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Protein

Protein FLOWERING LOCUS D

Gene

FLD

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable histone demethylase that promotes flowering independently of the photoperiod and vernalization pathways by repressing FLOWERING LOCUS C (FLC), a floral repressor that blocks the transition from vegetative to reproductive development. Probably mediates histone H3 'Lys-4' demethylation at FLC locus. Seems to act in partial redundancy with LDL1 and LDL2 to repress FLC expression. Required for histone H4 deacetylation of FLC locus. May be a component of the histone deacetylase complex.3 Publications

Cofactori

FADCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei214FADBy similarity1
Binding sitei216FADBy similarity1
Binding sitei222FADBy similarity1
Binding sitei595FADBy similarity1

GO - Molecular functioni

  • DNA binding Source: InterPro
  • oxidoreductase activity Source: GO_Central

GO - Biological processi

  • histone deacetylation Source: TAIR
  • vegetative to reproductive phase transition of meristem Source: TAIR

Keywordsi

Molecular functionChromatin regulator, Oxidoreductase, Repressor
Biological processTranscription, Transcription regulation
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-ATH-3214842 HDMs demethylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FLOWERING LOCUS D (EC:1.-.-.-)
Alternative name(s):
Protein SUPPRESSOR OF OVEREXPRESSED FCA 1
Gene namesi
Name:FLD
Synonyms:SOF1
Ordered Locus Names:At3g10390
ORF Names:F13M14.34, F14P13.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G10390
TAIRilocus:2075870 AT3G10390

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi287K → R: Loss of sumoylation; when associated with R-693 and R-770. 1 Publication1
Mutagenesisi428P → L in sof1/fld-6; weak allele that suppresses the down-regulation of FLC by FCA. 1 Publication1
Mutagenesisi693K → R: Loss of sumoylation; when associated with R-287 and R-770. 1 Publication1
Mutagenesisi770K → R: Loss of sumoylation; when associated with R-287 and R-693. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003428951 – 789Protein FLOWERING LOCUS DAdd BLAST789

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki693Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki770Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationi

Sumoylated at Lys-287, Lys-693 and Lys-770 by SIZ1. Sumoylation alters its activity and the histone H4 acetylation status of FLC locus, promoting FLC expression.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9CAE3
PRIDEiQ9CAE3

Expressioni

Gene expression databases

ExpressionAtlasiQ9CAE3 baseline and differential
GenevisibleiQ9CAE3 AT

Interactioni

Protein-protein interaction databases

BioGridi5536, 2 interactors
STRINGi3702.AT3G10390.1

Structurei

3D structure databases

ProteinModelPortaliQ9CAE3
SMRiQ9CAE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 177SWIRMPROSITE-ProRule annotationAdd BLAST102

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi712 – 717Poly-Gln6

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
HOGENOMiHOG000029979
InParanoidiQ9CAE3
KOiK11450
OMAiIVHTIRY
OrthoDBiEOG093603FU
PhylomeDBiQ9CAE3

