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Entry version 101 (18 Sep 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Gamma-tubulin complex component 2

Gene

GCP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the microtubule organizing centers (MTOCs). Required for the positioning of the gamma-tubulin-containing complex on pre-existing microtubules and for the proper organization of cortical arrays.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-tubulin complex component 2
Short name:
AtGCP2
Short name:
GCP-2
Alternative name(s):
Protein SPIRAL 3
Spindle pole body protein Spc97 homolog
Short name:
AtSpc97
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GCP2
Synonyms:SPC97, SPR3
Ordered Locus Names:At5g17410
ORF Names:T10B6.70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G17410

The Arabidopsis Information Resource

More...
TAIRi
locus:2178930 AT5G17410

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality. Impaired development of male and female gametophytes.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi305G → R in spr3; right-handed helical growth due to anisotropic cell expansion and abnormal microtubule branching characterized by wider and divergently distributed nucleating angles. Impaired interaction with GCP3. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004289691 – 678Gamma-tubulin complex component 2Add BLAST678

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C5H9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C5H9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C5H9 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the gamma-tubulin complex. Gamma-tubulin complex is composed of gamma-tubulin and GCP proteins (e.g. GCP2 and GCP3).

Interacts directly with GCP3.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
16883, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9C5H9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT5G17410.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9C5H9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni63 – 116Triggers nucleus envelope localizationAdd BLAST54
Regioni118 – 180Triggers nucleus envelope localizationAdd BLAST63
Regioni290 – 318Triggers nucleus envelope localizationAdd BLAST29
Regioni472 – 548Triggers nucleus envelope localizationAdd BLAST77
Regioni587 – 622Triggers nucleus envelope localizationAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2001 Eukaryota
ENOG410XNRE LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000030677

KEGG Orthology (KO)

More...
KOi
K16569

Identification of Orthologs from Complete Genome Data

More...
OMAi
LEHGTML

Database of Orthologous Groups

More...
OrthoDBi
679187at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C5H9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.1900, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007259 GCP
IPR040457 GCP_C
IPR042241 GCP_C_sf
IPR041470 GCP_N

The PANTHER Classification System

More...
PANTHERi
PTHR19302 PTHR19302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04130 GCP_C_terminal, 1 hit
PF17681 GCP_N_terminal, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9C5H9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESMTPISCP TTPRWNQDRP FLTGRFHQET RASSKFADSK RFTLDSSSSG
60 70 80 90 100
VEQAIGCYDT PVQELIVIDD LLSALVGIEG RYISIKRFHG KEDSIAFQVD
110 120 130 140 150
PSMDLALQEL AKRIFPLCEY YLLIDQFVES SSQFKNGLVN HAFAAALRAL
160 170 180 190 200
LLDYQAMVAQ LEHQFRLGRL SIQGLWFYCQ PMMGSMRALA AVIQQASTKQ
210 220 230 240 250
FVGSGVLNLL QSQAKAMAGD NSVRSLLEKM TECASNAYLS ILERWVYEGI
260 270 280 290 300
IDDPYGEFFI AENRSLKKES LSQDSTAKYW SQRYSLKDTI PGFLANIAAT
310 320 330 340 350
ILTTGKYLNV MRECGHNVQV PISERSKLTI FGSNHHYLEC IKAAHEFASI
360 370 380 390 400
ELVNLIKDKY DLVGRLRSIK HYLLLDQGDF LVHFMDIARE ELNKKVHEIS
410 420 430 440 450
VEKLQSLLDL ALRTTAAAAD PRHEDLTCCV DRASLLTTLG MHKDTDSNSI
460 470 480 490 500
EDPMSITGLE TFSLSYKVQW PLSIVISKKA LSKYQLIFRF LFHCKHVERQ
510 520 530 540 550
LCGAWQIHQG IRSMNSKGTA ILRSSLLCRS MLKFISSLLH YLTFEVLEPN
560 570 580 590 600
WHVMHDRLQS TRSVDEVIQH HDFFLDKCLR GCLLLLPDVL KKMEKLKSVC
610 620 630 640 650
LQYAAATQWL ISSSIDINSQ SHPQKTMIRD TTVTESIFNF EREFNSELQS
660 670
LGPVLSKGSQ AEPYLTHLSQ WILGVSKE
Length:678
Mass (Da):76,946
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02D4392BFA8B0ADA
GO
Isoform 2 (identifier: Q9C5H9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-45: D → DS

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:679
Mass (Da):77,033
Checksum:i2F21579ED5D95E7F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAC01736 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05453645D → DS in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL391142 Genomic DNA Translation: CAC01736.1 Sequence problems.
CP002688 Genomic DNA Translation: AED92422.1
CP002688 Genomic DNA Translation: AED92423.1
AF360238 mRNA Translation: AAK25948.1
AY040037 mRNA Translation: AAK64095.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T51578

NCBI Reference Sequences

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RefSeqi
NP_568346.1, NM_121747.4 [Q9C5H9-1]
NP_850838.1, NM_180507.2 [Q9C5H9-2]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G17410.1; AT5G17410.1; AT5G17410 [Q9C5H9-1]
AT5G17410.2; AT5G17410.2; AT5G17410 [Q9C5H9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
831607

Gramene; a comparative resource for plants

More...
Gramenei
AT5G17410.1; AT5G17410.1; AT5G17410 [Q9C5H9-1]
AT5G17410.2; AT5G17410.2; AT5G17410 [Q9C5H9-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G17410

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391142 Genomic DNA Translation: CAC01736.1 Sequence problems.
CP002688 Genomic DNA Translation: AED92422.1
CP002688 Genomic DNA Translation: AED92423.1
AF360238 mRNA Translation: AAK25948.1
AY040037 mRNA Translation: AAK64095.1
PIRiT51578
RefSeqiNP_568346.1, NM_121747.4 [Q9C5H9-1]
NP_850838.1, NM_180507.2 [Q9C5H9-2]

3D structure databases

SMRiQ9C5H9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi16883, 1 interactor
IntActiQ9C5H9, 1 interactor
STRINGi3702.AT5G17410.2

Proteomic databases

PaxDbiQ9C5H9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G17410.1; AT5G17410.1; AT5G17410 [Q9C5H9-1]
AT5G17410.2; AT5G17410.2; AT5G17410 [Q9C5H9-2]
GeneIDi831607
GrameneiAT5G17410.1; AT5G17410.1; AT5G17410 [Q9C5H9-1]
AT5G17410.2; AT5G17410.2; AT5G17410 [Q9C5H9-2]
KEGGiath:AT5G17410

Organism-specific databases

AraportiAT5G17410
TAIRilocus:2178930 AT5G17410

Phylogenomic databases

eggNOGiKOG2001 Eukaryota
ENOG410XNRE LUCA
HOGENOMiHOG000030677
KOiK16569
OMAiLEHGTML
OrthoDBi679187at2759
PhylomeDBiQ9C5H9

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9C5H9

Gene expression databases

ExpressionAtlasiQ9C5H9 baseline and differential
GenevisibleiQ9C5H9 AT

Family and domain databases

Gene3Di1.20.120.1900, 1 hit
InterProiView protein in InterPro
IPR007259 GCP
IPR040457 GCP_C
IPR042241 GCP_C_sf
IPR041470 GCP_N
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 GCP_C_terminal, 1 hit
PF17681 GCP_N_terminal, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGACP2_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C5H9
Secondary accession number(s): F4KGZ8, Q9LF43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 14, 2014
Last sequence update: June 1, 2001
Last modified: September 18, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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