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Entry version 117 (11 Dec 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Lupeol synthase 1

Gene

LUP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional enzyme that converts oxidosqualene to lupeol and 3,20-dihydroxylupane. Minor production of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei483Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Lyase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:GQT-1793-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.2.1.128 399
5.4.99.41 399

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lupeol synthase 1 (EC:4.2.1.128, EC:5.4.99.41)
Short name:
AtLUP1
Alternative name(s):
Lupan-3-beta,20-diol synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LUP1
Ordered Locus Names:At1g78970
ORF Names:YUP8H12R.28, YUP8H12R.42
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G78970

The Arabidopsis Information Resource

More...
TAIRi
locus:2207310 AT1G78970

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003661311 – 757Lupeol synthase 1Add BLAST757

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C5M3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C5M3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C5M3 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
29456, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9C5M3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G78970.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9C5M3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati149 – 190PFTB 1Add BLAST42
Repeati589 – 629PFTB 2Add BLAST41
Repeati638 – 679PFTB 3Add BLAST42

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0497 Eukaryota
COG1657 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234317

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C5M3

KEGG Orthology (KO)

More...
KOi
K15816

Identification of Orthologs from Complete Genome Data

More...
OMAi
EFMANTM

Database of Orthologous Groups

More...
OrthoDBi
365003at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C5M3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02892 SQCY_1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032696 SQ_cyclase_C
IPR032697 SQ_cyclase_N
IPR018333 Squalene_cyclase
IPR002365 Terpene_synthase_CS
IPR008930 Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13243 SQHop_cyclase_C, 1 hit
PF13249 SQHop_cyclase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239 SSF48239, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01787 squalene_cyclas, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01074 TERPENE_SYNTHASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9C5M3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWKLKIGKGN GEDPHLFSSN NFVGRQTWKF DHKAGSPEER AAVEEARRGF
60 70 80 90 100
LDNRFRVKGC SDLLWRMQFL REKKFEQGIP QLKATNIEEI TYETTTNALR
110 120 130 140 150
RGVRYFTALQ ASDGHWPGEI TGPLFFLPPL IFCLYITGHL EEVFDAEHRK
160 170 180 190 200
EMLRHIYCHQ NEDGGWGLHI ESKSVMFCTV LNYICLRMLG ENPEQDACKR
210 220 230 240 250
ARQWILDRGG VIFIPSWGKF WLSILGVYDW SGTNPTPPEL LMLPSFLPIH
260 270 280 290 300
PGKILCYSRM VSIPMSYLYG KRFVGPITPL ILLLREELYL EPYEEINWKK
310 320 330 340 350
SRRLYAKEDM YYAHPLVQDL LSDTLQNFVE PLLTRWPLNK LVREKALQLT
360 370 380 390 400
MKHIHYEDEN SHYITIGCVE KVLCMLACWV ENPNGDYFKK HLARIPDYMW
410 420 430 440 450
VAEDGMKMQS FGCQLWDTGF AIQALLASNL PDETDDALKR GHNYIKASQV
460 470 480 490 500
RENPSGDFRS MYRHISKGAW TFSDRDHGWQ VSDCTAEALK CCLLLSMMSA
510 520 530 540 550
DIVGQKIDDE QLYDSVNLLL SLQSGNGGVN AWEPSRAYKW LELLNPTEFM
560 570 580 590 600
ANTMVEREFV ECTSSVIQAL DLFRKLYPDH RKKEINRSIE KAVQFIQDNQ
610 620 630 640 650
TPDGSWYGNW GVCFIYATWF ALGGLAAAGE TYNDCLAMRN GVHFLLTTQR
660 670 680 690 700
DDGGWGESYL SCSEQRYIPS EGERSNLVQT SWAMMALIHT GQAERDLIPL
710 720 730 740 750
HRAAKLIINS QLENGDFPQQ EIVGAFMNTC MLHYATYRNT FPLWALAEYR

