UniProtKB - Q9C0K1 (S39A8_HUMAN)
Metal cation symporter ZIP8
SLC39A8
Functioni
Electroneutral transporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis or immunity (PubMed:12504855, PubMed:22898811, PubMed:23403290, PubMed:29337306, PubMed:26637978, PubMed:29453449).
Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation, a bicarbonate and a selenite anion or yet a metal cation and two bicarbonate anions (PubMed:27166256, PubMed:31699897).
May also transport iron, mercury and cobalt through membranes (PubMed:22898811).
Beside these endogenous cellular substrates, also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:27466201).
Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:29337306).
Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450).
Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290, PubMed:28056086).
Protects, for instance, cells from injury and death at the onset of inflammation (PubMed:18390834).
By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity).
At the apical membrane of hepatocytes, reclaims manganese from the bile and regulates, through the systemic levels of the nutrient, the activity of manganese-dependent enzymes (PubMed:28481222).
Also participates in manganese reabsorption in the proximal tubule of the kidney (PubMed:26637978).
By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain (PubMed:26637978, PubMed:31699897).
Through manganese cellular uptake also participates in mitochondrial proper function (PubMed:29453449).
Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (PubMed:19401385).
By similarity14 PublicationsCatalytic activityi
- hydrogencarbonate(out) + selenite(out) + Zn2+(out) = hydrogencarbonate(in) + selenite(in) + Zn2+(in)1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward3 Publications direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the backward1 Publication direction.
- This reaction proceeds in the backwardBy similarity direction.
- This reaction proceeds in the backwardBy similarity direction.
Kineticsi
- KM=1.44 µM for Mn2+1 Publication
GO - Molecular functioni
- anion:cation symporter activity Source: UniProtKB
- bicarbonate transmembrane transporter activity Source: UniProtKB
- cadmium ion transmembrane transporter activity Source: UniProtKB
- cobalt ion transmembrane transporter activity Source: UniProtKB
- iron ion transmembrane transporter activity Source: UniProtKB
- manganese ion transmembrane transporter activity Source: UniProtKB
- selenite:proton symporter activity Source: UniProtKB
- zinc:bicarbonate symporter activity Source: Ensembl
- zinc ion transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- arginine metabolic process Source: UniProtKB
- bicarbonate transport Source: UniProtKB
- cadmium ion transmembrane transport Source: UniProtKB
- cartilage homeostasis Source: UniProtKB
- cellular cadmium ion homeostasis Source: UniProtKB
- cellular manganese ion homeostasis Source: UniProtKB
- cellular zinc ion homeostasis Source: UniProtKB
- cobalt ion transport Source: UniProtKB
- extracellular matrix organization Source: UniProtKB
- iron ion import across plasma membrane Source: UniProtKB
- leukocyte adhesion to arterial endothelial cell Source: UniProtKB
- manganese ion transmembrane transport Source: UniProtKB
- mitochondrial manganese ion transmembrane transport Source: UniProtKB
- plasma membrane selenite transport Source: UniProtKB
- protein N-linked glycosylation Source: UniProtKB
- regulation of membrane potential Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- transcription, DNA-templated Source: Ensembl
- zinc ion import across plasma membrane Source: UniProtKB
- zinc ion transmembrane transport Source: UniProtKB
- zinc ion transport Source: UniProtKB
Keywordsi
Biological process | Ion transport, Transport, Zinc transport |
Ligand | Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9C0K1 |
Reactomei | R-HSA-442380, Zinc influx into cells by the SLC39 gene family |
SignaLinki | Q9C0K1 |
Protein family/group databases
TCDBi | 2.A.5.4.15, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family |
Names & Taxonomyi
Protein namesi | Recommended name: Metal cation symporter ZIP81 PublicationAlternative name(s): BCG-induced integral membrane protein in monocyte clone 103 protein1 Publication LIV-1 subfamily of ZIP zinc transporter 6 Short name: LZT-Hs6 Solute carrier family 39 member 8Imported Zrt- and Irt-like protein 8By similarity Short name: ZIP-8By similarity |
Gene namesi | ORF Names:PP3105 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20862, SLC39A8 |
MIMi | 608732, gene |
neXtProti | NX_Q9C0K1 |
VEuPathDBi | HostDB:ENSG00000138821 |
Subcellular locationi
Plasma membrane
- Cell membrane 4 Publications; Multi-pass membrane protein Sequence analysis
- Apical cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
- Basolateral cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Lysosome
- Lysosome membrane 3 Publications; Multi-pass membrane protein Sequence analysis
