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Entry version 140 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Histidine kinase 4

Gene

AHK4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokinins (CK) receptor related to bacterial two-component regulators. Binds also the synthetic urea-type cytokinin thiadiazuron, a potent defoliant and herbicide. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin, feeds phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. In the absence of cytokinin, removes phosphate from HPt proteins, decreasing the system phosphoload. Involved in meristems establishment in seedlings. Acts as a redundant negative regulator of drought and salt stress responses, and abscisic acid (ABA) signaling in a cytokinin-dependent manner. Required to set vascular asymmetric cell divisions that establish phloem and procambium cell lines. Redundant positive regulator of cytokinin signaling that regulates many developmental processes including seed germination, cell division, seed size, chlorophyll retention during leaf senescence, root repression and shoot promotion. Can interact with isoprenoid-type cytokinins trans-zeatin (tZ and tZR), isopentenyladenine (iP), and isopentenyladenosine (iPR), the meta hydroxylated derivative of benzyladenine m-topolin, buta-2,3-dienyladenine (HA-8), penta-2,3-dienyladenine (HA-1), 4-methyl-penta-2,3-dienyladenine (HA-10), 4-hydroxy-2-butynyladenine (RM1), 2-butynyladenine (RM6), and to a lower extent, with cis-zeatin (cZ), zeatin riboside and dihydrozeatin (DZ). Together with AHK3, involved in the cytokinin-dependent responses to Pi starvation and sucrose stresses. Required for the formation of auxin-transporting vascular tissues in the hypocotyl, and primary and lateral roots, but not in adventitious roots, thus leading to auxin basipetal transport that regulates root development and branching. Involved in alkamides (e.g. N-isobutyl decanamide) and N-acylethanolamides (NAE) signaling that control meristematic activity and differentiation processes during plant development. Prevents the uptake of sulfate by mediating cytokinin-dependent down-regulation of high-affinity sulfate transporters (e.g. SULTR1;1 and SULTR1;2) expression in roots. Together with AHK2, required for growth and reproduction promotion stimulated by the endophytic fungus Piriformospora indica in a trans-zeatin-dependent manner. Required to trigger the phytotoxic effect of the snapdragon (Antirrhinum majus) flowers volatile organic compound (VOC) methyl benzoate (MB). Plays a role in the cytokinin-mediated repression of the iron uptake pathway.28 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC:2.7.13.3

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by cytokinins to initiate phosphorelay signaling. This cytokinin-mediated activation is repressed by the trans-zeatin antagonists 6-(2-hydroxy-3-methylbenzylamino)purine (PI-55) and 6-(2,5-Dihydroxybenzylamino)purine (LGR-991).3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH to bind cytokinin is about 7-8.5 at 0 degrees Celsius.2 Publications

Temperature dependencei

Cytokinin-binding is more stable at 0 degrees Celsius than at 20 and 37 degrees Celsius.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei285Cytokinin1
Binding sitei307Cytokinin; via amide nitrogen1
Binding sitei317Cytokinin1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Kinase, Protein phosphatase, Transferase
Biological processCytokinin signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histidine kinase 4 (EC:2.7.13.3)
Alternative name(s):
Arabidopsis histidine kinase 4
Short name:
AtHK4
Cytokinin receptor CYTOKININ RESPONSE 1
Short name:
AtCRE1
Short name:
Cytokinin receptor CRE1
Phosphoprotein phosphatase AHK4 (EC:3.1.3.16)
Protein AUTHENTIC HIS-KINASE 4
Protein ROOT AS IN WOL 1
Protein WOODEN LEG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AHK4
Synonyms:CRE1, RAW1, WOL
Ordered Locus Names:At2g01830
ORF Names:T23K3.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G01830

The Arabidopsis Information Resource

More...
TAIRi
locus:2059718, AT2G01830

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 124CytoplasmicSequence analysisAdd BLAST124
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 429ExtracellularSequence analysisAdd BLAST284
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 1080CytoplasmicSequence analysisAdd BLAST630

