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UniProtKB - Q9C8G5 (CSCLD_ARATH)
Protein
CSC1-like protein ERD4
Gene
ERD4
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca2+ ions (PubMed:30190597).
Mechanosensitive ion channel that converts mechanical stimuli into a flow of ions (PubMed:30190597).
1 PublicationGO - Molecular functioni
- calcium activated cation channel activity Source: GO_Central
- mRNA binding Source: TAIR
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: CSC1-like protein ERD4CuratedAlternative name(s): Hyperosmolality-gated Ca2+ permeable channel 3.11 Publication Short name: AtOSCA3.11 Publication Protein EARLY-RESPONSIVE TO DEHYDRATION STRESS 41 Publication |
Gene namesi | Name:ERD41 Publication Synonyms:OSCA3.11 Publication Ordered Locus Names:At1g30360Imported ORF Names:T4K22.4Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G30360 |
TAIRi | locus:2204227, AT1G30360 |
Subcellular locationi
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Chloroplast
- chloroplast envelope Source: TAIR
Nucleus
- nucleus Source: TAIR
Plasma Membrane
- plasma membrane Source: TAIR
Vacuole
- plant-type vacuole Source: TAIR
Other locations
- integral component of membrane Source: UniProtKB-KW
- plasmodesma Source: TAIR
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 26 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 364 – 384 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 416 – 436 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 456 – 476 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 510 – 530 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 574 – 594 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 616 – 636 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 640 – 660 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000429811 | 1 – 724 | CSC1-like protein ERD4Add BLAST | 724 |
Proteomic databases
PaxDbi | Q9C8G5 |
PRIDEi | Q9C8G5 |
ProteomicsDBi | 220494 |
PTM databases
SwissPalmi | Q9C8G5 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9C8G5, baseline and differential |
Genevisiblei | Q9C8G5, AT |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 25151, 17 interactors |
IntActi | Q9C8G5, 13 interactors |
STRINGi | 3702.AT1G30360.1 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 241 – 309 | Sequence analysisAdd BLAST | 69 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1134, Eukaryota |
HOGENOMi | CLU_002458_7_1_1 |
InParanoidi | Q9C8G5 |
OMAi | NLGLVWP |
OrthoDBi | 395194at2759 |
PhylomeDBi | Q9C8G5 |
Family and domain databases
InterProi | View protein in InterPro IPR045122, Csc1-like IPR032880, Csc1_N IPR027815, PHM7_cyt IPR003864, RSN1_7TM |
PANTHERi | PTHR13018, PTHR13018, 1 hit |
Pfami | View protein in Pfam PF14703, PHM7_cyt, 1 hit PF02714, RSN1_7TM, 1 hit PF13967, RSN1_TM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9C8G5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEFGSFLVSL GTSFVIFVIL MLLFTWLSRK SGNAPIYYPN RILKGLEPWE
60 70 80 90 100
GTSLTRNPFA WMREALTSSE QDVVNLSGVD TAVHFVFLST VLGIFACSSL
110 120 130 140 150
LLLPTLLPLA ATDNNIKNTK NATDTTSKGT FSQLDNLSMA NITKKSSRLW
160 170 180 190 200
AFLGAVYWIS LVTYFFLWKA YKHVSSLRAQ ALMSADVKPE QFAILVRDMP
210 220 230 240 250
APPDGQTQKE FIDSYFREIY PETFYRSLVA TENSKVNKIW EKLEGYKKKL
260 270 280 290 300
ARAEAILAAT NNRPTNKTGF CGLVGKQVDS IEYYTELINE SVAKLETEQK
310 320 330 340 350
AVLAEKQQTA AVVFFTTRVA AASAAQSLHC QMVDKWTVTE APEPRQLLWQ
