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Entry version 129 (08 May 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Disease resistance protein RML1B

Gene

RLM1B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TIR-NB-LRR receptor-like protein that confers resistance to the pathogen Leptosphaeria maculans (blackleg disease).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • defense response to fungus Source: TAIR
  • signal transduction Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPlant defense
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disease resistance protein RML1BCurated
Alternative name(s):
Protein RESISTANCE TO LEPTOSPHAERIA MACULANS 1B1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RLM1B1 Publication
Ordered Locus Names:At1g63880Imported
ORF Names:T12P18.10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G63880

The Arabidopsis Information Resource

More...
TAIRi
locus:2195468 AT1G63880

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype under normal growth conditions, but mutant plants are susceptible to the pathogen Leptosphaeria maculans.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004333761 – 1017Disease resistance protein RML1BAdd BLAST1017

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CAK1

PRoteomics IDEntifications database

More...
PRIDEi
Q9CAK1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9CAK1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CAK1 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G63880.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 150TIRPROSITE-ProRule annotationAdd BLAST139
Domaini191 – 447NB-ARCSequence analysisAdd BLAST257
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati539 – 562LRR 1Sequence analysisAdd BLAST24
Repeati583 – 605LRR 2Sequence analysisAdd BLAST23
Repeati606 – 628LRR 3Sequence analysisAdd BLAST23
Repeati629 – 652LRR 4Sequence analysisAdd BLAST24
Repeati654 – 675LRR 5Sequence analysisAdd BLAST22
Repeati676 – 698LRR 6Sequence analysisAdd BLAST23
Repeati699 – 724LRR 7Sequence analysisAdd BLAST26
Repeati738 – 760LRR 8Sequence analysisAdd BLAST23
Repeati761 – 782LRR 9Sequence analysisAdd BLAST22
Repeati784 – 809LRR 10Sequence analysisAdd BLAST26

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGA8 Eukaryota
COG4886 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000064702

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CAK1

Database of Orthologous Groups

More...
OrthoDBi
258604at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CAK1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10140, 1 hit
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011713 Leu-rich_rpt_3
IPR032675 LRR_dom_sf
IPR002182 NB-ARC
IPR027417 P-loop_NTPase
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07725 LRR_3, 1 hit
PF00931 NB-ARC, 1 hit
PF01582 TIR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF52200 SSF52200, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CAK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPSSFSSQ NYKFNVFASF HGPDVRKTLL SHIRLQFNRN GITMFDDQKI
60 70 80 90 100
VRSATIGPSL VEAIKESRIS IVILSKKYAS SSWCLDELVE ILECKKAMGQ
110 120 130 140 150
IVMTIFYGVD PSDVRKQIGK FGIAFNETCA RKTEEERQKW SKALNQVSNI
160 170 180 190 200
AGEDFLRWDN EAIMIEKIAR DVLDKLNATP SRDFDGMVGI EAHLREIKSL
210 220 230 240 250
LDLDNVEVKI VAIAGPAGIG KTTIARALYG LLSKRFQLSC FVDNLRGSYH
260 270 280 290 300
SGFDEYGFKL HLQEQFLSKV LNQSGMRICH LGAIKENLSD QRVLIILDDV
310 320 330 340 350
NKLKQLEALA NETTWFGPGS RIVVTTENKE LLQQHGINNT YHVGFPSDED
360 370 380 390 400
ALKILCSYAF KQTSPRHGFE ELSESVTKLC GKLPLGLCVV GSSLRGKKED
410 420 430 440 450
EWEDVVTRLE TILDQDIEDV LRVGYESLDE NAQTLFLHIA IFFNKEDGDL
460 470 480 490 500
VKTMFAESDL DVKYGLKILE NRSLIKMKIF SNGDTKIVMH RLLQQMGKRA
510 520 530 540 550
IQKQEPWERQ ILIDAREICH VLEHAKGTGW NVHGMSFDIS RISEVSIRKK
560 570 580 590 600
AFKRMPNLQF LKVYKSKDDG NNRMHVPEEM DFPCLLRLLD WKAYPSKSLP
610 620 630 640 650
PTFNPEHLVE LNMHSSQLEY LWQGTQPLKN LKKMDLSQSK NLKQLPDLSN
660 670 680 690 700
ATNLEYLYLM GCESLIEIPS SISHLHKLEM LATVGCINLE VIPAHMNLES
710 720 730 740 750
LQTVYLGGCS RLRNIPVMST NIRYLFITNT AVEGVPLCPG LKTLDVSGSR
760 770 780 790 800
NFKGLLTHLP TSLTTLNLCY TDIERIPDCF KSLHQLKGVN LRGCRRLASL
810 820 830 840 850
PELPRSLLTL VADDCESLET VFCPLNTLKA SFSFANCFKL DREARRAIIQ
860 870 880 890 900
QSFFMGKAVL PGREVPAVFD HRAKGYSLTI RPDGNPYTSF VFCVVVSRNQ
910 920 930 940 950
KSDKTIPPSL LWRRIIAQDE GYPVEVWNRI GDVFKYRTEH LLIFHFDFLE
960 970 980 990 1000
FDNRDIVFEF SSESHDFDII ECGAKVLAEK SIKESYESGS DQAFEDDVVF
1010
EPSKAFGDEK YGDCCIL
Length:1,017
Mass (Da):115,415
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C1AF3178F70F7D4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8AN87A0A1P8AN87_ARATH
Disease resistance protein (TIR-NBS...
At1g63880, T12P18.10, T12P18_10
765Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti312E → G in BAC43641 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010852 Genomic DNA Translation: AAG52448.1
CP002684 Genomic DNA Translation: AEE34163.1
AK119065 mRNA Translation: BAC43641.2

Protein sequence database of the Protein Information Resource

More...
PIRi
H96663

NCBI Reference Sequences

More...
RefSeqi
NP_176572.1, NM_105062.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G63880.1; AT1G63880.1; AT1G63880

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
842692

Gramene; a comparative resource for plants

More...
Gramenei
AT1G63880.1; AT1G63880.1; AT1G63880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G63880

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010852 Genomic DNA Translation: AAG52448.1
CP002684 Genomic DNA Translation: AEE34163.1
AK119065 mRNA Translation: BAC43641.2
PIRiH96663
RefSeqiNP_176572.1, NM_105062.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT1G63880.1

Proteomic databases

PaxDbiQ9CAK1
PRIDEiQ9CAK1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G63880.1; AT1G63880.1; AT1G63880
GeneIDi842692
GrameneiAT1G63880.1; AT1G63880.1; AT1G63880
KEGGiath:AT1G63880

Organism-specific databases

AraportiAT1G63880
TAIRilocus:2195468 AT1G63880

Phylogenomic databases

eggNOGiENOG410IGA8 Eukaryota
COG4886 LUCA
HOGENOMiHOG000064702
InParanoidiQ9CAK1
OrthoDBi258604at2759
PhylomeDBiQ9CAK1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9CAK1

Gene expression databases

ExpressionAtlasiQ9CAK1 baseline and differential
GenevisibleiQ9CAK1 AT

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011713 Leu-rich_rpt_3
IPR032675 LRR_dom_sf
IPR002182 NB-ARC
IPR027417 P-loop_NTPase
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF07725 LRR_3, 1 hit
PF00931 NB-ARC, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52200 SSF52200, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRLM1B_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CAK1
Secondary accession number(s): Q7FKS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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