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Reduced sensitivity to cytokinin (mostly in shoots). Narrow vascular cylinder composed mainly of protoxylem cell files, with no apparent metaxylem or phloem. Hypersensitivity to ABA. Strong drought and salinity tolerance only in the presence of CK. Reduced cytokinin repression of several Pi starvation-responsive genes and increased sucrose sensitivity. More rapid germination, reduced requirement for light, and decreased far-red light sensitivity. Reduced sensitivity to N-isobutyl decanamide. Impaired benzyladenine (6-BA)-mediated repression of the iron uptake pathway. Impaired meristematic development in seedlings.12 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi225A → L: Loss of activity. 1 Publication1
Mutagenesisi227A → L: Loss of activity. 1 Publication1
Mutagenesisi273Y → E: Loss of activity. 1 Publication1
Mutagenesisi279M → A: No effect on activity. 1 Publication1
Mutagenesisi285D → A, E or R: Loss of activity. 1 Publication1
Mutagenesisi301T → I in wol-1; locked in the phosphoprotein phosphatase active form, retardation of the primary root growth with reduced cell number and exclusive xylem differentiation within the vascular tissue associated with abnormal vascular asymmetric cell divisions, impaired metaxylem and phloem differentiation, and reduced cytokinin-binding ability leading to impaired kinase activity and cyokinin-mediated activation. 6 Publications1
Mutagenesisi303P → V: Loss of activity. 1 Publication1
Mutagenesisi304F → A: Loss of activity. 1 Publication1
Mutagenesisi306L → A: Loss of activity. 1 Publication1
Mutagenesisi307L → A: Loss of activity. 1 Publication1
Mutagenesisi317T → A: No effect on activity. 1 Publication1
Mutagenesisi343G → L: Loss of activity. 1 Publication1
Mutagenesisi435G → C: Constitutively activated independently of cytokinin. 1 Publication1
Mutagenesisi436F → S: Constitutively activated independently of cytokinin. 1 Publication1
Mutagenesisi447M → T: Constitutively activated independently of cytokinin. 1 Publication1
Mutagenesisi459M → I in wol-3; retardation of the primary root growth, no production of lateral roots and enhanced formation of adventitious roots associated with impaired auxin basipetal transport. 1 Publication1
Mutagenesisi471V → A: Constitutively activated independently of cytokinin. 1 Publication1
Mutagenesisi482H → Q: Reduced phosphoprotein phosphatase activity. 2 Publications1
Mutagenesisi490G → D in cre1-1; impaired histidine-kinase receptor activity and reduced responses to cytokinins, including rapid cell proliferation and shoot formation in tissue culture, repression of sulfate uptake, retardation of the primary root growth, no production of lateral roots and enhanced formation of adventitious roots associated with impaired auxin basipetal transport, as well as reduced cell number within the vascular tissues in roots. 4 Publications1
Mutagenesisi493G → R in cre1-6; reduced sensitivity to cytokinin. 1 Publication1
Mutagenesisi494M → L: Constitutively activated independently of cytokinin. 1 Publication1
Mutagenesisi529L → F in wol-2/raw1; impaired metaxylem and phloem differentiation, and reduced sensitivity to cytokinins. 1 Publication1
Mutagenesisi529L → F in wol-2; retardation of the primary root growth with reduced cell number and exclusive xylem differentiation within the vascular tissue associated with abnormal vascular asymmetric cell divisions, and impaired cytokinin-binding ability. 1 Publication1
Mutagenesisi708F → L: No histidine kinase activity, but normal phosphoprotein phosphatase activity. 1 Publication1
Mutagenesisi996D → N: Cytokinin-mediated autophosphorylation but impaired phosphotransfer to an HPt, abolished phosphoprotein phosphatase activity. 2 Publications1
Mutagenesisi1008T → I in cre1-4; slightly reduced sensitivity to cytokinin, and impaired cytokinin repression of several Pi starvation-responses. 1 Publication1
Mutagenesisi1032A → T in cre1-9; impaired cytokinin repression of several Pi starvation-responses. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6124

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003985891 – 1080Histidine kinase 4Add BLAST1080

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei482Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1 Publication1
Modified residuei9964-aspartylphosphatePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated predominantly on His residues. Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9C5U0

