UniProtKB - Q9C882 (GTL1_ARATH)
Protein
Trihelix transcription factor GTL1
Gene
GTL1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Transcription repressor that binds specific DNA sequence such as GT3 box 5'-GGTAAA-3' in the SDD1 promoter (PubMed:21169508). Negative regulator of water use efficiency (WUE) via the promotion of stomatal density and distribution by the transcription repression of SDD1 (PubMed:21169508). Regulates the expression of several cell cycle genes and endoreduplication, especially in trichomes where it prevents ploidy-dependent plant cell growth (PubMed:19717615). Regulates negatively root hair growth by directly binding RSL4 promoter and repressing RSL4 expression (PubMed:29439132).3 Publications
Miscellaneous
Plants overexpressing GTL1 fail to develop root hairs.1 Publication
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity Source: TAIR
- sequence-specific DNA binding Source: TAIR
GO - Biological processi
- cellular response to water deprivation Source: UniProtKB
- negative regulation of cell growth Source: TAIR
- negative regulation of DNA endoreduplication Source: TAIR
- negative regulation of transcription, DNA-templated Source: UniProtKB
- regulation of cell size Source: TAIR
- regulation of stomatal complex development Source: TAIR
- regulation of stomatal complex patterning Source: UniProtKB
- response to water deprivation Source: TAIR
- transcription, DNA-templated Source: TAIR
- trichome morphogenesis Source: TAIR
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Trihelix transcription factor GTL11 PublicationAlternative name(s): GT2-LIKE protein 11 Publication Short name: AtGTL11 Publication Short name: Protein GT-2-LIKE11 Publication Trihelix DNA-binding protein GTL1Curated |
Gene namesi | Name:GTL11 Publication Ordered Locus Names:At1g33240Imported ORF Names:T16O9.10Imported, T9L6.10Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G33240 |
TAIRi | locus:2196663, AT1G33240 |
Subcellular locationi
Nucleus
- Nucleus 3 Publications
Note: Present within the nucleus during the postbranching stages of trichome development.1 Publication
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Increased water deficit tolerance and higher integrated water use efficiency (WUE) by reducing daytime transpiration associated with a higher expression of SDD1 (PubMed:21169508). Increased trichome cell size with normal patterning and branching accompanied with an increase in the nuclear DNA content only in trichomes that have completed branching (PubMed:19717615). No visible phenotype under normal growth conditions, but the double mutant seedlings gtl1-1 and df1-1 exhibit increased root hair length (PubMed:29439132).3 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000405798 | 1 – 587 | Trihelix transcription factor GTL1Add BLAST | 587 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 3 (identifier: Q9C882-3) | |||||
Modified residuei | 650 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9C882 |
PRIDEi | Q9C882 |
ProteomicsDBi | 247201 [Q9C882-1] |
PTM databases
iPTMneti | Q9C882 |
Expressioni
Tissue specificityi
Mostly expressed in siliques, and, to a lower extent, in growing root hairs, leaves, stems, and flowers (PubMed:9501260). Present in abaxial epidermal cells, predominantly in guard cells, pavement cells, and meristemoids (PubMed:21169508).2 Publications
Inductioni
Down-regulated by water stress.1 Publication
Gene expression databases
ExpressionAtlasi | Q9C882, baseline and differential |
Genevisiblei | Q9C882, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 25452, 11 interactors |
IntActi | Q9C882, 9 interactors |
STRINGi | 3702.AT1G33240.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 119 | Myb-like 1PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 434 – 492 | Myb-like 2PROSITE-ProRule annotationAdd BLAST | 59 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 285 – 328 | Sequence analysisAdd BLAST | 44 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 96 – 103 | Nuclear localization signal 1By similarity | 8 | |
Motifi | 472 – 479 | Nuclear localization signal 2By similarity | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 41 – 53 | Gly-richAdd BLAST | 13 | |
Compositional biasi | 151 – 213 | Pro-richAdd BLAST | 63 | |
Compositional biasi | 234 – 243 | Poly-Asp | 10 | |
Compositional biasi | 350 – 409 | Pro-richAdd BLAST | 60 | |
Compositional biasi | 380 – 419 | Gln-richAdd BLAST | 40 |
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG4282, Eukaryota |
HOGENOMi | CLU_013796_1_0_1 |
InParanoidi | Q9C882 |
OMAi | DEIWREP |
OrthoDBi | 782634at2759 |
PhylomeDBi | Q9C882 |
Family and domain databases
InterProi | View protein in InterPro IPR017877, Myb-like_dom IPR001005, SANT/Myb |
SMARTi | View protein in SMART SM00717, SANT, 2 hits |
PROSITEi | View protein in PROSITE PS50090, MYB_LIKE, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketNote: A number of isoforms are produced. According to EST sequences.
