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Protein

N-acetylglucosamine-6-phosphate deacetylase

Gene

CaNAG2

Organism
Candida albicans (Yeast)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi140Divalent metal cationUniRule annotation1
Binding sitei151Substrate; via amide nitrogenUniRule annotation1
Metal bindingi208Divalent metal cation; via tele nitrogenUniRule annotation1
Metal bindingi229Divalent metal cation; via tele nitrogenUniRule annotation1
Binding sitei240SubstrateUniRule annotation1
Binding sitei266Substrate; via tele nitrogenUniRule annotation1
Active sitei288Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processCarbohydrate metabolismUniRule annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosamine-6-phosphate deacetylaseUniRule annotation (EC:3.5.1.25UniRule annotation)
Gene namesi
Name:CaNAG2Imported
Synonyms:DAC1Imported
OrganismiCandida albicans (Yeast)Imported
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Structurei

3D structure databases

ProteinModelPortaliQ9C0N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 394Amidohydro-relInterPro annotationAdd BLAST343

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni232 – 233Substrate bindingUniRule annotation2
Regioni322 – 324Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. NagA family.UniRule annotation

Family and domain databases

CDDicd00854 NagA, 1 hit
Gene3Di2.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR003764 GlcNAc_6-P_deAcase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PIRSFiPIRSF038994 NagA, 1 hit
SUPFAMiSSF51338 SSF51338, 1 hit
SSF51556 SSF51556, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C0N5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFTRFTNCH LIDNGELYEF TDLYVNNATK RICHPPANPE LVSEVIDLKQ
60 70 80 90 100
QILAPGFIDI QNNGIYGLNF SNLGEESTAE DVAEFKRFYR DAMAKYLSTG
110 120 130 140 150
VTATCPTVTS SFPEVYAKVL PMYKRSVLAS QTDSLGAHVE GPFINVQKKG
160 170 180 190 200
CHPVETFVDA KEGESKLLEV YGDLFDNVCI VTAAPEIAGV LDLIPVVKSK
210 220 230 240 250
NCVFSIGHTM SDYDTAVKAV EKGATMITHL YNAMPQPHHR NAGVVGLINS
260 270 280 290 300
PIVDTPYFGL ICDGVHVDPS MANLAYRSNP SKCVLVTDAM HLIGLPDGHY
310 320 330 340 350
KWDSQVIVKT GDRLYLENTD TLAGAATTLP QCVRNLVKWS QISLPQAVMT
360 370 380 390 400
VTNNAAKSIG VDHERGFLNV GCLADFVVLD KSGFVRKVYK LGREVQSSDI
410
PLDRATDKLT AVL
Length:413
Mass (Da):45,198
Last modified:June 1, 2001 - v1
Checksum:iC77C52230675FA29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KP165331 Genomic DNA Translation: AJW76789.1
AB052107 Genomic DNA Translation: BAB43813.1
AB056468 Genomic DNA Translation: BAB43820.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KP165331 Genomic DNA Translation: AJW76789.1
AB052107 Genomic DNA Translation: BAB43813.1
AB056468 Genomic DNA Translation: BAB43820.1

3D structure databases

ProteinModelPortaliQ9C0N5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00854 NagA, 1 hit
Gene3Di2.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR003764 GlcNAc_6-P_deAcase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PIRSFiPIRSF038994 NagA, 1 hit
SUPFAMiSSF51338 SSF51338, 1 hit
SSF51556 SSF51556, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9C0N5_CANAX
AccessioniPrimary (citable) accession number: Q9C0N5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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