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Protein

Protein ATAF2

Gene

NAC081

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in disease resistance response (PubMed:16115070, PubMed:19625399). May function as repressor of pathogenesis-related proteins (PubMed:16115070). May function in the regulation of host basal defense responses against viral infection (PubMed:19625399). Transcriptional activator involved in responses to wounding and infection with tobamovirus (TMV) (PubMed:22937923). Binds to the DNA sequences 5'-AAAATATCT-3' and 5'AGATTTTT-3' of CYP734A1/BAS1 and CYP72C1/SOB7 promoters, respectively. Acts as suppressor of the brassinosteroid (BR)-inactivating enzymes CYP734A1/BAS1 and CYP72C1/SOB7, and prevents their expression in almost all tissues. Plays a central role in integrating BR homeostasis and seedling development. Regulates the spatial regulation of BR homeostasis and participates in the regulation of hypocotyl elongation and root growth by suppressing BR catabolism. Mediates connection between BR catabolism and photomorphogenesis (PubMed:26493403). Binds to, and transactivates the promoter of the auxin biosynthetic gene NIT2 (PubMed:22965747). Stress-responsive NAC transcription factor involved in ABA-inducible leaf senescence signaling (PubMed:26518251). Required for normal seed development and morphology (PubMed:18849494).7 Publications

Miscellaneous

Plants over-expressing NAC081 show enhanced susceptibility to the necrotrophic fungal pathogen Fusarium oxysporum (PubMed:16115070). Plants over-expressing NAC081 exhibit abnormal developmental phenotypes such as dwarfism and leaf-yellowing (PubMed:22965747). Plants silencing NAC081 produce abnormally shaped seeds (PubMed:18849494).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi103 – 165PROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • protein histidine kinase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processHost-virus interaction, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ATAF2
Alternative name(s):
NAC domain-containing protein 81
Short name:
ANAC081
Gene namesi
Name:NAC081
Synonyms:ATAF2
Ordered Locus Names:At5g08790
ORF Names:T2K12.140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G08790
TAIRilocus:504956335 AT5G08790

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Reduced sensitivity to indole-3-acetonitrile.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986011 – 283Protein ATAF2Add BLAST283

Proteomic databases

PaxDbiQ9C598

Expressioni

Tissue specificityi

Expressed in roots, cotyledons, rosette leaves, cauline leaves and mature flowers. Expressed at low levels in stems and flower buds.1 Publication

Inductioni

Induced by wounding, salicylic acid (SA), methyl jasmonate, drought stress, dark and sucrose starvation (PubMed:16115070). Induced by chitin elicitor (chitooctaose) (PubMed:17722694). Induced by salicylic acid and infection with tobamovirus (TMV) (PubMed:19625399). By indole-3-acetonitrile, salicylic acid (SA), sodium nitroprusside (SNP), salt stress and drought stress (PubMed:22965747). Down-regulated by brassinosteroid (BR) and transition from dark to white light (PubMed:26493403).5 Publications

Gene expression databases

ExpressionAtlasiQ9C598 baseline and differential

Interactioni

Subunit structurei

Homodimer (PubMed:22937923). Interacts with AHK2 (PubMed:18642946). Interacts with AHL12 and AHL27 (PubMed:24218605). Interacts with the helicase domain of the tobamovirus (TMV) replicase (PubMed:19625399).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BHLH68Q8S3D13EBI-1998565,EBI-15192111

GO - Molecular functioni

Protein-protein interaction databases

BioGridi16057, 6 interactors
IntActiQ9C598, 19 interactors
STRINGi3702.AT5G08790.1

Structurei

3D structure databases

ProteinModelPortaliQ9C598
SMRiQ9C598
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 159NACPROSITE-ProRule annotationAdd BLAST153

Domaini

The NAC domain includes a DNA-binding domain and a dimerization domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410JU4I Eukaryota
ENOG411077U LUCA
HOGENOMiHOG000237406
InParanoidiQ9C598
OMAiKPRTTTM
OrthoDBiEOG09360B83
PhylomeDBiQ9C598

