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Entry version 125 (08 May 2019)
Sequence version 1 (01 Jun 2001)
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Protein

F-box/LRR-repeat protein 4

Gene

FBL4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box/LRR-repeat protein 4
Short name:
AtFBL4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBL4
Ordered Locus Names:At4g15475
ORF Names:dl3775w, FCAALL.58
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G15475

The Arabidopsis Information Resource

More...
TAIRi
locus:505006471 AT4G15475

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003651721 – 610F-box/LRR-repeat protein 4Add BLAST610

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C5D2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C5D2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C5D2 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT4G15475.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 52F-boxAdd BLAST48
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati53 – 79LRR 1Add BLAST27
Repeati124 – 149LRR 2Add BLAST26
Repeati150 – 175LRR 3Add BLAST26
Repeati178 – 200LRR 4Add BLAST23
Repeati201 – 227LRR 5Add BLAST27
Repeati228 – 253LRR 6Add BLAST26
Repeati256 – 277LRR 7Add BLAST22
Repeati278 – 303LRR 8Add BLAST26
Repeati304 – 329LRR 9Add BLAST26
Repeati330 – 355LRR 10Add BLAST26
Repeati356 – 381LRR 11Add BLAST26
Repeati382 – 407LRR 12Add BLAST26
Repeati408 – 433LRR 13Add BLAST26
Repeati434 – 459LRR 14Add BLAST26
Repeati460 – 484LRR 15Add BLAST25
Repeati485 – 510LRR 16Add BLAST26
Repeati511 – 536LRR 17Add BLAST26
Repeati537 – 562LRR 18Add BLAST26
Repeati563 – 588LRR 19Add BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1947 Eukaryota
ENOG410XQ54 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000243338

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C5D2

KEGG Orthology (KO)

More...
KOi
K10268

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPEVTDV

Database of Orthologous Groups

More...
OrthoDBi
1282076at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C5D2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041567 COI1_F-box
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18511 F-box_5, 1 hit
PF13516 LRR_6, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81383 SSF81383, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9C5D2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGHDRINNC LPEELILEIF RRLESKPNRD ACSLVCKRWL SLERFSRTTL
60 70 80 90 100
RIGASFSPDD FISLLSRRFL YITSIHVDER ISVSLPSLSP SPKRKRGRDS
110 120 130 140 150
SSPSSSKRKK LTDKTHSGAE NVESSSLTDT GLTALANGFP RIENLSLIWC
160 170 180 190 200
PNVSSVGLCS LAQKCTSLKS LDLQGCYVGD QGLAAVGKFC KQLEELNLRF
210 220 230 240 250
CEGLTDVGVI DLVVGCSKSL KSIGVAASAK ITDLSLEAVG SHCKLLEVLY
260 270 280 290 300
LDSEYIHDKG LIAVAQGCHR LKNLKLQCVS VTDVAFAAVG ELCTSLERLA
310 320 330 340 350
LYSFQHFTDK GMRAIGKGSK KLKDLTLSDC YFVSCKGLEA IAHGCKELER
360 370 380 390 400
VEINGCHNIG TRGIEAIGKS CPRLKELALL YCQRIGNSAL QEIGKGCKSL
410 420 430 440 450
EILHLVDCSG IGDIAMCSIA KGCRNLKKLH IRRCYEIGNK GIISIGKHCK
460 470 480 490 500
SLTELSLRFC DKVGNKALIA IGKGCSLQQL NVSGCNQISD AGITAIARGC
510 520 530 540 550
PQLTHLDISV LQNIGDMPLA ELGEGCPMLK DLVLSHCHHI TDNGLNHLVQ
560 570 580 590 600
KCKLLETCHM VYCPGITSAG VATVVSSCPH IKKVLIEKWK VTERTTRRAG
610
SVISYLCMDL
Length:610
Mass (Da):66,422
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A165F930CBB69CA
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB10325 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g15470 has been split into 2 genes: At4g15470 and At4g15475.Curated
The sequence CAB78589 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g15470 has been split into 2 genes: At4g15470 and At4g15475.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71Y → H in AAM60829 (Ref. 5) Curated1
Sequence conflicti116H → Q in AAM60829 (Ref. 5) Curated1
Sequence conflicti137N → D in AAM60829 (Ref. 5) Curated1
Sequence conflicti213V → A in AAM60829 (Ref. 5) Curated1
Sequence conflicti269H → N in AAM60829 (Ref. 5) Curated1
Sequence conflicti463V → I in AAM60829 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z97339 Genomic DNA Translation: CAB10325.1 Sequence problems.
AL161541 Genomic DNA Translation: CAB78589.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83608.1
AF360328 mRNA Translation: AAK26038.1
AF361808 mRNA Translation: AAK32821.1
AY056338 mRNA Translation: AAL07187.1
AY084229 mRNA Translation: AAM60829.1

NCBI Reference Sequences

More...
RefSeqi
NP_567467.1, NM_117637.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G15475.1; AT4G15475.1; AT4G15475

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
827219

Gramene; a comparative resource for plants

More...
Gramenei
AT4G15475.1; AT4G15475.1; AT4G15475

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G15475

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97339 Genomic DNA Translation: CAB10325.1 Sequence problems.
AL161541 Genomic DNA Translation: CAB78589.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83608.1
AF360328 mRNA Translation: AAK26038.1
AF361808 mRNA Translation: AAK32821.1
AY056338 mRNA Translation: AAL07187.1
AY084229 mRNA Translation: AAM60829.1
RefSeqiNP_567467.1, NM_117637.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT4G15475.1

Proteomic databases

PaxDbiQ9C5D2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G15475.1; AT4G15475.1; AT4G15475
GeneIDi827219
GrameneiAT4G15475.1; AT4G15475.1; AT4G15475
KEGGiath:AT4G15475

Organism-specific databases

AraportiAT4G15475
TAIRilocus:505006471 AT4G15475

Phylogenomic databases

eggNOGiKOG1947 Eukaryota
ENOG410XQ54 LUCA
HOGENOMiHOG000243338
InParanoidiQ9C5D2
KOiK10268
OMAiCPEVTDV
OrthoDBi1282076at2759
PhylomeDBiQ9C5D2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9C5D2

Gene expression databases

ExpressionAtlasiQ9C5D2 baseline and differential
GenevisibleiQ9C5D2 AT

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR041567 COI1_F-box
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF18511 F-box_5, 1 hit
PF13516 LRR_6, 6 hits
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 17 hits
SUPFAMiSSF81383 SSF81383, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBL4_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C5D2
Secondary accession number(s): O23399, Q8LGK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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