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Protein

STE20-related kinase adapter protein beta

Gene

STRADB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).By similarity1 Publication

Caution

Ser-184 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei89ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi64 – 72ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9C0K7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
STE20-related kinase adapter protein beta
Short name:
STRAD beta
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein
CALS-21
ILP-interacting protein
Pseudokinase ALS2CR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STRADB
Synonyms:ALS2CR2, ILPIP
ORF Names:PRO1038
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000082146.12

Human Gene Nomenclature Database

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HGNCi
HGNC:13205 STRADB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607333 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0K7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000082146

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24743

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STRADB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762722

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000856171 – 418STE20-related kinase adapter protein betaAdd BLAST418

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9C0K7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9C0K7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C0K7

PeptideAtlas

More...
PeptideAtlasi
Q9C0K7

PRoteomics IDEntifications database

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PRIDEi
Q9C0K7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80073
80074 [Q9C0K7-2]
80075 [Q9C0K7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0K7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0K7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, skeletal muscle, testis, liver and colon.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000082146 Expressed in 92 organ(s), highest expression level in right adrenal gland cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_STRADB

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C0K7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C0K7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026549
HPA028520

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120668, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q9C0K7, 5 interactors

Molecular INTeraction database

More...
MINTi
Q9C0K7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000194530

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9C0K7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9C0K7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 369Protein kinasePROSITE-ProRule annotationAdd BLAST312

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain is predicted to be catalytically inactive.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0582 Eukaryota
ENOG410XSWS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155390

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000005157

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG055069

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0K7

KEGG Orthology (KO)

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KOi
K17532

Identification of Orthologs from Complete Genome Data

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OMAi
DCSCILR

Database of Orthologous Groups

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OrthoDBi
995563at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C0K7

TreeFam database of animal gene trees

More...
TreeFami
TF319817

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9C0K7-1) [UniParc]FASTAAdd to basket
Also known as: ILPIP-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLLDCFCTS RTQVESLRPE KQSETSIHQY LVDEPTLSWS RPSTRASEVL
60 70 80 90 100
CSTNVSHYEL QVEIGRGFDN LTSVHLARHT PTGTLVTIKI TNLENCNEER
110 120 130 140 150
LKALQKAVIL SHFFRHPNIT TYWTVFTVGS WLWVISPFMA YGSASQLLRT
160 170 180 190 200
YFPEGMSETL IRNILFGAVR GLNYLHQNGC IHRSIKASHI LISGDGLVTL
210 220 230 240 250
SGLSHLHSLV KHGQRHRAVY DFPQFSTSVQ PWLSPELLRQ DLHGYNVKSD
260 270 280 290 300
IYSVGITACE LASGQVPFQD MHRTQMLLQK LKGPPYSPLD ISIFPQSESR
310 320 330 340 350
MKNSQSGVDS GIGESVLVSS GTHTVNSDRL HTPSSKTFSP AFFSLVQLCL
360 370 380 390 400
QQDPEKRPSA SSLLSHVFFK QMKEESQDSI LSLLPPAYNK PSISLPPVLP
410
WTEPECDFPD EKDSYWEF
Length:418
Mass (Da):47,026
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA63ED6CCE1E18C96
GO
Isoform 2 (identifier: Q9C0K7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     372-377: MKEESQ → PYFEFL
     378-418: Missing.

Note: No experimental confirmation available.
Show »
Length:377
Mass (Da):42,371
Checksum:iC869F81FDED0839A
GO
Isoform 3 (identifier: Q9C0K7-3) [UniParc]FASTAAdd to basket
Also known as: ILPIP-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:280
Mass (Da):31,219
Checksum:i9D433EAA77D5CF08
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JSU7C9JSU7_HUMAN
STE20-related kinase adapter protei...
STRADB
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3S5H7C3S5_HUMAN
STE20-related kinase adapter protei...
STRADB
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCQ7F8WCQ7_HUMAN
STE20-related kinase adapter protei...
STRADB
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041335155G → E in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041336386P → L1 PublicationCorresponds to variant dbSNP:rs35636836Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0166251 – 138Missing in isoform 3. 2 PublicationsAdd BLAST138
Alternative sequenceiVSP_016623372 – 377MKEESQ → PYFEFL in isoform 2. 1 Publication6
Alternative sequenceiVSP_016624378 – 418Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB038950 mRNA Translation: BAB32500.1
AY093697 mRNA Translation: AAM19143.1
AF116618 mRNA Translation: AAF71042.1
AK027637 mRNA Translation: BAB55254.1
AC007282 Genomic DNA Translation: AAY14692.1
BC008302 mRNA Translation: AAH08302.1
BC090871 mRNA Translation: AAH90871.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2348.1 [Q9C0K7-1]
CCDS56161.1 [Q9C0K7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001193793.1, NM_001206864.1 [Q9C0K7-2]
NP_061041.2, NM_018571.5 [Q9C0K7-1]
XP_016859927.1, XM_017004438.1 [Q9C0K7-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.652338

