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Entry version 146 (02 Jun 2021)
Sequence version 2 (02 May 2006)
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Protein

Histone H3-lysine(4) N-trimethyltransferase ATX1

Gene

ATX1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the promoter and regulates the transcription of target genes, maintaining them in an active state; at promoters, required for TATA binding proteins (TBPs, e.g. TBP1 and TBP2) and RNA polymerase II (Pol II) recruitment, and, in a subsequent event, is recruited by a phosphorylated form of Pol II to the +300-bp region of transcribed sequences to trimethylates nucleosomes (PubMed:21266657, PubMed:23284292).

Histone trimethyltransferase that trimethylates 'Lys-4' of histone H3 (H3K4me3); H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation and is required for efficient elongation of transcription but not for transcription initiation (PubMed:17965588, PubMed:17881378, PubMed:18375658, PubMed:23284292).

Methylates only a limited fraction of nucleosomes of target genes (e.g. FLC, NAP, XTH33 and WRKY70) (PubMed:18375658).

Necessary for WDR5A occupancy at WRKY70 and LTP7 genes (PubMed:23284292).

Required to maintain the active state of class A (AP1 and AP2), class B (PI and AP3) and class C (AG, AGAMOUS) floral homeotic genes at early stages of flower development (PubMed:17881378).

Together with CLF, modulates AG nucleosome methylation statement (PubMed:17881378).

Involved in epigenetic regulation (e.g. H3K4me3) of the floral repressors FLC, FT and SOC1 to prevent the transition from vegetative to reproductive development, independently of the photoperiod; binds the active FLC locus before flowering, but this interaction is released upon the transition to flowering (PubMed:18375656, PubMed:24102415, PubMed:30150325).

Regulates floral organ identity and flowering transition. Functions as a receptor for the lipid messenger phosphatidylinositol 5-phosphate (PI5P), which regulates negatively its transcriptional activation activity. Exhibits histone methylase activity and subsequent transcriptional regulation on WRKY70 gene, and, to a lower extent on secondary defense-response targets salicylic acid (SA)-responsive gene PR1 and jasmonic acid (JA)-responsive gene THI2.1 (PubMed:17965588).

Involved in response to dehydration stress-response in both abscisic acid (ABA)-dependent and ABA-independent pathways; this includes specific genes (e.g. COR15A, ADH1, CBF4, RD29A, RD29B, RD26, ABF3, NCED3 and ABA3) epigenetic regulation (e.g. H3K4me3 and Pol II recruitment) to promotes their transcription and influence ABA production (PubMed:19901554, PubMed:21309869).

Implicated in stomatal closure regulation (PubMed:21309869).

Indirect repressor of XTH genes (XTH33) (PubMed:19154201).

Necessary for the phosphorylation of Pol II NRPB1 (e.g. Ser5P and Ser2P) at the promoters of target genes, thus regulating both early and late stages of transcription (PubMed:21266657).

Controls root growth and architecture by regulating the timing of root development, stem cell niche maintenance (e.g. quiescent center (QC)), and cell patterning during primary and lateral root development (PubMed:25205583).

Modulates cell cycle duration, cell production, and the transition from cell proliferation in the root apical meristem (RAM) to cell elongation (PubMed:25205583).

14 Publications

Trimethylates A4/EF1A post-translationally at Lys-396 (PubMed:21245040).

Required for actin cytoskeleton organization (PubMed:21245040).

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei908S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei954S-adenosyl-L-methioninePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi980ZincBy similarity1
Metal bindingi1026ZincBy similarity1
Metal bindingi1028ZincBy similarity1
Metal bindingi1033ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri591 – 647Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri609 – 660PHD-type 1PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri665 – 698C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri722 – 785PHD-type 2PROSITE-ProRule annotationAdd BLAST64

