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Entry version 161 (31 Jul 2019)
Sequence version 1 (01 Jun 2001)
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Protein

LRR receptor-like serine/threonine-protein kinase IOS1

Gene

IOS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates negatively the abscisic acid (ABA) signaling pathway (PubMed:25274985). Required for full susceptibility to filamentous (hemi)biotrophic oomycetes (e.g. H.arabidopsidis and P.parasitica) and fungal (e.g. E.cruciferarum) pathogens, probably by triggering the repression of ABA-sensitive COLD REGULATED and RESISTANCE TO DESICCATION genes during infection, but independently of immune responses (PubMed:21711359, PubMed:25274985). Involved in BAK1-dependent and BAK1-independent microbe-associated molecular patterns (MAMPs)-triggered immunity (PTI) leading to defense responses, including callose deposition and MAPK cascade activation, toward pathogenic bacteria (e.g. P.syringae). Required for chitin-mediated PTI (PubMed:27317676).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei613ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei710Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi592 – 600ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological processAbscisic acid signaling pathway, Plant defense
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LRR receptor-like serine/threonine-protein kinase IOS11 Publication (EC:2.7.11.-PROSITE-ProRule annotation)
Alternative name(s):
Protein IMPAIRED OOMYCETE SUSCEPTIBILITY 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IOS11 Publication
Ordered Locus Names:At1g51800Imported
ORF Names:F19C24.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G51800

The Arabidopsis Information Resource

More...
TAIRi
locus:2017557 AT1G51800

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 515ExtracellularCuratedAdd BLAST492
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei516 – 536HelicalSequence analysisAdd BLAST21
Topological domaini537 – 894CytoplasmicCuratedAdd BLAST358

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Reduced infection by filamentous (hemi)biotrophic oomycetes (e.g. H.arabidopsidis and P.parasitica) and fungal (e.g. E.cruciferarum) pathogens, independently of plant defense mechanism (PubMed:21711359, PubMed:25274985). Hypersensitivity to abscisic acid (ABA), displaying enhanced ABA-mediated inhibition of seed germination, root elongation, and stomatal opening. Impaired repression of ABA-sensitive COLD REGULATED and RESISTANCE TO DESICCATION genes upon oomycete infection. No obvious modification of defense-related gene induction during pathogen attack (PubMed:25274985). Hypersusceptibility to the necrotrophic bacteria P.syringae. Defective pattern-triggered immunity (PTI) responses, delayed up-regulation of PTI marker genes, reduced callose deposition, and mitogen-activated protein kinase activation upon microbe-associated molecular patterns (MAMPs) treatment. Impaired beta-aminobutyric acid (BABA)-induced resistance and priming (PubMed:27317676).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501014786724 – 894LRR receptor-like serine/threonine-protein kinase IOS1Add BLAST871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi95N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi137N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi179N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi223N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi230N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi260N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi287N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi309N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi338N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi399N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi441N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi462N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi469N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei577PhosphothreonineBy similarity1
Modified residuei658PhosphotyrosineBy similarity1
Modified residuei744PhosphoserineBy similarity1
Modified residuei745PhosphothreonineBy similarity1
Modified residuei750PhosphothreonineBy similarity1
Modified residuei758PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C8I6

PRoteomics IDEntifications database

More...
PRIDEi
Q9C8I6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C8I6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots, cotyledons, leaves, flowers and siliques.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Predominantly expressed in tissue with fates controlled by the phytohormone abscisic acid (ABA). In roots, expressed in the radicle emerging from the testa, in the elongation zones of roots, and in root cap border cells undergoing detachment. In hypocotyls, detected only during etiolation in the dark. In cotyledons and leaves, restricted to cells surrounding stomata. In reproductive organs, observed in the style after pollination, in the abscission zones of sepals and petals, in the transmitting tract of developing fruits, and in the abscission zones of mature siliques. Also present in pollen tubes.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Accumulates during infection by filamentous (hemi)biotrophic oomycetes (e.g. H.arabidopsidis and P.parasitica) and fungal (e.g. E.cruciferarum) pathogens, being locally expressed in cells surrounding the pathogens both at early and late stages of infection (PubMed:21711359, PubMed:25274985). Induced by microbe-associated molecular patterns (MAMPs) flg22 or elf18 (PubMed:27317676).3 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C8I6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimerization.

