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Protein

Actin-related protein 3C

Gene

ACTR3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9C0K3

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 3C
Alternative name(s):
Actin-related protein 11
Gene namesi
Name:ACTR3C
Synonyms:ARP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106526.10
HGNCiHGNC:37282 ACTR3C
neXtProtiNX_Q9C0K3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106526
PharmGKBiPA165617588

Polymorphism and mutation databases

BioMutaiACTR3C
DMDMi74739414

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000032433322 – 210Actin-related protein 3CAdd BLAST189

Proteomic databases

MaxQBiQ9C0K3
PaxDbiQ9C0K3
PeptideAtlasiQ9C0K3
PRIDEiQ9C0K3
ProteomicsDBi80071
80072 [Q9C0K3-2]

PTM databases

iPTMnetiQ9C0K3
PhosphoSitePlusiQ9C0K3

Expressioni

Tissue specificityi

Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus. Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones.1 Publication

Gene expression databases

BgeeiENSG00000106526
ExpressionAtlasiQ9C0K3 baseline and differential
GenevisibleiQ9C0K3 HS

Organism-specific databases

HPAiHPA055957

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi576126, 5 interactors
STRINGi9606.ENSP00000252071

Structurei

3D structure databases

ProteinModelPortaliQ9C0K3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0678 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00550000074695
HOGENOMiHOG000034070
HOVERGENiHBG075770
InParanoidiQ9C0K3
KOiK18584
OMAiIMERFME
PhylomeDBiQ9C0K3
TreeFamiTF300644

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR015623 Arp3
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF170 PTHR11937:SF170, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C0K3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP
60 70 80 90 100
VAEGYVIGSC IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE
110 120 130 140 150
KYCYICPDIV KEFAKYDVDP QKWIKQYTGI NAINQKKFVI DVGYERFLGP
160 170 180 190 200
EIFFHPEFAN PDSMESISDV VDEVIQNCPI DVRRPLYKME QIPLSYPQGH
210
GFHPLSPPFH
Length:210
Mass (Da):23,712
Last modified:June 1, 2001 - v1
Checksum:iAB94A33B440CD35B
GO
Isoform 2 (identifier: Q9C0K3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.

Note: No experimental confirmation available.
Show »
Length:47
Mass (Da):5,418
Checksum:iBFB88F46E446D136
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189M → V in CAI56711 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0322181 – 163Missing in isoform 2. 1 PublicationAdd BLAST163

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039791 mRNA Translation: BAB21501.1
BX640643 mRNA Translation: CAI56711.1
CCDSiCCDS47744.1 [Q9C0K3-1]
PIRiJC7580
RefSeqiNP_001157930.1, NM_001164458.1 [Q9C0K3-1]
NP_001157931.1, NM_001164459.1 [Q9C0K3-1]
XP_011514808.1, XM_011516506.2 [Q9C0K3-1]
XP_011514809.1, XM_011516507.2 [Q9C0K3-1]
XP_011514810.1, XM_011516508.2 [Q9C0K3-1]
XP_016868038.1, XM_017012549.1 [Q9C0K3-1]
UniGeneiHs.664579

Genome annotation databases

EnsembliENST00000252071; ENSP00000252071; ENSG00000106526 [Q9C0K3-1]
GeneIDi653857
KEGGihsa:653857
UCSCiuc003wgu.3 human [Q9C0K3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARP3C_HUMAN
AccessioniPrimary (citable) accession number: Q9C0K3
Secondary accession number(s): Q5CZI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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