PRoteomics IDEntifications database

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PRIDEi
Q9C5U0

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
244933 [Q9C5U0-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C5U0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly expressed in roots, specifically in the vascular cylinder and pericycle, and, to a lower extent, in leaves and flowers. Present in seedlings.4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed specifically in the vasculature since the early stages of embryogenesis. At the globular stage of embryogenesis, detected in the four innermost cells, which are the precursors of the vascular tissue. During the heart, torpedo, and nearly mature stages, expressed in the procambium of the cotyledon shoulders, prospective hypocotyl, and embryonic root. In seedlings, mainly localized in meristematic tissues (e.g. shoot apical meristem SAM, root tips, and growing leaf and lateral root primordia), especially in vasculature. Present in all the vasculature and the shoot apical meristem (SAM) of the adult plant. In flowers, localized in carpels and developing ovules. In the root tips, expressed in the central cylinder.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Rapidly induced by dehydration. Down-regulated by Pi starvation and induced by cytokinins.2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9C5U0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C5U0, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with AHP1, AHP2, AHP3, AHP5, AHK3, AMPD, FBR12, WNK5 and At4g15630.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
117, 32 interactors

Protein interaction database and analysis system

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IntActi
Q9C5U0, 29 interactors

STRING: functional protein association networks

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STRINGi
3702.AT2G01830.2

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9C5U0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11080
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9C5U0

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9C5U0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini198 – 411CHASEPROSITE-ProRule annotationAdd BLAST214
Domaini479 – 760Histidine kinasePROSITE-ProRule annotationAdd BLAST282
Domaini786 – 920Response regulatory 1PROSITE-ProRule annotationAdd BLAST135
Domaini946 – 1071Response regulatory 2PROSITE-ProRule annotationAdd BLAST126

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi823 – 826Poly-Ala4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0519, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9C5U0

KEGG Orthology (KO)

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KOi
K14489

Database of Orthologous Groups

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OrthoDBi
51398at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9C5U0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00082, HisKA, 1 hit
cd06223, PRTases_typeI, 1 hit
cd00156, REC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006189, CHASE_dom
IPR011006, CheY-like_superfamily
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR000836, PRibTrfase_dom
IPR004358, Sig_transdc_His_kin-like_C
IPR001789, Sig_transdc_resp-reg_receiver