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000194530; ENSP00000194530; ENSG00000082146 [Q9C0K7-1]
ENST00000392249; ENSP00000376080; ENSG00000082146 [Q9C0K7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55437

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55437

UCSC genome browser

More...
UCSCi
uc002uyd.5 human [Q9C0K7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038950 mRNA Translation: BAB32500.1
AY093697 mRNA Translation: AAM19143.1
AF116618 mRNA Translation: AAF71042.1
AK027637 mRNA Translation: BAB55254.1
AC007282 Genomic DNA Translation: AAY14692.1
BC008302 mRNA Translation: AAH08302.1
BC090871 mRNA Translation: AAH90871.1
CCDSiCCDS2348.1 [Q9C0K7-1]
CCDS56161.1 [Q9C0K7-2]
RefSeqiNP_001193793.1, NM_001206864.1 [Q9C0K7-2]
NP_061041.2, NM_018571.5 [Q9C0K7-1]
XP_016859927.1, XM_017004438.1 [Q9C0K7-3]
UniGeneiHs.652338

3D structure databases

ProteinModelPortaliQ9C0K7
SMRiQ9C0K7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120668, 17 interactors
IntActiQ9C0K7, 5 interactors
MINTiQ9C0K7
STRINGi9606.ENSP00000194530

PTM databases

iPTMnetiQ9C0K7
PhosphoSitePlusiQ9C0K7

Polymorphism and mutation databases

BioMutaiSTRADB
DMDMi74762722

Proteomic databases

EPDiQ9C0K7
jPOSTiQ9C0K7
PaxDbiQ9C0K7
PeptideAtlasiQ9C0K7
PRIDEiQ9C0K7
ProteomicsDBi80073
80074 [Q9C0K7-2]
80075 [Q9C0K7-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55437
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000194530; ENSP00000194530; ENSG00000082146 [Q9C0K7-1]
ENST00000392249; ENSP00000376080; ENSG00000082146 [Q9C0K7-2]
GeneIDi55437
KEGGihsa:55437
UCSCiuc002uyd.5 human [Q9C0K7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55437
EuPathDBiHostDB:ENSG00000082146.12

GeneCards: human genes, protein and diseases

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GeneCardsi
STRADB
HGNCiHGNC:13205 STRADB
HPAiHPA026549
HPA028520
MIMi607333 gene
neXtProtiNX_Q9C0K7
OpenTargetsiENSG00000082146
PharmGKBiPA24743

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0582 Eukaryota
ENOG410XSWS LUCA
GeneTreeiENSGT00940000155390
HOGENOMiHOG000005157
HOVERGENiHBG055069
InParanoidiQ9C0K7
KOiK17532
OMAiDCSCILR
OrthoDBi995563at2759
PhylomeDBiQ9C0K7
TreeFamiTF319817

Enzyme and pathway databases

ReactomeiR-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
SignaLinkiQ9C0K7

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ALS2CR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55437

Protein Ontology

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PROi
PR:Q9C0K7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000082146 Expressed in 92 organ(s), highest expression level in right adrenal gland cortex
CleanExiHS_STRADB
ExpressionAtlasiQ9C0K7 baseline and differential
GenevisibleiQ9C0K7 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTRAB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0K7
Secondary accession number(s): Q5BKY7, Q9P1L0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: January 16, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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Main funding by: National Institutes of Health

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