Interacts with BAK1 and FLS2; triggers FLS2-BAK1 complex formation upon microbe-associated molecular patterns (MAMPs) treatment. Binds also to CERK1 and EFR.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9C8I6, 39 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G51800.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati431 – 457LRR 1Sequence analysisAdd BLAST27
Repeati459 – 479LRR 2Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini586 – 858Protein kinasePROSITE-ProRule annotationAdd BLAST273

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IID2 Eukaryota
COG0515 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116550

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C8I6

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIYGPFR

Database of Orthologous Groups

More...
OrthoDBi
684563at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C8I6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR024788 Malectin-like_Carb-bd_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 1 hit
PF12819 Malectin_like, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9C8I6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFSSCFLLV LLQIFSALLL CLAQDQSGFI SLDCGSPRET SFREKTTNIT
60 70 80 90 100
YISDANFINT GVGGSIKQGY RTQFQQQTWN LRSFPQGIRN CYTLNLTIGD
110 120 130 140 150
EYLIRANFLH GGYDDKPSTQ FELYLGPNLW STVTTTNETE ASIFEMIHIL
160 170 180 190 200
TTDRLQICLV KTGNATPFIS ALELRKLMNT TYLTRQGSLQ TFIRADVGAT
210 220 230 240 250
VNQGYRYGID VFDRVWTPYN FGNWSQISTN QSVNINNDYQ PPEIAMVTAS
260 270 280 290 300
VPTDPDAAMN ISLVGVERTV QFYVFMHFAE IQELKSNDTR EFNIMYNNKH
310 320 330 340 350
IYGPFRPLNF TTSSVFTPTE VVADANGQYI FSLQRTGNST LPPLLNAMEI
360 370 380 390 400
YSVNLLPQQE TDRKEVDAMM NIKSAYGVNK IDWEGDPCVP LDYKWSGVNC
410 420 430 440 450
TYVDNETPKI ISLDLSTSGL TGEILEFISD LTSLEVLDLS NNSLTGSVPE
460 470 480 490 500
FLANMETLKL INLSGNELNG SIPATLLDKE RRGSITLSIE GNTGLCSSTS
510 520 530 540 550
CATTKKKKKN TVIAPVAASL VSVFLIGAGI VTFLILKRKK RTKLGLNPNS
560 570 580 590 600
GTGTTPLHSR SHHGFEPPVI AKNRKLTYID VVKITNNFER VLGRGGFGVV
610 620 630 640 650
YYGVLNNEPV AVKMLTESTA LGYKQFKAEV ELLLRVHHKD LTCLVGYCEE
660 670 680 690 700
GDKMSLIYEF MANGDLKEHL SGKRGPSILT WEGRLRIAAE SAQGLEYLHN
710 720 730 740 750
GCKPQIVHRD IKTTNILLNE KFQAKLADFG LSRSFPLGTE THVSTIVAGT
760 770 780 790 800
PGYLDPEYYR TNWLTEKSDV FSFGVVLLEL VTNQPVIDMK REKSHIAEWV
810 820 830 840 850
GLMLSRGDIN SIVDPKLQGD FDPNTIWKVV ETAMTCLNPS SSRRPTMTQV
860 870 880 890
VMDLKECLNM EMARNMGSRM TDSTNDSSIE LSMNFTTELN PGAR
Length:894
Mass (Da):99,639
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48F63F845804E27E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83S → N in BAC43425 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
FJ708650 mRNA Translation: ACN59246.1
AC025294 Genomic DNA Translation: AAG50874.1
CP002684 Genomic DNA Translation: AEE32717.1
AK118836 mRNA Translation: BAC43425.2

Protein sequence database of the Protein Information Resource

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PIRi
B96557

NCBI Reference Sequences

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RefSeqi
NP_175591.1, NM_104059.3

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT1G51800.1; AT1G51800.1; AT1G51800

Database of genes from NCBI RefSeq genomes

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GeneIDi
841606

Gramene; a comparative resource for plants

More...
Gramenei
AT1G51800.1; AT1G51800.1; AT1G51800

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT1G51800

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ708650 mRNA Translation: ACN59246.1
AC025294 Genomic DNA Translation: AAG50874.1
CP002684 Genomic DNA Translation: AEE32717.1
AK118836 mRNA Translation: BAC43425.2
PIRiB96557
RefSeqiNP_175591.1, NM_104059.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9C8I6, 39 interactors
STRINGi3702.AT1G51800.1

PTM databases

iPTMnetiQ9C8I6

Proteomic databases

PaxDbiQ9C8I6
PRIDEiQ9C8I6

Genome annotation databases

EnsemblPlantsiAT1G51800.1; AT1G51800.1; AT1G51800
GeneIDi841606
GrameneiAT1G51800.1; AT1G51800.1; AT1G51800
KEGGiath:AT1G51800

Organism-specific databases

AraportiAT1G51800
TAIRilocus:2017557 AT1G51800

Phylogenomic databases

eggNOGiENOG410IID2 Eukaryota
COG0515 LUCA
HOGENOMiHOG000116550
InParanoidiQ9C8I6
OMAiHIYGPFR
OrthoDBi684563at2759
PhylomeDBiQ9C8I6

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9C8I6

Gene expression databases

ExpressionAtlasiQ9C8I6 baseline and differential

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR024788 Malectin-like_Carb-bd_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF12819 Malectin_like, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIOS1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C8I6
Secondary accession number(s): Q7FL10
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: June 1, 2001
Last modified: July 31, 2019
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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