Pfam protein domain database

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Pfami
View protein in Pfam
PF03924, CHASE, 1 hit
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF00072, Response_reg, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00344, BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01079, CHASE, 1 hit
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit
SM00448, REC, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47384, SSF47384, 1 hit
SSF52172, SSF52172, 2 hits
SSF55874, SSF55874, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50839, CHASE, 1 hit
PS50109, HIS_KIN, 1 hit
PS50110, RESPONSE_REGULATORY, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C5U0-1) [UniParc]FASTAAdd to basket
Also known as: CRE1b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRDFVYNNN AMFNPLTTHY SSDMNWALNN HQEEEEEPRR IEISDSESLE
60 70 80 90 100
NLKSSDFYQL GGGGALNSSE KPRKIDFWRS GLMGFAKMQQ QQQLQHSVAV
110 120 130 140 150
KMNNNNNNDL MGNKKGSTFI QEHRALLPKA LILWIIIVGF ISSGIYQWMD
160 170 180 190 200
DANKIRREEV LVSMCDQRAR MLQDQFSVSV NHVHALAILV STFHYHKNPS
210 220 230 240 250
AIDQETFAEY TARTAFERPL LSGVAYAEKV VNFEREMFER QHNWVIKTMD
260 270 280 290 300
RGEPSPVRDE YAPVIFSQDS VSYLESLDMM SGEEDRENIL RARETGKAVL
310 320 330 340 350
TSPFRLLETH HLGVVLTFPV YKSSLPENPT VEERIAATAG YLGGAFDVES
360 370 380 390 400
LVENLLGQLA GNQAIVVHVY DITNASDPLV MYGNQDEEAD RSLSHESKLD
410 420 430 440 450
FGDPFRKHKM ICRYHQKAPI PLNVLTTVPL FFAIGFLVGY ILYGAAMHIV
460 470 480 490 500
KVEDDFHEMQ ELKVRAEAAD VAKSQFLATV SHEIRTPMNG ILGMLAMLLD
510 520 530 540 550
TELSSTQRDY AQTAQVCGKA LIALINEVLD RAKIEAGKLE LESVPFDIRS
560 570 580 590 600
ILDDVLSLFS EESRNKSIEL AVFVSDKVPE IVKGDSGRFR QIIINLVGNS
610 620 630 640 650
VKFTEKGHIF VKVHLAEQSK DESEPKNALN GGVSEEMIVV SKQSSYNTLS
660 670 680 690 700
GYEAADGRNS WDSFKHLVSE EQSLSEFDIS SNVRLMVSIE DTGIGIPLVA
710 720 730 740 750
QGRVFMPFMQ ADSSTSRNYG GTGIGLSISK CLVELMRGQI NFISRPHIGS
760 770 780 790 800
TFWFTAVLEK CDKCSAINHM KKPNVEHLPS TFKGMKAIVV DAKPVRAAVT
810 820 830 840 850
RYHMKRLGIN VDVVTSLKTA VVAAAAFERN GSPLPTKPQL DMILVEKDSW
860 870 880 890 900
ISTEDNDSEI RLLNSRTNGN VHHKSPKLAL FATNITNSEF DRAKSAGFAD
910 920 930 940 950
TVIMKPLRAS MIGACLQQVL ELRKTRQQHP EGSSPATLKS LLTGKKILVV
960 970 980 990 1000
DDNIVNRRVA AGALKKFGAE VVCAESGQVA LGLLQIPHTF DACFMDIQMP
1010 1020 1030 1040 1050
QMDGFEATRQ IRMMEKETKE KTNLEWHLPI LAMTADVIHA TYEECLKSGM
1060 1070 1080
DGYVSKPFEE ENLYKSVAKS FKPNPISPSS
Length:1,080
Mass (Da):120,731
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5950DB968B529401
GO
Isoform 2 (identifier: Q9C5U0-2) [UniParc]FASTAAdd to basket
Also known as: CRE1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:1,057
Mass (Da):117,955
Checksum:iE1381C8685F0D787
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B026A0A1P8B026_ARATH
Histidine kinase
WOL AHK4, ARABIDOPSIS HISTIDINE KINASE 4, ATCRE1, CRE1, CYTOKININ RESPONSE 1
1,069Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti567S → G in BAB33311 (PubMed:11234017).Curated1
Sequence conflicti1018T → A in BAB33311 (PubMed:11234017).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti765S → N in strain: cv. Se-0. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0397701 – 23Missing in isoform 2. 3 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ278528 mRNA Translation: CAC18521.1
AJ278529 mRNA Translation: CAC18522.1
AJ278530 mRNA Translation: CAC18523.1
AB049934 mRNA Translation: BAB33310.1
AB049935 mRNA Translation: BAB33311.1
AB046871 mRNA Translation: BAB40776.1
AC007069 Genomic DNA Translation: AAD21777.2
CP002685 Genomic DNA Translation: AEC05505.1
CP002685 Genomic DNA Translation: AEC05506.1
CP002685 Genomic DNA Translation: AEC05507.1
CP002685 Genomic DNA Translation: ANM62256.1
CP002685 Genomic DNA Translation: ANM62257.1
EF598292 Genomic DNA Translation: ABQ85264.1
EF598293 Genomic DNA Translation: ABQ85265.1
EF598294 Genomic DNA Translation: ABQ85266.1
EF598295 Genomic DNA Translation: ABQ85267.1
EF598296 Genomic DNA Translation: ABQ85268.1
EF598297 Genomic DNA Translation: ABQ85269.1
EF598298 Genomic DNA Translation: ABQ85270.1
EF598299 Genomic DNA Translation: ABQ85271.1
EF598300 Genomic DNA Translation: ABQ85272.1
EF598301 Genomic DNA Translation: ABQ85273.1
EF598302 Genomic DNA Translation: ABQ85274.1
EF598303 Genomic DNA Translation: ABQ85275.1
EF598304 Genomic DNA Translation: ABQ85276.1
EF598305 Genomic DNA Translation: ABQ85277.1
EF598306 Genomic DNA Translation: ABQ85278.1
EF598307 Genomic DNA Translation: ABQ85279.1
EF598308 Genomic DNA Translation: ABQ85280.1
EF598309 Genomic DNA Translation: ABQ85281.1
EF598310 Genomic DNA Translation: ABQ85282.1
EF598311 Genomic DNA Translation: ABQ85283.1
EF598312 Genomic DNA Translation: ABQ85284.1
EF598313 Genomic DNA Translation: ABQ85285.1
EF598314 Genomic DNA Translation: ABQ85286.1
EF598315 Genomic DNA Translation: ABQ85287.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F84429