Family and domain databases

Gene3Di3.30.310.150, 1 hit
InterProiView protein in InterPro
IPR003441 NAC-dom
IPR036093 NAC_dom_sf
PfamiView protein in Pfam
PF02365 NAM, 1 hit
SUPFAMiSSF101941 SSF101941, 1 hit
PROSITEiView protein in PROSITE
PS51005 NAC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9C598-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSELNLPAG FRFHPTDEEL VKFYLCRKCA SEQISAPVIA EIDLYKFNPW
60 70 80 90 100
ELPEMSLYGE KEWYFFSPRD RKYPNGSRPN RAAGTGYWKA TGADKPIGKP
110 120 130 140 150
KTLGIKKALV FYAGKAPKGI KTNWIMHEYR LANVDRSASV NKKNNLRLDD
160 170 180 190 200
WVLCRIYNKK GTMEKYFPAD EKPRTTTMAE QSSSPFDTSD STYPTLQEDD
210 220 230 240 250
SSSSGGHGHV VSPDVLEVQS EPKWGELEDA LEAFDTSMFG SSMELLQPDA
260 270 280
FVPQFLYQSD YFTSFQDPPE QKPFLNWSFA PQG
Length:283
Mass (Da):32,225
Last modified:June 1, 2001 - v1
Checksum:i0EA26ADF23B94A7C
GO
Isoform 2 (identifier: Q9C598-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-153: LDDWVL → VSSVSY
     154-283: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:153
Mass (Da):17,499
Checksum:i440C05B525F87926
GO

Sequence cautioni

The sequence CAA52772 differs from that shown. Reason: Frameshift at position 239.Curated
The sequence CAA52772 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039771148 – 153LDDWVL → VSSVSY in isoform 2. 1 Publication6
Alternative sequenceiVSP_039772154 – 283Missing in isoform 2. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74756 mRNA Translation: CAA52772.1 Sequence problems.
AL590346 Genomic DNA Translation: CAC35884.1
CP002688 Genomic DNA Translation: AED91350.1
AK118910 mRNA Translation: BAC43493.1
AY080862 mRNA Translation: AAL87335.1
AY133762 mRNA Translation: AAM91696.1
AK228803 mRNA Translation: BAF00699.1
PIRiS37100
RefSeqiNP_680161.1, NM_147856.4 [Q9C598-1]
UniGeneiAt.27826
At.71069

Genome annotation databases

EnsemblPlantsiAT5G08790.1; AT5G08790.1; AT5G08790 [Q9C598-1]
GeneIDi830779
GrameneiAT5G08790.1; AT5G08790.1; AT5G08790 [Q9C598-1]
KEGGiath:AT5G08790

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74756 mRNA Translation: CAA52772.1 Sequence problems.
AL590346 Genomic DNA Translation: CAC35884.1
CP002688 Genomic DNA Translation: AED91350.1
AK118910 mRNA Translation: BAC43493.1
AY080862 mRNA Translation: AAL87335.1
AY133762 mRNA Translation: AAM91696.1
AK228803 mRNA Translation: BAF00699.1
PIRiS37100
RefSeqiNP_680161.1, NM_147856.4 [Q9C598-1]
UniGeneiAt.27826
At.71069

3D structure databases

ProteinModelPortaliQ9C598
SMRiQ9C598
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16057, 6 interactors
IntActiQ9C598, 19 interactors
STRINGi3702.AT5G08790.1

Proteomic databases

PaxDbiQ9C598

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G08790.1; AT5G08790.1; AT5G08790 [Q9C598-1]
GeneIDi830779
GrameneiAT5G08790.1; AT5G08790.1; AT5G08790 [Q9C598-1]
KEGGiath:AT5G08790

Organism-specific databases

AraportiAT5G08790
TAIRilocus:504956335 AT5G08790

Phylogenomic databases

eggNOGiENOG410JU4I Eukaryota
ENOG411077U LUCA
HOGENOMiHOG000237406
InParanoidiQ9C598
OMAiKPRTTTM
OrthoDBiEOG09360B83
PhylomeDBiQ9C598

Miscellaneous databases

PROiPR:Q9C598

Gene expression databases

ExpressionAtlasiQ9C598 baseline and differential

Family and domain databases

Gene3Di3.30.310.150, 1 hit
InterProiView protein in InterPro
IPR003441 NAC-dom
IPR036093 NAC_dom_sf
PfamiView protein in Pfam
PF02365 NAM, 1 hit
SUPFAMiSSF101941 SSF101941, 1 hit
PROSITEiView protein in PROSITE
PS51005 NAC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNAC81_ARATH
AccessioniPrimary (citable) accession number: Q9C598
Secondary accession number(s): Q38968, Q8GWD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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