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
Biological processAbscisic acid signaling pathway, Stress response, Transcription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H3-lysine(4) N-trimethyltransferase ATX11 Publication (EC:2.1.1.3543 Publications)
Alternative name(s):
Protein SET DOMAIN GROUP 271 Publication
Protein-lysine N-trimethyltransferase ATX1-SoloSET1 Publication (EC:2.1.1.-1 Publication)
Trithorax-homolog protein 11 Publication
Short name:
TRX-homolog protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATX11 Publication
Synonyms:SDG271 Publication, SET271 Publication, TRX11 Publication
Ordered Locus Names:At2g31650Imported
ORF Names:T9H9.17Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT2G31650

The Arabidopsis Information Resource

More...
TAIRi
locus:2065923, AT2G31650

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Decreased germination rates, larger stomatal apertures, more rapid transpiration and decreased tolerance to dehydration stress in atx1 plants partly due to reduced ABA biosynthesis as a result of decreased NCED3 transcript levels (PubMed:21309869). Reduced trimethylated 'Lys-4' histone H3 (H3K4me3) but normal dimethylated 'Lys-4' histone H3 (H3K4me2) at NAP, XTH33, NCED3, LTP and WRKY70 nucleosomes leading to decreased transcript levels in atx1 plants (PubMed:18375658, PubMed:21266657). Lower Pol II phosphorylation (e.g. Ser5P and Ser2P) and TBP (e.g. TBP1 and TBP2) occupancy at the promoters of NCED3, LTP and WRKY70 associated with reduced gene expression (PubMed:21266657). Strongly reduced occupancy of WDR5A at WRKY70 and LTP7 genes (PubMed:23284292). Accelerated transition from vegetative to reproductive development, under both long-day and short-day conditions, especially in medium-day conditions (12 hours light / 12 hours dark), due to FLC, FT and SOC1 epigenetic misregulation; specific depletion in H3K4me3 but increased H3K27me2 associated with reduced FLC, FT and SOC1 levels (PubMed:18375656, PubMed:21245040, PubMed:24102415). Misexpression of AGAMOUS, recognizable phenotypes (e.g. small and slightly serrated leaves, and early flowering time) and loss of H3K4me3 histone H3-tail marks (PubMed:17881378). Impaired in primary root growth with irregular shape and expanded quiescent center (QC) cells (PubMed:25205583). Ectopic expression of QC-specific markers (e.g. QC46, WOX5 and SCR) in the primary RAM and in the developing lateral root primordia (PubMed:25205583). Lack of coordination between cell division and cell growth leading to atypical distribution of T-divisions, the presence of oblique divisions, and abnormal cell patterning in the root apical meristem (RAM) (PubMed:25205583). Reduced lateral root (LR) density within the branching zone (PubMed:25205583). Altered transcription levels of target genes, including several endomembrane and cell wall-associated proteins coding genes, XTH genes being up-regulated (PubMed:18375658, PubMed:19154201). Derepression of XTH33 in roots, stems and seedlings (PubMed:19154201). Increased sensitivity to osmotic or dehydration stress due to an altered expression of genes involved in response to drought in both abscisic acid (ABA)-dependent and ABA-independent pathways (e.g. COR15A, ADH1, CBF4, RD29A, RD29B, RD26, ABF3, NCED3 and ABA3) (PubMed:19901554, PubMed:21309869). Double mutant plants atx1 clf exhibits normal leaf-phenotype and flowering time (PubMed:17881378). Reduced basal levels and induction of WRKY70 and of the salicylic acid (SA)-responsive gene PR1 upon pathogen infection by Pseudomonas syringae DC3000 or after SA treatment, but increased basal levels of the jasmonic acid (JA)-responsive gene THI2.1or after JA treatment (PubMed:17965588).12 Publications
Precocious flowering, asymmetric rosettes, aberrant flowers and chlorosis (PubMed:21245040). Dramatically different pattern of reduced actin bundles and absent actin transvacuolar cytoplasmic strands (TVSs) (PubMed:21245040).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi927Y → A: Deficient methyltransferase catalytic activity associated with early-flowering phenotype and reduced WRKY 70 and LTP7 transcripts levels but normal recruitment of WDR5A at target genes but without histone modification; when associated with A-945, A-954, A-1013 and A-1015. 1 Publication1
Mutagenesisi945Y → A: Deficient methyltransferase catalytic activity associated with early-flowering phenotype and reduced WRKY 70 and LTP7 transcripts levels but normal recruitment of WDR5A at target genes but without histone modification; when associated with A-927, A-954, A-1013 and A-1015. 1 Publication1
Mutagenesisi947S → A: Repressed FLC transcription activation associated with reduced activation by SEC-mediated O-GlcNAcylation and lower methyltransferase catalytic activity. 1 Publication1
Mutagenesisi954Y → A: Deficient methyltransferase catalytic activity associated with early-flowering phenotype and reduced WRKY 70 and LTP7 transcripts levels but normal recruitment of WDR5A at target genes but without histone modification; when associated with A-927, A-945, A-1013 and A-1015. 1 Publication1
Mutagenesisi1013Y → A: Deficient methyltransferase catalytic activity associated with early-flowering phenotype and reduced WRKY 70 and LTP7 transcripts levels but normal recruitment of WDR5A at target genes but without histone modification; when associated with A-927, A-945, A-954 and A-1015. 1 Publication1
Mutagenesisi1015Y → A: Deficient methyltransferase catalytic activity associated with early-flowering phenotype and reduced WRKY 70 and LTP7 transcripts levels but normal recruitment of WDR5A at target genes but without histone modification; when associated with A-927, A-945, A-954 and A-1013. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002333541 – 1062Histone H3-lysine(4) N-trimethyltransferase ATX1Add BLAST1062