NCBI Reference Sequences

More...
RefSeqi
NP_001324428.1, NM_001335080.1 [Q9C5U0-2]
NP_001324429.1, NM_001335082.1 [Q9C5U0-2]
NP_565277.1, NM_126244.3 [Q9C5U0-2]
NP_849925.1, NM_179594.2 [Q9C5U0-1]
NP_973396.1, NM_201667.1 [Q9C5U0-2]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G01830.1; AT2G01830.1; AT2G01830 [Q9C5U0-2]
AT2G01830.2; AT2G01830.2; AT2G01830 [Q9C5U0-1]
AT2G01830.3; AT2G01830.3; AT2G01830 [Q9C5U0-2]
AT2G01830.4; AT2G01830.4; AT2G01830 [Q9C5U0-2]
AT2G01830.6; AT2G01830.6; AT2G01830 [Q9C5U0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
814714

Gramene; a comparative resource for plants

More...
Gramenei
AT2G01830.1; AT2G01830.1; AT2G01830 [Q9C5U0-2]
AT2G01830.2; AT2G01830.2; AT2G01830 [Q9C5U0-1]
AT2G01830.3; AT2G01830.3; AT2G01830 [Q9C5U0-2]
AT2G01830.4; AT2G01830.4; AT2G01830 [Q9C5U0-2]
AT2G01830.6; AT2G01830.6; AT2G01830 [Q9C5U0-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G01830

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278528 mRNA Translation: CAC18521.1
AJ278529 mRNA Translation: CAC18522.1
AJ278530 mRNA Translation: CAC18523.1
AB049934 mRNA Translation: BAB33310.1
AB049935 mRNA Translation: BAB33311.1
AB046871 mRNA Translation: BAB40776.1
AC007069 Genomic DNA Translation: AAD21777.2
CP002685 Genomic DNA Translation: AEC05505.1
CP002685 Genomic DNA Translation: AEC05506.1
CP002685 Genomic DNA Translation: AEC05507.1
CP002685 Genomic DNA Translation: ANM62256.1
CP002685 Genomic DNA Translation: ANM62257.1
EF598292 Genomic DNA Translation: ABQ85264.1
EF598293 Genomic DNA Translation: ABQ85265.1
EF598294 Genomic DNA Translation: ABQ85266.1
EF598295 Genomic DNA Translation: ABQ85267.1
EF598296 Genomic DNA Translation: ABQ85268.1
EF598297 Genomic DNA Translation: ABQ85269.1
EF598298 Genomic DNA Translation: ABQ85270.1
EF598299 Genomic DNA Translation: ABQ85271.1
EF598300 Genomic DNA Translation: ABQ85272.1
EF598301 Genomic DNA Translation: ABQ85273.1
EF598302 Genomic DNA Translation: ABQ85274.1
EF598303 Genomic DNA Translation: ABQ85275.1
EF598304 Genomic DNA Translation: ABQ85276.1
EF598305 Genomic DNA Translation: ABQ85277.1
EF598306 Genomic DNA Translation: ABQ85278.1
EF598307 Genomic DNA Translation: ABQ85279.1
EF598308 Genomic DNA Translation: ABQ85280.1
EF598309 Genomic DNA Translation: ABQ85281.1
EF598310 Genomic DNA Translation: ABQ85282.1
EF598311 Genomic DNA Translation: ABQ85283.1
EF598312 Genomic DNA Translation: ABQ85284.1
EF598313 Genomic DNA Translation: ABQ85285.1
EF598314 Genomic DNA Translation: ABQ85286.1
EF598315 Genomic DNA Translation: ABQ85287.1
PIRiF84429
RefSeqiNP_001324428.1, NM_001335080.1 [Q9C5U0-2]
NP_001324429.1, NM_001335082.1 [Q9C5U0-2]
NP_565277.1, NM_126244.3 [Q9C5U0-2]
NP_849925.1, NM_179594.2 [Q9C5U0-1]
NP_973396.1, NM_201667.1 [Q9C5U0-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T4JX-ray1.65A/B149-418[»]
3T4KX-ray1.77A/B149-418[»]
3T4LX-ray1.53A/B149-418[»]
3T4OX-ray1.75A/B149-418[»]
3T4QX-ray2.30A/B149-418[»]
3T4SX-ray1.60A/B149-418[»]
3T4TX-ray1.70A/B149-418[»]
SMRiQ9C5U0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117, 32 interactors
IntActiQ9C5U0, 29 interactors
STRINGi3702.AT2G01830.2