KVVFIVN
Length:757
Mass (Da):87,352
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98C1C0C30D7975D5
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC17055 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti466S → W in AAB94341 (PubMed:11247608).Curated1
Sequence conflicti503V → G in AAD05032 (PubMed:9883589).Curated1
Sequence conflicti698I → T in AAD05032 (PubMed:9883589).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U49919 mRNA Translation: AAD05032.1
U87266 mRNA Translation: AAB94341.1
AC002986 Genomic DNA Translation: AAC17055.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE36186.1
CP002684 Genomic DNA Translation: AEE36187.1
CP002684 Genomic DNA Translation: ANM58606.1
AF360147 mRNA Translation: AAK25857.1
AY052358 mRNA Translation: AAK96549.1
AY142678 mRNA Translation: AAN13216.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T01058

NCBI Reference Sequences

More...
RefSeqi
NP_001321029.1, NM_001334865.1
NP_178018.1, NM_106546.3
NP_849903.1, NM_179572.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G78970.1; AT1G78970.1; AT1G78970
AT1G78970.2; AT1G78970.2; AT1G78970
AT1G78970.3; AT1G78970.3; AT1G78970

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
844237

Gramene; a comparative resource for plants

More...
Gramenei
AT1G78970.1; AT1G78970.1; AT1G78970
AT1G78970.2; AT1G78970.2; AT1G78970
AT1G78970.3; AT1G78970.3; AT1G78970

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G78970

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49919 mRNA Translation: AAD05032.1
U87266 mRNA Translation: AAB94341.1
AC002986 Genomic DNA Translation: AAC17055.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE36186.1
CP002684 Genomic DNA Translation: AEE36187.1
CP002684 Genomic DNA Translation: ANM58606.1
AF360147 mRNA Translation: AAK25857.1
AY052358 mRNA Translation: AAK96549.1
AY142678 mRNA Translation: AAN13216.1
PIRiT01058
RefSeqiNP_001321029.1, NM_001334865.1
NP_178018.1, NM_106546.3
NP_849903.1, NM_179572.2

3D structure databases

SMRiQ9C5M3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi29456, 2 interactors
IntActiQ9C5M3, 1 interactor
STRINGi3702.AT1G78970.1

Proteomic databases

PaxDbiQ9C5M3

Genome annotation databases

EnsemblPlantsiAT1G78970.1; AT1G78970.1; AT1G78970
AT1G78970.2; AT1G78970.2; AT1G78970
AT1G78970.3; AT1G78970.3; AT1G78970
GeneIDi844237
GrameneiAT1G78970.1; AT1G78970.1; AT1G78970
AT1G78970.2; AT1G78970.2; AT1G78970
AT1G78970.3; AT1G78970.3; AT1G78970
KEGGiath:AT1G78970

Organism-specific databases

AraportiAT1G78970
TAIRilocus:2207310 AT1G78970

Phylogenomic databases

eggNOGiKOG0497 Eukaryota
COG1657 LUCA
HOGENOMiHOG000234317
InParanoidiQ9C5M3
KOiK15816
OMAiEFMANTM
OrthoDBi365003at2759
PhylomeDBiQ9C5M3

Enzyme and pathway databases

BioCyciARA:GQT-1793-MONOMER
BRENDAi4.2.1.128 399
5.4.99.41 399

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9C5M3

Gene expression databases

ExpressionAtlasiQ9C5M3 baseline and differential
GenevisibleiQ9C5M3 AT

Family and domain databases

CDDicd02892 SQCY_1, 1 hit
InterProiView protein in InterPro
IPR032696 SQ_cyclase_C
IPR032697 SQ_cyclase_N
IPR018333 Squalene_cyclase
IPR002365 Terpene_synthase_CS
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF13243 SQHop_cyclase_C, 1 hit
PF13249 SQHop_cyclase_N, 1 hit
SUPFAMiSSF48239 SSF48239, 2 hits
TIGRFAMsiTIGR01787 squalene_cyclas, 1 hit
PROSITEiView protein in PROSITE
PS01074 TERPENE_SYNTHASES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLUP1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C5M3
Secondary accession number(s): O49985, O64551, P92977
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2001
Last modified: December 11, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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