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi947O-linked (GlcNAc) serine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Activated via O-glycosylation by SEC; this modification triggers FLC locus H3K4me3 histone modification, thus preventing premature flowering.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9C5X4

PRoteomics IDEntifications database

More...
PRIDEi
Q9C5X4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
241094 [Q9C5X4-1]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in cotyledons, but weak levels in the first true leaves, except at the hydothodes (PubMed:21245040). Ubiquitous with higher levels in dividing tissues, including inflorescence meristem and flower primordia (PubMed:11418242, PubMed:12699618, PubMed:18375658). Expressed also in leaves (especially at hydathodes), in growing inflorescence stems and in the mature flowers (PubMed:18375658).4 Publications
Strongly expressed in young seedlings.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is associated with the initiation of flower organs and ovules (PubMed:12699618, PubMed:18375658). Accumulates in the tissues of young seedlings but also in adult plants (PubMed:18375658, PubMed:21245040). In flowers, present in sepals, in the vasculature of petals, and in the filaments of the stamens and, at low levels, at the tips of the stigma (PubMed:18375658). In seedlings, observed in the vasculature of the cotyledons, hypocotyls, stems, and the first pair of leaves (PubMed:18375656, PubMed:21245040). Just prior to flowering, a strong reduction in expression levels occurs in the vasculature (PubMed:18375656).4 Publications
Expressed in young seedlings (PubMed:21245040). Later in development, confined to cells at attachment sites of organ to stems (PubMed:21245040).1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9C5X4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C5X4, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PIP5 (PubMed:16585509).

Interacts with WDR5A (PubMed:19567704, PubMed:23284292). Binds to CLF in the nucleus (PubMed:17881378).

Interacts with NRPB1 CTD domain, especially when NRPB1 is phosphorylated on 'Ser-5' of the heptapeptide repeat (PubMed:21266657).

Component of a nuclear protein complex containing at least TATA binding proteins (TBPs, e.g. TBP1 and TBP2) and ATX1 (PubMed:21266657). Associates with ULT1 for trimethylating 'Lys-4' on histone H3 (H3K4me3) at flower MADS box gene loci (PubMed:23632855).

Interacts with SEC (PubMed:30150325).

