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Entry version 142 (07 Oct 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Histidine kinase 2

Gene

AHK2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokinins (CK) receptor related to bacterial two-component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin, feeds phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. Involved in meristems establishment in seedlings. Redundant negative regulator of drought and salt stress responses and abscisic acid (ABA) signaling. Together with AHK3, plays a negative regulatory role in cold stress signaling via inhibition of ABA response, occurring independently of the cold acclimation pathway. Redundant positive regulator of cytokinin signaling that regulates many developmental processes including seed germination, cell division, seed size, chlorophyll retention during leaf senescence, root repression and shoot promotion. Involved in alkamides (e.g. N-isobutyl decanamide) and N-acylethanolamides (NAE) signaling that control meristematic activity and differentiation processes during plant development. Contributes to vascular bundle formation and secondary growth in a cytokinin-dependent manner, probably by promoting the maintenance of mitotic activity and/or identity of procambial cells. Together with AHK4, required for growth and reproduction promotion stimulated by the endophytic fungus Piriformospora indica in a trans-zeatin-dependent manner. Required by the cytokinin-dependent flower development regulation pathway.12 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC:2.7.13.3

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by cytokinins to initiate phosphorelay signaling.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Transferase
Biological processCytokinin signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histidine kinase 2 (EC:2.7.13.3)
Alternative name(s):
Arabidopsis histidine kinase 2
Short name:
AtHK2
Protein AUTHENTIC HIS-KINASE 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AHK2
Ordered Locus Names:At5g35750
ORF Names:MXH1.16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G35750

The Arabidopsis Information Resource

More...
TAIRi
locus:2177261, AT5G35750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 174ExtracellularSequence analysisAdd BLAST124
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 232CytoplasmicSequence analysisAdd BLAST37
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 536ExtracellularSequence analysisAdd BLAST283
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Topological domaini558 – 1176CytoplasmicSequence analysisAdd BLAST619

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Hypersensitivity to ABA, and strong drought and salinity tolerance. Slightly reduced sensitivity to cytokinin. More rapid germination, reduced requirement for light, and decreased far-red light sensitivity. Reduced sensitivity to N-isobutyl decanamide. Defects in procambium proliferation and absence of secondary growth. Enhanced freezing tolerance. Impaired meristematic development in seedlings. Disturbed cytokinin-mediated flower development abnormality.10 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi418T → I: Loss of cyokinin-mediated activation. 1 Publication1
Mutagenesisi586I → A: Constitutively activated independently of cytokinin. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003985871 – 1176Histidine kinase 2Add BLAST1176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei597Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1
Modified residuei9424-aspartylphosphatePROSITE-ProRule annotation1
Modified residuei10864-aspartylphosphatePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated predominantly on His residues. Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C5U2

PRoteomics IDEntifications database

More...
PRIDEi
Q9C5U2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
245072

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C5U2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots, leaves and flowers, mostly in the vascular tissues. Present in seedlings.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In seedlings, mainly localized in meristematic tissues (e.g. shoot apical meristem SAM, root tips, and growing leaf and lateral root primordia). Present in all the vasculature and the shoot apical meristem (SAM) of the adult plant. In flowers, localized in carpels and developing ovules. In the root tips, expressed in and near the vascular initial cells.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Rapidly induced by dehydration, slightly induced by high salinity and abscisic acid (ABA).1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9C5U2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C5U2, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-interacts.

