34986.1
CP002684 Genomic DNA Translation: AEE34987.1
CP002684 Genomic DNA Translation: AEE34988.1
CP002684 Genomic DNA Translation: AEE34989.1
CP002684 Genomic DNA Translation: AEE34990.1
AY099840 mRNA Translation: AAM20691.1
BT000336 mRNA Translation: AAN15655.1
AK317238 mRNA Translation: BAH19919.1
PIRiF96720
RefSeqiNP_001077802.1, NM_001084333.2
NP_001077803.1, NM_001084334.2
NP_001185358.1, NM_001198429.1
NP_177142.1, NM_105652.6
NP_849870.1, NM_179539.4
NP_974116.1, NM_202387.4
NP_974117.1, NM_202388.4

3D structure databases

SMRiQ9CAR7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi28541, 3 interactors
IntActiQ9CAR7, 3 interactors
STRINGi3702.AT1G69840.3

PTM databases

iPTMnetiQ9CAR7
SwissPalmiQ9CAR7

Proteomic databases

PaxDbiQ9CAR7
PRIDEiQ9CAR7
ProteomicsDBi230222

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
843320

Genome annotation databases

EnsemblPlantsiAT1G69840.1; AT1G69840.1; AT1G69840
AT1G69840.2; AT1G69840.2; AT1G69840
AT1G69840.3; AT1G69840.3; AT1G69840
AT1G69840.4; AT1G69840.4; AT1G69840
AT1G69840.5; AT1G69840.5; AT1G69840
AT1G69840.6; AT1G69840.6; AT1G69840
AT1G69840.7; AT1G69840.7; AT1G69840
GeneIDi843320
GrameneiAT1G69840.1; AT1G69840.1; AT1G69840
AT1G69840.2; AT1G69840.2; AT1G69840
AT1G69840.3; AT1G69840.3; AT1G69840
AT1G69840.4; AT1G69840.4; AT1G69840
AT1G69840.5; AT1G69840.5; AT1G69840
AT1G69840.6; AT1G69840.6; AT1G69840
AT1G69840.7; AT1G69840.7; AT1G69840
KEGGiath:AT1G69840

Organism-specific databases

AraportiAT1G69840
TAIRilocus:2196749, AT1G69840

Phylogenomic databases

eggNOGiKOG2620, Eukaryota
HOGENOMiCLU_024949_5_1_1
InParanoidiQ9CAR7
OMAiEMMMMTQ
OrthoDBi1237942at2759
PhylomeDBiQ9CAR7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9CAR7

Gene expression databases

ExpressionAtlasiQ9CAR7, baseline and differential
GenevisibleiQ9CAR7, AT

Family and domain databases

Gene3Di3.30.479.30, 1 hit
InterProiView protein in InterPro
IPR001107, Band_7
IPR036013, Band_7/SPFH_dom_sf
PfamiView protein in Pfam
PF01145, Band_7, 1 hit
SMARTiView protein in SMART
SM00244, PHB, 1 hit
SUPFAMiSSF117892, SSF117892, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIR2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CAR7
Secondary accession number(s): B9DGQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2001
Last modified: September 29, 2021
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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