7 Publications

Interacts with A4/EF1A in the cytoplasm on the nuclear periphery.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
3068, 6 interactors

STRING: functional protein association networks

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STRINGi
3702.AT2G31650.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9C5X4

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini301 – 365PWWPPROSITE-ProRule annotationAdd BLAST65
Domaini441 – 500FYR N-terminalPROSITE-ProRule annotationAdd BLAST60
Domaini504 – 586FYR C-terminalPROSITE-ProRule annotationAdd BLAST83
Domaini898 – 1016SETPROSITE-ProRule annotationAdd BLAST119
Domaini1022 – 1038Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni159 – 184DisorderedSequence analysisAdd BLAST26
Regioni401 – 424DisorderedSequence analysisAdd BLAST24
Regioni599 – 1062Interaction with PIP51 PublicationAdd BLAST464
Regioni977 – 978S-adenosyl-L-methionine bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi404 – 423Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri591 – 647Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri609 – 660PHD-type 1PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri665 – 698C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri722 – 785PHD-type 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1080, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_005729_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9C5X4

Identification of Orthologs from Complete Genome Data

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OMAi
PYIVSGF

Database of Orthologous Groups

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OrthoDBi
181572at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9C5X4

Family and domain databases

Conserved Domains Database

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CDDi
cd15662, ePHD_ATX1_2_like, 1 hit
cd15494, PHD_ATX1_2_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR041956, ATX1/2_ePHD
IPR042010, ATX1/2_PHD
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR019023, Lamin-B_rcpt_of_tudor
IPR002219, PE/DAG-bd
IPR003616, Post-SET_dom
IPR000313, PWWP_dom
IPR001214, SET_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

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Pfami
View protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF09465, LBR_tudor, 1 hit
PF00855, PWWP, 1 hit
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 2 hits
SM00293, PWWP, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50812, PWWP, 1 hit
PS50280, SET, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9C5X4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACFSNETQI EIDVHDLVEA PIRYDSIESI YSIPSSALCC VNAVGSHSLM
60 70 80 90 100
SKKVKAQKLP MIEQFEIEGS GVSASDDCCR SDDYKLRIQR PEIVRVYYRR
110 120 130 140 150
RKRPLRECLL DQAVAVKTES VELDEIDCFE EKKRRKIGNC ELVKSGMESI
160 170 180 190 200
GLRRCKENNA FSGNKQNGSS RRKGSSSKNQ DKATLASRSA KKWVRLSYDG
210 220 230 240 250
VDPTSFIGLQ CKVFWPLDAL WYEGSIVGYS AERKRYTVKY RDGCDEDIVF
260 270 280 290 300
DREMIKFLVS REEMELLHLK FCTSNVTVDG RDYDEMVVLA ATLDECQDFE
310 320 330 340 350
PGDIVWAKLA GHAMWPAVIV DESIIGERKG LNNKVSGGGS LLVQFFGTHD
360 370 380 390 400
FARIKVKQAI SFIKGLLSPS HLKCKQPRFE EGMQEAKMYL KAHRLPERMS
410 420 430 440 450
QLQKGADSVD SDMANSTEEG NSGGDLLNDG EVWLRPTEHV DFRHIIGDLL
460 470 480 490 500
IINLGKVVTD SQFFKDENHI WPEGYTAMRK FTSLTDHSAS ALYKMEVLRD
510 520 530 540 550
AETKTHPLFI VTADSGEQFK GPTPSACWNK IYNRIKKVQN SDSPNILGEE
560 570 580 590 600
LNGSGTDMFG LSNPEVIKLV QDLSKSRPSS HVSMCKNSLG RHQNQPTGYR
610 620 630 640 650
PVRVDWKDLD KCNVCHMDEE YENNLFLQCD KCRMMVHAKC YGELEPCDGA
660 670 680 690 700
LWLCNLCRPG APDMPPRCCL CPVVGGAMKP TTDGRWAHLA CAIWIPETCL
710 720 730 740 750
SDVKKMEPID GVNKVSKDRW KLMCTICGVS YGACIQCSNN SCRVAYHPLC
760 770 780 790 800
ARAAGLCVEL ENDMSVEGEE ADQCIRMLSF CKRHRQTSTA CLGSEDRIKS
810 820 830 840 850
ATHKTSEYLP PPNPSGCART EPYNCFGRRG RKEPEALAAA SSKRLFVENQ
860 870 880 890 900
PYVIGGYSRL EFSTYKSIHG SKVSQMNTPS NILSMAEKYR YMRETYRKRL
910 920 930 940 950
AFGKSGIHGF GIFAKLPHRA GDMMIEYTGE LVRPSIADKR EQLIYNSMVG
960 970 980 990 1000
AGTYMFRIDD ERVIDATRTG SIAHLINHSC VPNCYSRVIT VNGDEHIIIF
1010 1020 1030 1040 1050
AKRHIPKWEE LTYDYRFFSI GERLSCSCGF PGCRGVVNDT EAEEQHAKIC
1060
VPRCDLIDWT AE
Length:1,062
Mass (Da):119,711
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8949A2C5F414B726
GO
Isoform 2 (identifier: Q9C5X4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-583: Missing.

