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Protein

Tyrosine-sulfated glycopeptide receptor 1

Gene

PSY1R

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine-sulfated glycopeptide receptor with a serine/threonine-protein kinase activity (PubMed:17989228, PubMed:25267325). Regulates, in response to tyrosine-sulfated glycopeptide binding, a signaling cascade involved in cellular proliferation and plant growth (PubMed:17989228). Not involved in PSK perception (PubMed:17989228). Involved in plant immunity, with antagonistic effects on bacterial and fungal resistances (PubMed:23062058). Mediates activation of the plasma membrane H+-ATPase by PSY1 (PubMed:25267325). Phosphorylates AHA2 at Thr-881 (PubMed:25267325).3 Publications

Miscellaneous

PSYR1 and PSKR1 mediate a signaling pathway by two distinct ligands, which redundantly contribute to cellular proliferation and plant growth.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei831ATPPROSITE-ProRule annotation1
Active sitei929Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi809 – 817ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • peptide receptor activity Source: TAIR
  • protein serine/threonine kinase activity Source: TAIR
  • transmembrane signaling receptor activity Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-sulfated glycopeptide receptor 1Curated (EC:2.7.11.1Curated)
Alternative name(s):
PSY1 receptor1 Publication
Gene namesi
Name:PSY1R1 Publication
Synonyms:PSYR1Curated
Ordered Locus Names:At1g72300Imported
ORF Names:T9N14.20Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G72300
TAIRilocus:2207056 AT1G72300

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei721 – 741HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Loss of sensitivity to PSY1 (PubMed:17989228). Loss of PSY1 induced phosphorylation of AHA2 and reduced hypocotyl elongation (PubMed:25267325). Increased symptom formation, disease index, lesion size and fungal growth after infection with A.brassicicola, but increased resistance to bacterial infection (PubMed:23062058).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1072 – 1095Missing : Loss of kinase activity and loss of interaction with AHA1 and AHA2. 1 PublicationAdd BLAST24

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003656191 – 1095Tyrosine-sulfated glycopeptide receptor 1Add BLAST1095

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi569N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi592N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi616N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi662N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi714N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei792PhosphothreonineBy similarity1
Modified residuei800PhosphothreonineBy similarity1
Modified residuei876PhosphotyrosineBy similarity1
Modified residuei916PhosphotyrosineBy similarity1
Modified residuei971PhosphotyrosineBy similarity1

Post-translational modificationi

Autophosphorylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9C7S5
PRIDEiQ9C7S5

Expressioni

Tissue specificityi

Expressed ubiquitously, including in the shoot apical meristem and in the elongation zone of the root meristem.1 Publication

Gene expression databases

ExpressionAtlasiQ9C7S5 baseline and differential
GenevisibleiQ9C7S5 AT

Interactioni

Subunit structurei

Homo- and heterodimers with PSKR1. Interacts (via C-terminus) with AHA1 and AHA2 (via the R-domain).1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi28782, 28 interactors
IntActiQ9C7S5, 34 interactors
STRINGi3702.AT1G72300.1

Structurei

3D structure databases

ProteinModelPortaliQ9C7S5
SMRiQ9C7S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati91 – 115LRR 1Add BLAST25
Repeati116 – 139LRR 2Add BLAST24
Repeati141 – 165LRR 3Add BLAST25
Repeati170 – 195LRR 4Add BLAST26
Repeati197 – 221LRR 5Add BLAST25
Repeati223 – 246LRR 6Add BLAST24
Repeati247 – 270LRR 7Add BLAST24
Repeati271 – 294LRR 8Add BLAST24
Repeati295 – 318LRR 9Add BLAST24
Repeati320 – 342LRR 10Add BLAST23
Repeati344 – 366LRR 11Add BLAST23
Repeati367 – 391LRR 12Add BLAST25
Repeati393 – 415LRR 13Add BLAST23
Repeati416 – 439LRR 14Add BLAST24
Repeati441 – 466LRR 15Add BLAST26
Repeati470 – 494LRR 16Add BLAST25
Repeati495 – 517LRR 17Add BLAST23
Repeati518 – 542LRR 18Add BLAST25
Repeati566 – 589LRR 19Add BLAST24
Repeati604 – 628LRR 20Add BLAST25
Repeati629 – 652LRR 21Add BLAST24
Repeati654 – 677LRR 22Add BLAST24
Domaini803 – 1074Protein kinasePROSITE-ProRule annotationAdd BLAST272

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1087 – 1094Poly-Glu8

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPZ3 Eukaryota
COG0515 LUCA
COG4886 LUCA
HOGENOMiHOG000116551
InParanoidiQ9C7S5
OMAiHNREDET
OrthoDBiEOG093601TF
PhylomeDBiQ9C7S5