Chemistry databases

BindingDBiQ9C5U0
ChEMBLiCHEMBL6124

PTM databases

iPTMnetiQ9C5U0

Proteomic databases

PaxDbiQ9C5U0
PRIDEiQ9C5U0
ProteomicsDBi244933 [Q9C5U0-1]

Genome annotation databases

EnsemblPlantsiAT2G01830.1; AT2G01830.1; AT2G01830 [Q9C5U0-2]
AT2G01830.2; AT2G01830.2; AT2G01830 [Q9C5U0-1]
AT2G01830.3; AT2G01830.3; AT2G01830 [Q9C5U0-2]
AT2G01830.4; AT2G01830.4; AT2G01830 [Q9C5U0-2]
AT2G01830.6; AT2G01830.6; AT2G01830 [Q9C5U0-2]
GeneIDi814714
GrameneiAT2G01830.1; AT2G01830.1; AT2G01830 [Q9C5U0-2]
AT2G01830.2; AT2G01830.2; AT2G01830 [Q9C5U0-1]
AT2G01830.3; AT2G01830.3; AT2G01830 [Q9C5U0-2]
AT2G01830.4; AT2G01830.4; AT2G01830 [Q9C5U0-2]
AT2G01830.6; AT2G01830.6; AT2G01830 [Q9C5U0-2]
KEGGiath:AT2G01830

Organism-specific databases

AraportiAT2G01830
TAIRilocus:2059718, AT2G01830

Phylogenomic databases

eggNOGiKOG0519, Eukaryota
InParanoidiQ9C5U0
KOiK14489
OrthoDBi51398at2759
PhylomeDBiQ9C5U0

Miscellaneous databases

EvolutionaryTraceiQ9C5U0

Protein Ontology

More...
PROi
PR:Q9C5U0

Gene expression databases

ExpressionAtlasiQ9C5U0, baseline and differential
GenevisibleiQ9C5U0, AT

Family and domain databases

CDDicd00082, HisKA, 1 hit
cd06223, PRTases_typeI, 1 hit
cd00156, REC, 1 hit
InterProiView protein in InterPro
IPR006189, CHASE_dom
IPR011006, CheY-like_superfamily
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR000836, PRibTrfase_dom
IPR004358, Sig_transdc_His_kin-like_C
IPR001789, Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF03924, CHASE, 1 hit
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF00072, Response_reg, 1 hit
PRINTSiPR00344, BCTRLSENSOR
SMARTiView protein in SMART
SM01079, CHASE, 1 hit
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit
SM00448, REC, 1 hit
SUPFAMiSSF47384, SSF47384, 1 hit
SSF52172, SSF52172, 2 hits
SSF55874, SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50839, CHASE, 1 hit
PS50109, HIS_KIN, 1 hit
PS50110, RESPONSE_REGULATORY, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAHK4_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C5U0
Secondary accession number(s): A5YY60
, A5YY75, Q9C5T8, Q9C5T9, Q9FDZ3, Q9SIT0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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