Show »
Length:479
Mass (Da):54,058
Checksum:i8D11676D853E8509
GO
Isoform 3 (identifier: Q9C5X4-3) [UniParc]FASTAAdd to basket
Also known as: SoloSET1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-875: Missing.

Show »
Length:187
Mass (Da):21,423
Checksum:i173CDC7D3779EBB0
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD24842 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4F → V in AAK01237 (PubMed:11418242).Curated1
Sequence conflicti23R → H in AAK01237 (PubMed:11418242).Curated1
Sequence conflicti194V → I in AAK01237 (PubMed:11418242).Curated1
Sequence conflicti313A → S in AAK01237 (PubMed:11418242).Curated1
Sequence conflicti667R → Q in AAK01237 (PubMed:11418242).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0605261 – 875Missing in isoform 3. 1 PublicationAdd BLAST875
Alternative sequenceiVSP_0181321 – 583Missing in isoform 2. 1 PublicationAdd BLAST583

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF329273 mRNA Translation: AAK01237.1
AC007071 Genomic DNA Translation: AAD24842.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC08569.1
BT002941 mRNA Translation: AAO22754.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D84723

NCBI Reference Sequences

More...
RefSeqi
NP_850170.1, NM_179839.3 [Q9C5X4-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G31650.1; AT2G31650.1; AT2G31650 [Q9C5X4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
817721

Gramene; a comparative resource for plants

More...
Gramenei
AT2G31650.1; AT2G31650.1; AT2G31650 [Q9C5X4-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G31650

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329273 mRNA Translation: AAK01237.1
AC007071 Genomic DNA Translation: AAD24842.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC08569.1
BT002941 mRNA Translation: AAO22754.1
PIRiD84723
RefSeqiNP_850170.1, NM_179839.3 [Q9C5X4-1]

3D structure databases

SMRiQ9C5X4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi3068, 6 interactors
STRINGi3702.AT2G31650.1

Proteomic databases

PaxDbiQ9C5X4
PRIDEiQ9C5X4
ProteomicsDBi241094 [Q9C5X4-1]

Genome annotation databases

EnsemblPlantsiAT2G31650.1; AT2G31650.1; AT2G31650 [Q9C5X4-1]
GeneIDi817721
GrameneiAT2G31650.1; AT2G31650.1; AT2G31650 [Q9C5X4-1]
KEGGiath:AT2G31650

Organism-specific databases

AraportiAT2G31650
TAIRilocus:2065923, AT2G31650

Phylogenomic databases

eggNOGiKOG1080, Eukaryota
HOGENOMiCLU_005729_0_0_1
InParanoidiQ9C5X4
OMAiPYIVSGF
OrthoDBi181572at2759
PhylomeDBiQ9C5X4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9C5X4

Gene expression databases

ExpressionAtlasiQ9C5X4, baseline and differential
GenevisibleiQ9C5X4, AT

Family and domain databases

CDDicd15662, ePHD_ATX1_2_like, 1 hit
cd15494, PHD_ATX1_2_like, 1 hit
Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR041956, ATX1/2_ePHD
IPR042010, ATX1/2_PHD
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR019023, Lamin-B_rcpt_of_tudor
IPR002219, PE/DAG-bd
IPR003616, Post-SET_dom
IPR000313, PWWP_dom
IPR001214, SET_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF09465, LBR_tudor, 1 hit
PF00855, PWWP, 1 hit
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 2 hits
SM00293, PWWP, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50812, PWWP, 1 hit
PS50280, SET, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATX1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C5X4
Secondary accession number(s): Q84WP4, Q9SIP3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: June 2, 2021
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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