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Entry version 121 (25 May 2022)
Sequence version 1 (01 Jun 2001)
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Protein

Protein PIN-LIKES 3

Gene

PILS3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAuxin signaling pathway, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PIN-LIKES 31 Publication
Alternative name(s):
Auxin efflux carrier-like protein 31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PILS3
Ordered Locus Names:At1g76520Imported
ORF Names:F14G6.12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G76520

The Arabidopsis Information Resource

More...
TAIRi
locus:2011731, AT1G76520

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14Lumenal1 PublicationAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 43Cytoplasmic1 Publication8
Transmembranei44 – 61HelicalSequence analysisAdd BLAST18
Topological domaini62 – 76Lumenal1 PublicationAdd BLAST15
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 107Cytoplasmic1 Publication10
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 144Lumenal1 PublicationAdd BLAST16
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 227Cytoplasmic1 PublicationAdd BLAST62
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 265Lumenal1 PublicationAdd BLAST17
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 297Cytoplasmic1 PublicationAdd BLAST11
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 331Lumenal1 PublicationAdd BLAST13
Transmembranei332 – 352HelicalSequence analysisAdd BLAST21
Topological domaini353 – 364Cytoplasmic1 PublicationAdd BLAST12
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 390Lumenal1 Publication5

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004364981 – 390Protein PIN-LIKES 3Add BLAST390

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C9K5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
235111 [Q9C9K5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C9K5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in seedlings, rosette and cauline leaves, flowers and siliques.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by auxin application.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C9K5, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9C9K5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G76520.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q9C9K5

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2722, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_044945_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C9K5

Identification of Orthologs from Complete Genome Data

More...
OMAi
MGSIYIW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C9K5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004776, Mem_trans
IPR045033, PILS1/3/4/5/7

The PANTHER Classification System

More...
PANTHERi
PTHR31651, PTHR31651, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03547, Mem_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9C9K5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKLLELFIT SSKPVVEILL ITSVGFYMAL DGVNLLGHDA RKYLNNIVFY
60 70 80 90 100
VFSPSLIGSR LADSVTYESL VKMWFMPVNV LLTFIIGSLL GWIVIVITKP
110 120 130 140 150
PSHLRGLILG CCAAGNLGNM PLIIIPAVCK EKGGPFGDPE SCQKYGMGYV
160 170 180 190 200
ALSMAMGSIY IWTYVYNLMR VLSNSPVETP PSVESNYDSY KVPLISSKEE
210 220 230 240 250
ENNQKAGRWE KVKRRLVSLS QKVNLKTIFA PSTIAAMIAL VIGLITPLRK
260 270 280 290 300
LIIGTEAPLR VLQDSVTLVG DGAVPAMTMI IGGNLLKGLR SSGMKMSSII
310 320 330 340 350
GVLVARYVLL PMSGVLIVRG AYKLDLVTSE PLYQFVLLLQ YAVPPAMNLG
360 370 380 390
TITQLFGTGE SECSVIMLWT YSLASIALTV WPTFFMWLVA
Length:390
Mass (Da):42,632
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9080F589B23F790F
GO
Isoform 2 (identifier: Q9C9K5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-155: A → AYLVTYQ
     206-249: AGRWEKVKRR...LVIGLITPLR → VSSHMHMISN...IGFTVTKSQP
     250-390: Missing.

Show »
Length:255
Mass (Da):28,229
Checksum:i76933246F0D7F245
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058378155A → AYLVTYQ in isoform 2. 1
Alternative sequenceiVSP_058379206 – 249AGRWE…ITPLR → VSSHMHMISNYSFIKVGSDC VYMTGWEVGKSQAEIGFTVT KSQP in isoform 2. Add BLAST44
Alternative sequenceiVSP_058380250 – 390Missing in isoform 2. Add BLAST141

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC015450 Genomic DNA Translation: AAG51955.1
CP002684 Genomic DNA Translation: AEE35854.1
CP002684 Genomic DNA Translation: AEE35855.1
AY099725 mRNA Translation: AAM20576.1
BT000295 mRNA Translation: AAN15614.1
AK226892 mRNA Translation: BAE98969.1
AK318926 mRNA Translation: BAH57041.1

Protein sequence database of the Protein Information Resource

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PIRi
B96793

NCBI Reference Sequences

More...
RefSeqi
NP_565133.1, NM_106302.5 [Q9C9K5-1]
NP_849892.1, NM_179561.4 [Q9C9K5-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G76520.1; AT1G76520.1; AT1G76520 [Q9C9K5-1]
AT1G76520.2; AT1G76520.2; AT1G76520 [Q9C9K5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
843985

Gramene; a comparative resource for plants

More...
Gramenei
AT1G76520.1; AT1G76520.1; AT1G76520 [Q9C9K5-1]
AT1G76520.2; AT1G76520.2; AT1G76520 [Q9C9K5-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G76520

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015450 Genomic DNA Translation: AAG51955.1
CP002684 Genomic DNA Translation: AEE35854.1
CP002684 Genomic DNA Translation: AEE35855.1
AY099725 mRNA Translation: AAM20576.1
BT000295 mRNA Translation: AAN15614.1
AK226892 mRNA Translation: BAE98969.1
AK318926 mRNA Translation: BAH57041.1
PIRiB96793
RefSeqiNP_565133.1, NM_106302.5 [Q9C9K5-1]
NP_849892.1, NM_179561.4 [Q9C9K5-1]

3D structure databases

AlphaFoldDBiQ9C9K5
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

IntActiQ9C9K5, 1 interactor
STRINGi3702.AT1G76520.2

PTM databases

iPTMnetiQ9C9K5

Proteomic databases

PaxDbiQ9C9K5
ProteomicsDBi235111 [Q9C9K5-1]

Genome annotation databases

EnsemblPlantsiAT1G76520.1; AT1G76520.1; AT1G76520 [Q9C9K5-1]
AT1G76520.2; AT1G76520.2; AT1G76520 [Q9C9K5-1]
GeneIDi843985
GrameneiAT1G76520.1; AT1G76520.1; AT1G76520 [Q9C9K5-1]
AT1G76520.2; AT1G76520.2; AT1G76520 [Q9C9K5-1]
KEGGiath:AT1G76520

Organism-specific databases

AraportiAT1G76520
TAIRilocus:2011731, AT1G76520

Phylogenomic databases

eggNOGiKOG2722, Eukaryota
HOGENOMiCLU_044945_0_0_1
InParanoidiQ9C9K5
OMAiMGSIYIW
PhylomeDBiQ9C9K5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9C9K5

Gene expression databases

ExpressionAtlasiQ9C9K5, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR004776, Mem_trans
IPR045033, PILS1/3/4/5/7
PANTHERiPTHR31651, PTHR31651, 1 hit
PfamiView protein in Pfam
PF03547, Mem_trans, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPILS3_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C9K5
Secondary accession number(s): C0Z2W2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 8, 2016
Last sequence update: June 1, 2001
Last modified: May 25, 2022
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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