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Entry version 128 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Histidine kinase 3

Gene

AHK3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokinins (CK) receptor related to bacterial two-component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin, feeds phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. Involved in meristems establishment in seedlings. Redundant negative regulator of drought and salt stress responses and abscisic acid (ABA) signaling. Together with AHK2, plays a negative regulatory role in cold stress signaling via inhibition of ABA response, occurring independently of the cold acclimation pathway. Redundant positive regulator of cytokinin signaling that regulates many developmental processes including seed germination, cell division, seed size, chlorophyll retention during leaf senescence, root repression and shoot promotion. Can interact with isoprenoid-type cytokinins trans-zeatin (tZ and tZR), cis-zeatin (cZ), dihydrozeatin (DZ), buta-2,3-dienyladenine (HA-8), penta-2,3-dienyladenine (HA-1), 4-methyl-penta-2,3-dienyladenine (HA-10), 4-hydroxy-2-butynyladenine (RM1), 2-propynyladenine (RM3), 2-butynyladenine (RM6), and cytokinin ribosides and ribotides. Together with AHK4, involved in the cytokinin-dependent responses to Pi starvation and sucrose stresses. Promotes cytokinin-mediated leaf longevity through a specific phosphorylation of the response regulator ARR2. Involved in alkamides (e.g. N-isobutyl decanamide) and N-acylethanolamides (NAE) signaling that control meristematic activity and differentiation processes during plant development. Contributes to vascular bundle formation and secondary growth in a cytokinin-dependent manner, probably by promoting the maintenance of mitotic activity and/or identity of procambial cells. Plays a role in the cytokinin-mediated repression of the iron uptake pathway. Required by the cytokinin-dependent flower development regulation pathway.19 Publications

Miscellaneous

'Oresara' means 'long living' in Korean.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC:2.7.13.3

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by cytokinins to initiate phosphorelay signaling. This cytokinin-mediated activation is repressed by the trans-zeatin antagonists 6-(2-hydroxy-3-methylbenzylamino)purine (PI-55) and 6-(2,5-Dihydroxybenzylamino)purine (LGR-991).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH to bind cytokinin is about 8.5 at 0 degrees Celsius.1 Publication

Temperature dependencei

Cytokinin-binding is stable at 0 degrees Celsius but transient at 37 degrees Celsius.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Transferase
Biological processCytokinin signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histidine kinase 3 (EC:2.7.13.3)
Alternative name(s):
Arabidopsis histidine kinase 3
Short name:
AtHK3
Protein AUTHENTIC HIS-KINASE 3
Protein ORESARA 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AHK3
Synonyms:ORE12
Ordered Locus Names:At1g27320
ORF Names:F17L21.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G27320

The Arabidopsis Information Resource

More...
TAIRi
locus:2015964, AT1G27320

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8ExtracellularSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 94CytoplasmicSequence analysisAdd BLAST65
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 399ExtracellularSequence analysisAdd BLAST284
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Topological domaini421 – 1036CytoplasmicSequence analysisAdd BLAST616

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Hypersensitivity to ABA, and strong drought and salinity tolerance. Reduced sensitivity to cytokinin (mostly in roots). More rapid germination, reduced requirement for light, and decreased far-red light sensitivity. Early senescence promoted by darkness. Reduced sensitivity to N-isobutyl decanamide. Defects in procambium proliferation and absence of secondary growth. Enhanced freezing tolerance. Impaired benzyladenine (6-BA)-mediated repression of the iron uptake pathway. Disturbed cytokinin-mediated flower development abnormality. Impaired meristematic development in seedlings.11 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi243P → S in ore12-1; delayed leaf senescence and abolished cytokinin-dependent phosphorylation activity toward ARR2. 1 Publication1
Mutagenesisi281T → I: Loss of cyokinin-mediated activation. 1 Publication1
Mutagenesisi448D → N: Delayed leaf senescence. 1 Publication1
Mutagenesisi449V → A: Constitutively activated independently of cytokinin. 1 Publication1
Mutagenesisi713S → F in ahk3-4; reduced sensitivity to cytokinin (mostly in roots), and impaired cytokinin repression of several Pi starvation-responsive genes and increased sucrose sensitivity. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6125