Interacts with AHK3, AHP1, AHP2, AHP3, AHP5, ATAF2, AT2S3, BETAA-AD, CYP20-2, DRP1A, HIR1, HIR2, PI4KB1, PI4KG5 and At4g12060.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
18805, 44 interactors

Protein interaction database and analysis system

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IntActi
Q9C5U2, 45 interactors

STRING: functional protein association networks

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STRINGi
3702.AT5G35750.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9C5U2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini302 – 526CHASEPROSITE-ProRule annotationAdd BLAST225
Domaini594 – 867Histidine kinasePROSITE-ProRule annotationAdd BLAST274
Domaini891 – 1013Response regulatory 1PROSITE-ProRule annotationAdd BLAST123
Domaini1036 – 1173Response regulatory 2PROSITE-ProRule annotationAdd BLAST138

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0519, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000445_16_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9C5U2

KEGG Orthology (KO)

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KOi
K14489

Identification of Orthologs from Complete Genome Data

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OMAi
EQGHIFI

Database of Orthologous Groups

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OrthoDBi
51398at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9C5U2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00082, HisKA, 1 hit
cd00156, REC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006189, CHASE_dom
IPR011006, CheY-like_superfamily
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR004358, Sig_transdc_His_kin-like_C
IPR001789, Sig_transdc_resp-reg_receiver

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03924, CHASE, 1 hit
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF00072, Response_reg, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00344, BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01079, CHASE, 1 hit
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit
SM00448, REC, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47384, SSF47384, 1 hit
SSF52172, SSF52172, 2 hits
SSF55874, SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50839, CHASE, 1 hit
PS50109, HIS_KIN, 1 hit
PS50110, RESPONSE_REGULATORY, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9C5U2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSITCELLNL TSKKAKKSSS SDKKWLKKPL FFLILCGSLV IVLVMFLRLG
60 70 80 90 100
RSQKEETDSC NGEEKVLYRH QNVTRSEIHD LVSLFSDSDQ VTSFECHKES
110 120 130 140 150
SPGMWTNYGI TCSLSVRSDK QETRGLPWNL GLGHSISSTS CMCGNLEPIL
160 170 180 190 200
QQPENLEEEN HEEGLEQGLS SYLRNAWWCL ILGVLVCHKI YVSHSKARGE
210 220 230 240 250
RKEKVHLQEA LAPKKQQQRA QTSSRGAGRW RKNILLLGIL GGVSFSVWWF
260 270 280 290 300
WDTNEEIIMK RRETLANMCD ERARVLQDQF NVSLNHVHAL SILVSTFHHG
310 320 330 340 350
KIPSAIDQRT FEEYTERTNF ERPLTSGVAY ALKVPHSERE KFEKEHGWAI
360 370 380 390 400
KKMETEDQTV VQDCVPENFD PAPIQDEYAP VIFAQETVSH IVSVDMMSGE
410 420 430 440 450
EDRENILRAR ASGKGVLTSP FKLLKSNHLG VVLTFAVYDT SLPPDATEEQ
460 470 480 490 500
RVEATIGYLG ASYDMPSLVE KLLHQLASKQ TIAVDVYDTT NTSGLIKMYG
510 520 530 540 550
SEIGDISEQH ISSLDFGDPS RNHEMHCRFK HKLPIPWTAI TPSILVLVIT
560 570 580 590 600
FLVGYILYEA INRIATVEED CQKMRELKAR AEAADIAKSQ FLATVSHEIR
610 620 630 640 650
TPMNGVLGML KMLMDTDLDA KQMDYAQTAH GSGKDLTSLI NEVLDQAKIE
660 670 680 690 700
SGRLELENVP FDMRFILDNV SSLLSGKANE KGIELAVYVS SQVPDVVVGD
710 720 730 740 750
PSRFRQIITN LVGNSIKFTQ ERGHIFISVH LADEVKEPLT IEDAVLKQRL
760 770 780 790 800
ALGCSESGET VSGFPAVNAW GSWKNFKTCY STESQNSDQI KLLVTVEDTG
810 820 830 840 850
VGIPVDAQGR IFTPFMQADS STSRTYGGTG IGLSISKRLV ELMQGEMGFV
860 870 880 890 900
SEPGIGSTFS FTGVFGKAET NTSITKLERF DLAIQEFTGL RALVIDNRNI
910 920 930 940 950
RAEVTRYELR RLGISADIVS SLRMACTCCI SKLENLAMIL IDKDAWNKEE
960 970 980 990 1000
FSVLDELFTR SKVTFTRVPK IFLLATSATL TERSEMKSTG LIDEVVIKPL
1010 1020 1030 1040 1050
RMSVLICCLQ ETLVNGKKRQ PNRQRRNLGH LLREKQILVV DDNLVNRRVA
1060 1070 1080 1090 1100
EGALKKYGAI VTCVESGKAA LAMLKPPHNF DACFMDLQMP EMDGFEATRR
1110 1120 1130 1140 1150
VRELEREINK KIASGEVSAE MFCKFSSWHV PILAMTADVI QATHEECMKC
1160 1170
GMDGYVSKPF EEEVLYTAVA RFFEPC
Length:1,176
Mass (Da):131,860
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC0019CC612361BC
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO00890 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB09274 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD43496 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1103E → K in BAD43496 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB046869 mRNA Translation: BAB40774.1
AB011485 Genomic DNA Translation: BAB09274.1 Sequence problems.
CP002688 Genomic DNA Translation: AED94014.1
BT002530 mRNA Translation: AAO00890.1 Different initiation.
BT008407 mRNA Translation: AAP37766.1
AK175733 mRNA Translation: BAD43496.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_568532.1, NM_122966.3