This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9C882-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEQGGGGGGN EVVEEASPIS SRPPANNLEE LMRFSAAADD GGLGGGGGGG
60 70 80 90 100
GGGSASSSSG NRWPREETLA LLRIRSDMDS TFRDATLKAP LWEHVSRKLL
110 120 130 140 150
ELGYKRSSKK CKEKFENVQK YYKRTKETRG GRHDGKAYKF FSQLEALNTT
160 170 180 190 200
PPSSSLDVTP LSVANPILMP SSSSSPFPVF SQPQPQTQTQ PPQTHNVSFT
210 220 230 240 250
PTPPPLPLPS MGPIFTGVTF SSHSSSTASG MGSDDDDDDM DVDQANIAGS
260 270 280 290 300
SSRKRKRGNR GGGGKMMELF EGLVRQVMQK QAAMQRSFLE ALEKREQERL
310 320 330 340 350
DREEAWKRQE MARLAREHEV MSQERAASAS RDAAIISLIQ KITGHTIQLP
360 370 380 390 400
PSLSSQPPPP YQPPPAVTKR VAEPPLSTAQ SQSQQPIMAI PQQQILPPPP
410 420 430 440 450
PSHPHAHQPE QKQQQQPQQE MVMSSEQSSL PSSSRWPKAE ILALINLRSG
460 470 480 490 500
MEPRYQDNVP KGLLWEEIST SMKRMGYNRN AKRCKEKWEN INKYYKKVKE
510 520 530 540 550
SNKKRPQDAK TCPYFHRLDL LYRNKVLGSG GGSSTSGLPQ DQKQSPVTAM
560 570 580
KPPQEGLVNV QQTHGSASTE EEEPIEESPQ GTEKKTL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8ATX4 | A0A1P8ATX4_ARATH | GT-2-like 1 | GTL1 AT-GTL1, AT-GTL2, ATGTL1, GT-2-like 1, GT2-LIKE 1 | 630 | Annotation score: | ||
A0A1P8ATZ4 | A0A1P8ATZ4_ARATH | GT-2-like 1 | GTL1 AT-GTL1, AT-GTL2, ATGTL1, GT-2-like 1, GT2-LIKE 1 | 594 | Annotation score: |
Sequence cautioni
The sequence AAF97353 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG51283 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA05995 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | A → V in CAA05995 (PubMed:9501260).Curated | 1 | |
Sequence conflicti | 70 | A → V in CAA05996 (PubMed:9501260).Curated | 1 | |
Sequence conflicti | 70 | A → V in CAA05998 (PubMed:9501260).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040713 | 151 – 399 | Missing in isoform 2. 1 PublicationAdd BLAST | 249 | |
Alternative sequenceiVSP_040714 | 585 – 587 | KTL → PEDLVMRELIQQQQQLQQQE SMIGEYEKIEESHNYNNMEE EEDQEMDEEELDEDEKSAAF EIAFQSPANRGGNGHTEPPF LTMVQ in isoform 3. Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ003215 Genomic DNA Translation: CAA05995.1 Sequence problems. AJ003216 Genomic DNA Translation: CAA05996.1 Sequence problems. AJ003218 mRNA Translation: CAA05998.1 AC021045 Genomic DNA Translation: AAF97353.1 Sequence problems. AC027035 Genomic DNA Translation: AAG51283.1 Sequence problems. CP002684 Genomic DNA Translation: AEE31573.1 AY140085 mRNA Translation: AAM98226.1 BT008824 mRNA Translation: AAP68263.1 |
PIRi | B86456 |
RefSeqi | NP_001322396.1, NM_001333032.1 NP_174594.1, NM_103052.4 [Q9C882-3] |
Genome annotation databases
EnsemblPlantsi | AT1G33240.1; AT1G33240.1; AT1G33240 [Q9C882-3] AT1G33240.3; AT1G33240.3; AT1G33240 |
GeneIDi | 840218 |
Gramenei | AT1G33240.1; AT1G33240.1; AT1G33240 [Q9C882-3] AT1G33240.3; AT1G33240.3; AT1G33240 |
KEGGi | ath:AT1G33240 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ003215 Genomic DNA Translation: CAA05995.1 Sequence problems. AJ003216 Genomic DNA Translation: CAA05996.1 Sequence problems. AJ003218 mRNA Translation: CAA05998.1 AC021045 Genomic DNA Translation: AAF97353.1 Sequence problems. AC027035 Genomic DNA Translation: AAG51283.1 Sequence problems. CP002684 Genomic DNA Translation: AEE31573.1 AY140085 mRNA Translation: AAM98226.1 BT008824 mRNA Translation: AAP68263.1 |
PIRi | B86456 |
RefSeqi | NP_001322396.1, NM_001333032.1 NP_174594.1, NM_103052.4 [Q9C882-3] |
3D structure databases
SMRi | Q9C882 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 25452, 11 interactors |
IntActi | Q9C882, 9 interactors |
STRINGi | 3702.AT1G33240.1 |
PTM databases
iPTMneti | Q9C882 |
Proteomic databases
PaxDbi | Q9C882 |
PRIDEi | Q9C882 |
ProteomicsDBi | 247201 [Q9C882-1] |
Genome annotation databases
EnsemblPlantsi | AT1G33240.1; AT1G33240.1; AT1G33240 [Q9C882-3] AT1G33240.3; AT1G33240.3; AT1G33240 |
GeneIDi | 840218 |
Gramenei | AT1G33240.1; AT1G33240.1; AT1G33240 [Q9C882-3] AT1G33240.3; AT1G33240.3; AT1G33240 |
KEGGi | ath:AT1G33240 |
Organism-specific databases
Araporti | AT1G33240 |
TAIRi | locus:2196663, AT1G33240 |
Phylogenomic databases
eggNOGi | KOG4282, Eukaryota |
HOGENOMi | CLU_013796_1_0_1 |
InParanoidi | Q9C882 |
OMAi | DEIWREP |
OrthoDBi | 782634at2759 |
PhylomeDBi | Q9C882 |
Miscellaneous databases
PROi | PR:Q9C882 |
Gene expression databases
ExpressionAtlasi | Q9C882, baseline and differential |
Genevisiblei | Q9C882, AT |
Family and domain databases
InterProi | View protein in InterPro IPR017877, Myb-like_dom IPR001005, SANT/Myb |
SMARTi | View protein in SMART SM00717, SANT, 2 hits |
PROSITEi | View protein in PROSITE PS50090, MYB_LIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GTL1_ARATH | |
Accessioni | Q9C882Primary (citable) accession number: Q9C882 Secondary accession number(s): O48590 Q9LP25 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | April 7, 2021 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names