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR009057 Homeobox-like_sf
IPR007526 SWIRM
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PF04433 SWIRM, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS50934 SWIRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CAE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSFSAPKKR RRGRSQRSMS SLNSLPVPNV GLLPGNSNFV SSSASSSGRF
60 70 80 90 100
NVEVVNGSNQ TVKSYPGIGD EIITINKEAT TEALLALTAG FPADSLTEEE
110 120 130 140 150
IEFGVVPIVG GIEQVNYILI RNHIISKWRE NISSWVTKEM FLNSIPKHCS
160 170 180 190 200
SLLDSAYNYL VTHGYINFGI AQAIKDKFPA QSSKSSVIIV GAGLSGLAAA
210 220 230 240 250
RQLMRFGFKV TVLEGRKRPG GRVYTKKMEA NRVGAAADLG GSVLTGTLGN
260 270 280 290 300
PLGIIARQLG SSLYKVRDKC PLYRVDGKPV DPDVDIKVEV AFNQLLDKAS
310 320 330 340 350
KLRQLMGDVS MDVSLGAALE TFRQVSGNDV ATEEMGLFNW HLANLEYANA
360 370 380 390 400
GLVSKLSLAF WDQDDPYDMG GDHCFLPGGN GRLVQALAEN VPILYEKTVQ
410 420 430 440 450
TIRYGSNGVK VTAGNQVYEG DMVLCTVPLG VLKNGSIKFV PELPQRKLDC
460 470 480 490 500
IKRLGFGLLN KVAMLFPYVF WSTDLDTFGH LTEDPNYRGE FFLFYSYAPV
510 520 530 540 550
AGGALLIALV AGEAAHKFET MPPTDAVTRV LHILRGIYEP QGINVPDPLQ
560 570 580 590 600
TVCTRWGGDP FSLGSYSNVA VGASGDDYDI LAESVGDGRL FFAGEATTRR
610 620 630 640 650
YPATMHGAFV TGLREAANMA QSAKARGIRK RIDRNPSRNA HSCAILLADL
660 670 680 690 700
FRDPDLEFGS FCIIFSRRNP DPKSPAILRV TLSEPRKRNE DPKADQHSNK
710 720 730 740 750
ILFQQLQSHF NQQQQIQVYT LLTRQQALDL REVRGGDEKR LYYLCETLGV
760 770 780
KLVGRKGLGV GADSVIASIK AERTGRKLPS SSTSGTKSG
Length:789
Mass (Da):86,037
Last modified:June 1, 2001 - v1
Checksum:i937FCFCF0E7A8EFF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1I9LNW6A0A1I9LNW6_ARATH
Protein FLOWERING locus D-like prot...
FLD FLOWERING LOCUS D, Reduced Systemic immunity 1, RSI1, At3g10390
936Annotation score:
A0A1I9LNW7A0A1I9LNW7_ARATH
Protein FLOWERING locus D-like prot...
FLD FLOWERING LOCUS D, Reduced Systemic immunity 1, RSI1, At3g10390
925Annotation score:

Sequence cautioni

The sequence AAF02805 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AEE74899 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti640A → T in strain: cv. Lz-0. 1 Publication1
Natural varianti686R → L in strain: cv. Lz-0. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY849996 Genomic DNA Translation: AAX51266.1
AY849997 Genomic DNA Translation: AAX51267.1
AC009400 Genomic DNA Translation: AAF02805.1 Different initiation.
AC011560 Genomic DNA Translation: AAG51395.1
CP002686 Genomic DNA Translation: AEE74899.1 Sequence problems.
CP002686 Genomic DNA Translation: ANM64276.1
RefSeqiNP_001326316.1, NM_001337874.1
NP_187650.4, NM_111874.4
UniGeneiAt.39938

Genome annotation databases

EnsemblPlantsiAT3G10390.4; AT3G10390.4; AT3G10390
GeneIDi820202
GrameneiAT3G10390.4; AT3G10390.4; AT3G10390
KEGGiath:AT3G10390

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY849996 Genomic DNA Translation: AAX51266.1
AY849997 Genomic DNA Translation: AAX51267.1
AC009400 Genomic DNA Translation: AAF02805.1 Different initiation.
AC011560 Genomic DNA Translation: AAG51395.1
CP002686 Genomic DNA Translation: AEE74899.1 Sequence problems.
CP002686 Genomic DNA Translation: ANM64276.1
RefSeqiNP_001326316.1, NM_001337874.1
NP_187650.4, NM_111874.4
UniGeneiAt.39938

3D structure databases

ProteinModelPortaliQ9CAE3
SMRiQ9CAE3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5536, 2 interactors
STRINGi3702.AT3G10390.1

Proteomic databases

PaxDbiQ9CAE3
PRIDEiQ9CAE3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G10390.4; AT3G10390.4; AT3G10390
GeneIDi820202
GrameneiAT3G10390.4; AT3G10390.4; AT3G10390
KEGGiath:AT3G10390

Organism-specific databases

AraportiAT3G10390
TAIRilocus:2075870 AT3G10390

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
HOGENOMiHOG000029979
InParanoidiQ9CAE3
KOiK11450
OMAiIVHTIRY
OrthoDBiEOG093603FU
PhylomeDBiQ9CAE3

Enzyme and pathway databases

ReactomeiR-ATH-3214842 HDMs demethylate histones

Miscellaneous databases

PROiPR:Q9CAE3

Gene expression databases

ExpressionAtlasiQ9CAE3 baseline and differential
GenevisibleiQ9CAE3 AT

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR009057 Homeobox-like_sf
IPR007526 SWIRM
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PF04433 SWIRM, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS50934 SWIRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFLD_ARATH
AccessioniPrimary (citable) accession number: Q9CAE3
Secondary accession number(s): F4J3R3, Q58T18, Q9SS50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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