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003985881 – 1036Histidine kinase 3Add BLAST1036

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei460Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1
Modified residuei9414-aspartylphosphatePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated predominantly on His residues. Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C5U1

PRoteomics IDEntifications database

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PRIDEi
Q9C5U1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
244661

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly expressed in leaves and flowers, and, to a lower extent, in roots, stems, and siliques, especially in the vascular tissues. Present in seedlings.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In seedlings, mainly localized in meristematic tissues (e.g. shoot apical meristem SAM, root tips, and growing leaf and lateral root primordia). Present in all the vasculature and the shoot apical meristem (SAM) of the adult plant. In the root tips, strongest expression in the procambium.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Rapidly induced by dehydration, high salinity and cold stresses.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9C5U1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C5U1, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AHK2, AHK4, AHP1, AHP2, AHP3, AHP5 and At5g43560.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
24856, 7 interactors

Protein interaction database and analysis system

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IntActi
Q9C5U1, 7 interactors

STRING: functional protein association networks

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STRINGi
3702.AT1G27320.1

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9C5U1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9C5U1

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini163 – 389CHASEPROSITE-ProRule annotationAdd BLAST227
Domaini457 – 723Histidine kinasePROSITE-ProRule annotationAdd BLAST267
Domaini746 – 865Response regulatory 1PROSITE-ProRule annotationAdd BLAST120
Domaini891 – 1028Response regulatory 2PROSITE-ProRule annotationAdd BLAST138

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0519, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000445_16_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9C5U1

KEGG Orthology (KO)

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KOi
K14489

Identification of Orthologs from Complete Genome Data

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OMAi
FHHAKNP

Database of Orthologous Groups

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OrthoDBi
51398at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9C5U1

Family and domain databases

Conserved Domains Database

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CDDi
cd00082, HisKA, 1 hit
cd06223, PRTases_typeI, 1 hit
cd00156, REC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006189, CHASE_dom
IPR011006, CheY-like_superfamily
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR000836, PRibTrfase_dom
IPR004358, Sig_transdc_His_kin-like_C
IPR001789, Sig_transdc_resp-reg_receiver

Pfam protein domain database

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Pfami
View protein in Pfam
PF03924, CHASE, 1 hit
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF00072, Response_reg, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00344, BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01079, CHASE, 1 hit
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit
SM00448, REC, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47384, SSF47384, 1 hit
SSF52172, SSF52172, 2 hits
SSF55874, SSF55874, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50839, CHASE, 1 hit
PS50109, HIS_KIN, 1 hit
PS50110, RESPONSE_REGULATORY, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9C5U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLFHVLGFG VKIGHLFWML CCWFVSWFVD NGIEDKSGLL VGSVGDLEKT
60 70 80 90 100
KMTTLKKKNK MWFWNKISSS GLKIPSFSYQ FLGSVKFNKA WWRKLVVVWV
110 120 130 140 150
VFWVLVSIWT FWYFSSQAME KRKETLASMC DERARMLQDQ FNVSMNHVQA
160 170 180 190 200
MSILISTFHH GKIPSAIDQR TFSEYTDRTS FERPLTSGVA YAMRVLHSER
210 220 230 240 250
EEFERQQGWT IRKMYSLEQN PVHKDDYDLE ALEPSPVQEE YAPVIFAQDT
260 270 280 290 300
VSHVVSLDML SGKEDRENVL RARSSGKGVL TAPFPLIKTN RLGVILTFAV
310 320 330 340 350
YKRDLPSNAT PKERIEATNG YLGGVFDIES LVENLLQQLA SKQTILVNVY
360 370 380 390 400
DITNHSQPIS MYGTNVSADG LERVSPLIFG DPLRKHEMRC RFKQKPPWPV
410 420 430 440 450
LSMVTSFGIL VIALLVAHII HATVSRIHKV EEDCDKMKQL KKKAEAADVA
460 470 480 490 500
KSQFLATVSH EIRTPMNGVL GMLHMLMDTE LDVTQQDYVR TAQASGKALV
510 520 530 540 550
SLINEVLDQA KIESGKLELE EVRFDLRGIL DDVLSLFSSK SQQKGVELAV
560 570 580 590 600
YISDRVPDML IGDPGRFRQI LTNLMGNSIK FTEKGHIFVT VHLVDELFES
610 620 630 640 650
IDGETASSPE STLSGLPVAD RQRSWENFKA FSSNGHRSFE PSPPDINLIV
660 670 680 690 700
SVEDTGVGIP VEAQSRIFTP FMQVGPSISR THGGTGIGLS ISKCLVGLMK
710 720 730 740 750
GEIGFSSTPK VGSTFTFTAV FSNGMQPAER KNDNNQPIFS EFRGMKAVVV
760 770 780 790 800
DHRPARAKVS WYHFQRLGIR VEVVPRVEQA LHYLKIGTTT VNMILIEQEI
810 820 830 840 850
WNREADDFIK KLQKDPLFLS PKLILLANSV ESSISEALCT GIDPPIVIVK
860 870 880 890 900
PLRASMLAAT LQRGLGIGIR EPPQHKGPPA LILRNLLLGR KILIVDDNNV
910 920 930 940 950
NLRVAAGALK KYGADVVCAE SGIKAISLLK PPHEFDACFM DIQMPEMDGF
960 970 980 990 1000
EATRRIRDME EEMNKRIKNG EALIVENGNK TSWHLPVLAM TADVIQATHE
1010 1020 1030
ECLKCGMDGY VSKPFEAEQL YREVSRFFNS PSDTES
Length:1,036
Mass (Da):116,373
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03F23DEE4B44C40B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF99730 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB046870 mRNA Translation: BAB40775.1
AC004557 Genomic DNA Translation: AAF99730.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30806.1

