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UniProtKB - Q9C8G5 (CSCLD_ARATH)

Entry version 114 (07 Apr 2021)
Sequence version 1 (01 Jun 2001)
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Protein

CSC1-like protein ERD4

Gene

ERD4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca2+ ions (PubMed:30190597). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ions (PubMed:30190597).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CSC1-like protein ERD4Curated
Alternative name(s):
Hyperosmolality-gated Ca2+ permeable channel 3.11 Publication
Short name:
AtOSCA3.11 Publication
Protein EARLY-RESPONSIVE TO DEHYDRATION STRESS 41 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERD41 Publication
Synonyms:OSCA3.11 Publication
Ordered Locus Names:At1g30360Imported
ORF Names:T4K22.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT1G30360

The Arabidopsis Information Resource

More...TAIRi		locus:2204227, AT1G30360

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Transmembranei574 – 594HelicalSequence analysisAdd BLAST21
Transmembranei616 – 636HelicalSequence analysisAdd BLAST21
Transmembranei640 – 660HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004298111 – 724CSC1-like protein ERD4Add BLAST724

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9C8G5

PRoteomics IDEntifications database

More...PRIDEi		Q9C8G5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		220494

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9C8G5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9C8G5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9C8G5, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		25151, 17 interactors

Protein interaction database and analysis system

More...IntActi		Q9C8G5, 13 interactors

STRING: functional protein association networks

More...STRINGi		3702.AT1G30360.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9C8G5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili241 – 309Sequence analysisAdd BLAST69

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CSC1 (TC 1.A.17) family. [View classification]Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1134, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002458_7_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9C8G5

Identification of Orthologs from Complete Genome Data

More...OMAi		WPAFQTS

Database of Orthologous Groups

More...OrthoDBi		395194at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9C8G5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR003864, RSN1_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9C8G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFGSFLVSL GTSFVIFVIL MLLFTWLSRK SGNAPIYYPN RILKGLEPWE 
        60         70         80         90        100
GTSLTRNPFA WMREALTSSE QDVVNLSGVD TAVHFVFLST VLGIFACSSL 
       110        120        130        140        150
LLLPTLLPLA ATDNNIKNTK NATDTTSKGT FSQLDNLSMA NITKKSSRLW 
       160        170        180        190        200
AFLGAVYWIS LVTYFFLWKA YKHVSSLRAQ ALMSADVKPE QFAILVRDMP 
       210        220        230        240        250
APPDGQTQKE FIDSYFREIY PETFYRSLVA TENSKVNKIW EKLEGYKKKL 
       260        270        280        290        300
ARAEAILAAT NNRPTNKTGF CGLVGKQVDS IEYYTELINE SVAKLETEQK 
       310        320        330        340        350
AVLAEKQQTA AVVFFTTRVA AASAAQSLHC QMVDKWTVTE APEPRQLLWQ 
       360        370        380        390        400
NLNIKLFSRI IRQYFIYFFV AVTILFYMIP IAFVSAITTL KNLQRIIPFI 
       410        420        430        440        450
KPVVEITAIR TVLESFLPQI ALIVFLAMLP KLLLFLSKAE GIPSQSHAIR 
       460        470        480        490        500
AASGKYFYFS VFNVFIGVTL AGTLFNTVKD IAKNPKLDMI INLLATSLPK 
       510        520        530        540        550
SATFFLTYVA LKFFIGYGLE LSRIIPLIIF HLKKKYLCKT EAEVKEAWYP 
       560        570        580        590        600
GDLSYATRVP GDMLILTITF CYSVIAPLIL IFGITYFGLG WLVLRNQALK 
       610        620        630        640        650
VYVPSYESYG RMWPHIHQRI LAALFLFQVV MFGYLGAKTF FYTALVIPLI 
       660        670        680        690        700
ITSLIFGYVC RQKFYGGFEH TALEVACREL KQSPDLEEIF RAYIPHSLSS 
       710        720 
HKPEEHEFKG AMSRYQDFNA IAGV
Length:724
Mass (Da):81,935
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E0D3247BD29C987
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti284Y → C in AAK68752 (PubMed:14593172).Curated1
Sequence conflicti485P → T in AAK68752 (PubMed:14593172).Curated1
Sequence conflicti685D → V in BAB63915 (PubMed:8075396).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KJ920369 mRNA Translation: AIU34626.1
AC025295 Genomic DNA Translation: AAG51102.1
CP002684 Genomic DNA Translation: AEE31209.1
AY035092 mRNA Translation: AAK59597.1
AY042812 mRNA Translation: AAK68752.1
AY063056 mRNA Translation: AAL34230.1
AB039928 mRNA Translation: BAB63915.1
AK221977 mRNA Translation: BAD94517.1

Protein sequence database of the Protein Information Resource

More...PIRi		H86427

NCBI Reference Sequences

More...RefSeqi		NP_564354.1, NM_102773.3

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT1G30360.1; AT1G30360.1; AT1G30360

Database of genes from NCBI RefSeq genomes

More...GeneIDi		839916

Gramene; a comparative resource for plants

More...Gramenei		AT1G30360.1; AT1G30360.1; AT1G30360

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT1G30360

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ920369 mRNA Translation: AIU34626.1
AC025295 Genomic DNA Translation: AAG51102.1
CP002684 Genomic DNA Translation: AEE31209.1
AY035092 mRNA Translation: AAK59597.1
AY042812 mRNA Translation: AAK68752.1
AY063056 mRNA Translation: AAL34230.1
AB039928 mRNA Translation: BAB63915.1
AK221977 mRNA Translation: BAD94517.1
PIRiH86427
RefSeqiNP_564354.1, NM_102773.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Z1Felectron microscopy4.80A/B1-724[»]
SMRiQ9C8G5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi25151, 17 interactors
IntActiQ9C8G5, 13 interactors
STRINGi3702.AT1G30360.1

PTM databases

SwissPalmiQ9C8G5

Proteomic databases

PaxDbiQ9C8G5
PRIDEiQ9C8G5
ProteomicsDBi220494

Genome annotation databases

EnsemblPlantsiAT1G30360.1; AT1G30360.1; AT1G30360
GeneIDi839916
GrameneiAT1G30360.1; AT1G30360.1; AT1G30360
KEGGiath:AT1G30360

Organism-specific databases

AraportiAT1G30360
TAIRilocus:2204227, AT1G30360

Phylogenomic databases

eggNOGiKOG1134, Eukaryota
HOGENOMiCLU_002458_7_1_1
InParanoidiQ9C8G5
OMAiWPAFQTS
OrthoDBi395194at2759
PhylomeDBiQ9C8G5

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9C8G5

Gene expression databases

ExpressionAtlasiQ9C8G5, baseline and differential
GenevisibleiQ9C8G5, AT

Family and domain databases

InterProiView protein in InterPro
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR003864, RSN1_7TM
PfamiView protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSCLD_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C8G5
Secondary accession number(s): A0A097NUQ9
, Q56WQ8, Q94B69, Q94II2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: June 1, 2001
Last modified: April 7, 2021
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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