360 370 380 390 400
NLNIKLFSRI IRQYFIYFFV AVTILFYMIP IAFVSAITTL KNLQRIIPFI
410 420 430 440 450
KPVVEITAIR TVLESFLPQI ALIVFLAMLP KLLLFLSKAE GIPSQSHAIR
460 470 480 490 500
AASGKYFYFS VFNVFIGVTL AGTLFNTVKD IAKNPKLDMI INLLATSLPK
510 520 530 540 550
SATFFLTYVA LKFFIGYGLE LSRIIPLIIF HLKKKYLCKT EAEVKEAWYP
560 570 580 590 600
GDLSYATRVP GDMLILTITF CYSVIAPLIL IFGITYFGLG WLVLRNQALK
610 620 630 640 650
VYVPSYESYG RMWPHIHQRI LAALFLFQVV MFGYLGAKTF FYTALVIPLI
660 670 680 690 700
ITSLIFGYVC RQKFYGGFEH TALEVACREL KQSPDLEEIF RAYIPHSLSS
710 720
HKPEEHEFKG AMSRYQDFNA IAGV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 284 | Y → C in AAK68752 (PubMed:14593172).Curated | 1 | |
Sequence conflicti | 485 | P → T in AAK68752 (PubMed:14593172).Curated | 1 | |
Sequence conflicti | 685 | D → V in BAB63915 (PubMed:8075396).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ920369 mRNA Translation: AIU34626.1 AC025295 Genomic DNA Translation: AAG51102.1 CP002684 Genomic DNA Translation: AEE31209.1 AY035092 mRNA Translation: AAK59597.1 AY042812 mRNA Translation: AAK68752.1 AY063056 mRNA Translation: AAL34230.1 AB039928 mRNA Translation: BAB63915.1 AK221977 mRNA Translation: BAD94517.1 |
PIRi | H86427 |
RefSeqi | NP_564354.1, NM_102773.3 |
Genome annotation databases
EnsemblPlantsi | AT1G30360.1; AT1G30360.1; AT1G30360 |
GeneIDi | 839916 |
Gramenei | AT1G30360.1; AT1G30360.1; AT1G30360 |
KEGGi | ath:AT1G30360 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ920369 mRNA Translation: AIU34626.1 AC025295 Genomic DNA Translation: AAG51102.1 CP002684 Genomic DNA Translation: AEE31209.1 AY035092 mRNA Translation: AAK59597.1 AY042812 mRNA Translation: AAK68752.1 AY063056 mRNA Translation: AAL34230.1 AB039928 mRNA Translation: BAB63915.1 AK221977 mRNA Translation: BAD94517.1 |
PIRi | H86427 |
RefSeqi | NP_564354.1, NM_102773.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5Z1F | electron microscopy | 4.80 | A/B | 1-724 | [»] | |
SMRi | Q9C8G5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 25151, 17 interactors |
IntActi | Q9C8G5, 13 interactors |
STRINGi | 3702.AT1G30360.1 |
PTM databases
SwissPalmi | Q9C8G5 |
Proteomic databases
PaxDbi | Q9C8G5 |
PRIDEi | Q9C8G5 |
ProteomicsDBi | 220494 |
Genome annotation databases
EnsemblPlantsi | AT1G30360.1; AT1G30360.1; AT1G30360 |
GeneIDi | 839916 |
Gramenei | AT1G30360.1; AT1G30360.1; AT1G30360 |
KEGGi | ath:AT1G30360 |
Organism-specific databases
Araporti | AT1G30360 |
TAIRi | locus:2204227, AT1G30360 |
Phylogenomic databases
eggNOGi | KOG1134, Eukaryota |
HOGENOMi | CLU_002458_7_1_1 |
InParanoidi | Q9C8G5 |
OMAi | NLGLVWP |
OrthoDBi | 395194at2759 |
PhylomeDBi | Q9C8G5 |
Miscellaneous databases
PROi | PR:Q9C8G5 |
Gene expression databases
ExpressionAtlasi | Q9C8G5, baseline and differential |
Genevisiblei | Q9C8G5, AT |
Family and domain databases
InterProi | View protein in InterPro IPR045122, Csc1-like IPR032880, Csc1_N IPR027815, PHM7_cyt IPR003864, RSN1_7TM |
PANTHERi | PTHR13018, PTHR13018, 1 hit |
Pfami | View protein in Pfam PF14703, PHM7_cyt, 1 hit PF02714, RSN1_7TM, 1 hit PF13967, RSN1_TM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CSCLD_ARATH | |
Accessioni | Q9C8G5Primary (citable) accession number: Q9C8G5 Secondary accession number(s): A0A097NUQ9 Q94II2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 9, 2014 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families