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT5G35750.1; AT5G35750.1; AT5G35750

Database of genes from NCBI RefSeq genomes

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GeneIDi
833552

Gramene; a comparative resource for plants

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Gramenei
AT5G35750.1; AT5G35750.1; AT5G35750

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT5G35750

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046869 mRNA Translation: BAB40774.1
AB011485 Genomic DNA Translation: BAB09274.1 Sequence problems.
CP002688 Genomic DNA Translation: AED94014.1
BT002530 mRNA Translation: AAO00890.1 Different initiation.
BT008407 mRNA Translation: AAP37766.1
AK175733 mRNA Translation: BAD43496.1 Different initiation.
RefSeqiNP_568532.1, NM_122966.3

3D structure databases

SMRiQ9C5U2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi18805, 44 interactors
IntActiQ9C5U2, 45 interactors
STRINGi3702.AT5G35750.1

PTM databases

iPTMnetiQ9C5U2

Proteomic databases

PaxDbiQ9C5U2
PRIDEiQ9C5U2
ProteomicsDBi245072

Genome annotation databases

EnsemblPlantsiAT5G35750.1; AT5G35750.1; AT5G35750
GeneIDi833552
GrameneiAT5G35750.1; AT5G35750.1; AT5G35750
KEGGiath:AT5G35750

Organism-specific databases

AraportiAT5G35750
TAIRilocus:2177261, AT5G35750

Phylogenomic databases

eggNOGiKOG0519, Eukaryota
HOGENOMiCLU_000445_16_1_1
InParanoidiQ9C5U2
KOiK14489
OMAiEQGHIFI
OrthoDBi51398at2759
PhylomeDBiQ9C5U2

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9C5U2

Gene expression databases

ExpressionAtlasiQ9C5U2, baseline and differential
GenevisibleiQ9C5U2, AT

Family and domain databases

CDDicd00082, HisKA, 1 hit
cd00156, REC, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR006189, CHASE_dom
IPR011006, CheY-like_superfamily
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR004358, Sig_transdc_His_kin-like_C
IPR001789, Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF03924, CHASE, 1 hit
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF00072, Response_reg, 1 hit
PRINTSiPR00344, BCTRLSENSOR
SMARTiView protein in SMART
SM01079, CHASE, 1 hit
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit
SM00448, REC, 1 hit
SUPFAMiSSF47384, SSF47384, 1 hit
SSF52172, SSF52172, 2 hits
SSF55874, SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50839, CHASE, 1 hit
PS50109, HIS_KIN, 1 hit
PS50110, RESPONSE_REGULATORY, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAHK2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C5U2
Secondary accession number(s): Q680Y4, Q8GUG0, Q9FKH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2001
Last modified: October 7, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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