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR013210 LRR_N_plant-typ
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF08263 LRRNT_2, 1 hit
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 12 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C7S5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIDEKMRSKS IGPFVRQVKP LSPHMVLFVL LYVLSISVFF LTVSEAVCNL
60 70 80 90 100
QDRDSLLWFS GNVSSPVSPL HWNSSIDCCS WEGISCDKSP ENRVTSIILS
110 120 130 140 150
SRGLSGNLPS SVLDLQRLSR LDLSHNRLSG PLPPGFLSAL DQLLVLDLSY
160 170 180 190 200
NSFKGELPLQ QSFGNGSNGI FPIQTVDLSS NLLEGEILSS SVFLQGAFNL
210 220 230 240 250
TSFNVSNNSF TGSIPSFMCT ASPQLTKLDF SYNDFSGDLS QELSRCSRLS
260 270 280 290 300
VLRAGFNNLS GEIPKEIYNL PELEQLFLPV NRLSGKIDNG ITRLTKLTLL
310 320 330 340 350
ELYSNHIEGE IPKDIGKLSK LSSLQLHVNN LMGSIPVSLA NCTKLVKLNL
360 370 380 390 400
RVNQLGGTLS AIDFSRFQSL SILDLGNNSF TGEFPSTVYS CKMMTAMRFA
410 420 430 440 450
GNKLTGQISP QVLELESLSF FTFSDNKMTN LTGALSILQG CKKLSTLIMA
460 470 480 490 500
KNFYDETVPS NKDFLRSDGF PSLQIFGIGA CRLTGEIPAW LIKLQRVEVM
510 520 530 540 550
DLSMNRFVGT IPGWLGTLPD LFYLDLSDNF LTGELPKELF QLRALMSQKA
560 570 580 590 600
YDATERNYLE LPVFVNPNNV TTNQQYNQLS SLPPTIYIKR NNLTGTIPVE
610 620 630 640 650
VGQLKVLHIL ELLGNNFSGS IPDELSNLTN LERLDLSNNN LSGRIPWSLT
660 670 680 690 700
GLHFLSYFNV ANNTLSGPIP TGTQFDTFPK ANFEGNPLLC GGVLLTSCDP
710 720 730 740 750
TQHSTTKMGK GKVNRTLVLG LVLGLFFGVS LILVLLALLV LSKRRVNPGD
760 770 780 790 800
SENAELEINS NGSYSEVPPG SDKDISLVLL FGNSRYEVKD LTIFELLKAT
810 820 830 840 850
DNFSQANIIG CGGFGLVYKA TLDNGTKLAV KKLTGDYGMM EKEFKAEVEV
860 870 880 890 900
LSRAKHENLV ALQGYCVHDS ARILIYSFME NGSLDYWLHE NPEGPAQLDW
910 920 930 940 950
PKRLNIMRGA SSGLAYMHQI CEPHIVHRDI KSSNILLDGN FKAYVADFGL
960 970 980 990 1000
SRLILPYRTH VTTELVGTLG YIPPEYGQAW VATLRGDVYS FGVVMLELLT
1010 1020 1030 1040 1050
GKRPMEVFRP KMSRELVAWV HTMKRDGKPE EVFDTLLRES GNEEAMLRVL
1060 1070 1080 1090
DIACMCVNQN PMKRPNIQQV VDWLKNIEAE KNQNNREEPE EEEET
Length:1,095
Mass (Da):121,521
Last modified:June 1, 2001 - v1
Checksum:i52DECA8C2E0669BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067754 Genomic DNA Translation: AAG51803.1
CP002684 Genomic DNA Translation: AEE35300.1
AY080797 mRNA Translation: AAL87278.1
AY133783 mRNA Translation: AAM91717.1
AK229165 mRNA Translation: BAF01036.1
PIRiG96746
RefSeqiNP_177374.1, NM_105889.6
UniGeneiAt.35115

Genome annotation databases

EnsemblPlantsiAT1G72300.1; AT1G72300.1; AT1G72300
GeneIDi843562
GrameneiAT1G72300.1; AT1G72300.1; AT1G72300
KEGGiath:AT1G72300

Similar proteinsi

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067754 Genomic DNA Translation: AAG51803.1
CP002684 Genomic DNA Translation: AEE35300.1
AY080797 mRNA Translation: AAL87278.1
AY133783 mRNA Translation: AAM91717.1
AK229165 mRNA Translation: BAF01036.1
PIRiG96746
RefSeqiNP_177374.1, NM_105889.6
UniGeneiAt.35115

3D structure databases

ProteinModelPortaliQ9C7S5
SMRiQ9C7S5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28782, 28 interactors
IntActiQ9C7S5, 34 interactors
STRINGi3702.AT1G72300.1

Proteomic databases

PaxDbiQ9C7S5
PRIDEiQ9C7S5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G72300.1; AT1G72300.1; AT1G72300
GeneIDi843562
GrameneiAT1G72300.1; AT1G72300.1; AT1G72300
KEGGiath:AT1G72300

Organism-specific databases

AraportiAT1G72300
TAIRilocus:2207056 AT1G72300

Phylogenomic databases

eggNOGiENOG410IPZ3 Eukaryota
COG0515 LUCA
COG4886 LUCA
HOGENOMiHOG000116551
InParanoidiQ9C7S5
OMAiHNREDET
OrthoDBiEOG093601TF
PhylomeDBiQ9C7S5

Miscellaneous databases

PROiPR:Q9C7S5

Gene expression databases

ExpressionAtlasiQ9C7S5 baseline and differential
GenevisibleiQ9C7S5 AT

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR013210 LRR_N_plant-typ
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF08263 LRRNT_2, 1 hit
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 12 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSYR1_ARATH
AccessioniPrimary (citable) accession number: Q9C7S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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