NCBI Reference Sequences

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RefSeqi
NP_564276.1, NM_102494.4

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT1G27320.1; AT1G27320.1; AT1G27320

Database of genes from NCBI RefSeq genomes

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GeneIDi
839621

Gramene; a comparative resource for plants

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Gramenei
AT1G27320.1; AT1G27320.1; AT1G27320

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT1G27320

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046870 mRNA Translation: BAB40775.1
AC004557 Genomic DNA Translation: AAF99730.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30806.1
RefSeqiNP_564276.1, NM_102494.4

3D structure databases

SMRiQ9C5U1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi24856, 7 interactors
IntActiQ9C5U1, 7 interactors
STRINGi3702.AT1G27320.1

Chemistry databases

BindingDBiQ9C5U1
ChEMBLiCHEMBL6125

Proteomic databases

PaxDbiQ9C5U1
PRIDEiQ9C5U1
ProteomicsDBi244661

Genome annotation databases

EnsemblPlantsiAT1G27320.1; AT1G27320.1; AT1G27320
GeneIDi839621
GrameneiAT1G27320.1; AT1G27320.1; AT1G27320
KEGGiath:AT1G27320

Organism-specific databases

AraportiAT1G27320
TAIRilocus:2015964, AT1G27320

Phylogenomic databases

eggNOGiKOG0519, Eukaryota
HOGENOMiCLU_000445_16_2_1
InParanoidiQ9C5U1
KOiK14489
OMAiFHHAKNP
OrthoDBi51398at2759
PhylomeDBiQ9C5U1

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9C5U1

Gene expression databases

ExpressionAtlasiQ9C5U1, baseline and differential
GenevisibleiQ9C5U1, AT

Family and domain databases

CDDicd00082, HisKA, 1 hit
cd06223, PRTases_typeI, 1 hit
cd00156, REC, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR006189, CHASE_dom
IPR011006, CheY-like_superfamily
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR000836, PRibTrfase_dom
IPR004358, Sig_transdc_His_kin-like_C
IPR001789, Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF03924, CHASE, 1 hit
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF00072, Response_reg, 1 hit
PRINTSiPR00344, BCTRLSENSOR
SMARTiView protein in SMART
SM01079, CHASE, 1 hit
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit
SM00448, REC, 2 hits
SUPFAMiSSF47384, SSF47384, 1 hit
SSF52172, SSF52172, 2 hits
SSF55874, SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50839, CHASE, 1 hit
PS50109, HIS_KIN, 1 hit
PS50110, RESPONSE_REGULATORY, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAHK3_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C5U1
Secondary accession number(s): Q9FZK3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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