Note: Localizes to the lysosome of activated T-cells (PubMed:19401385). A large fraction of the protein is found intracellularly in microvascular capillary endothelial cells that constitute the blood-brain barrier (PubMed:31699897). Localized and functional at both apical and basolateral membranes of microvascular capillary endothelial cells that constitute the blood-brain barrier (PubMed:31699897).2 Publications
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- organelle membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 132 | ExtracellularBy similarityAdd BLAST | 110 | |
Transmembranei | 133 – 153 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 154 – 160 | CytoplasmicBy similarity | 7 | |
Transmembranei | 161 – 181 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 182 – 191 | ExtracellularBy similarity | 10 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 365 | CytoplasmicBy similarityAdd BLAST | 153 | |
Transmembranei | 366 – 386 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 387 – 388 | ExtracellularBy similarity | 2 | |
Transmembranei | 389 – 409 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 410 – 429 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 430 – 450 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 451 – 460 | ExtracellularBy similarity | 10 |
Keywords - Cellular componenti
Cell membrane, Lysosome, MembranePathology & Biotechi
Involvement in diseasei
Congenital disorder of glycosylation 2N (CDG2N)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076241 | 33 | V → M in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs373562040EnsemblClinVar. | 1 | |
Natural variantiVAR_076242 | 38 | G → R in CDG2N; loss of manganese ion transmembrane transport; loss of localization to the plasma membrane; retained in the endoplasmic reticulum; no effect on protein abundance. 3 PublicationsCorresponds to variant dbSNP:rs778210210EnsemblClinVar. | 1 | |
Natural variantiVAR_076243 | 204 | G → C in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs779241085EnsemblClinVar. | 1 | |
Natural variantiVAR_076244 | 335 | S → T in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs864309660EnsemblClinVar. | 1 | |
Natural variantiVAR_076245 | 340 | I → N in CDG2N; no detectable serum or urinary manganese levels in an affected individual who also carries R-38 mutation. 1 PublicationCorresponds to variant dbSNP:rs864309659EnsemblClinVar. | 1 |
Keywords - Diseasei
Congenital disorder of glycosylationOrganism-specific databases
DisGeNETi | 64116 |
MalaCardsi | SLC39A8 |
MIMi | 616721, phenotype |
OpenTargetsi | ENSG00000138821 |
Orphaneti | 468699, SLC39A8-CDG |
PharmGKBi | PA134931507 |
Miscellaneous databases
Pharosi | Q9C0K1, Tbio |
Chemistry databases
DrugBanki | DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | SLC39A8 |
DMDMi | 74733496 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000312707 | 23 – 460 | Metal cation symporter ZIP8Sequence analysisAdd BLAST | 438 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 40 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 88 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9C0K1 |
jPOSTi | Q9C0K1 |
MassIVEi | Q9C0K1 |
MaxQBi | Q9C0K1 |
PaxDbi | Q9C0K1 |
PeptideAtlasi | Q9C0K1 |
PRIDEi | Q9C0K1 |
ProteomicsDBi | 80068 [Q9C0K1-1] 80069 [Q9C0K1-2] 80070 [Q9C0K1-3] |
PTM databases
GlyGeni | Q9C0K1, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9C0K1 |
PhosphoSitePlusi | Q9C0K1 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000138821, Expressed in upper lobe of lung and 223 other tissues |
ExpressionAtlasi | Q9C0K1, baseline and differential |
Genevisiblei | Q9C0K1, HS |
Organism-specific databases
HPAi | ENSG00000138821, Tissue enhanced (lung) |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 122072, 35 interactors |
IntActi | Q9C0K1, 27 interactors |
MINTi | Q9C0K1 |
STRINGi | 9606.ENSP00000378310 |
Miscellaneous databases
RNActi | Q9C0K1, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 343 – 348 | XEXPHE-motif1 Publication | 6 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2693, Eukaryota |
GeneTreei | ENSGT00940000158926 |
HOGENOMi | CLU_015114_13_0_1 |
InParanoidi | Q9C0K1 |
OMAi | WLRGQRI |
OrthoDBi | 657777at2759 |
PhylomeDBi | Q9C0K1 |
TreeFami | TF318470 |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPGRAVAGL LLLAAAGLGG VAEGPGLAFS EDVLSVFGAN LSLSAAQLQH
60 70 80 90 100
LLEQMGAASR VGVPEPGQLH FNQCLTAEEI FSLHGFSNAT QITSSKFSVI
110 120 130 140 150
CPAVLQQLNF HPCEDRPKHK TRPSHSEVWG YGFLSVTIIN LASLLGLILT
160 170 180 190 200
PLIKKSYFPK ILTFFVGLAI GTLFSNAIFQ LIPEAFGFDP KVDSYVEKAV
210 220 230 240 250
AVFGGFYLLF FFERMLKMLL KTYGQNGHTH FGNDNFGPQE KTHQPKALPA
260 270 280 290 300
INGVTCYANP AVTEANGHIH FDNVSVVSLQ DGKKEPSSCT CLKGPKLSEI
310 320 330 340 350
GTIAWMITLC DALHNFIDGL AIGASCTLSL LQGLSTSIAI LCEEFPHELG
360 370 380 390 400
DFVILLNAGM STRQALLFNF LSACSCYVGL AFGILVGNNF APNIIFALAG
410 420 430 440 450
GMFLYISLAD MFPEMNDMLR EKVTGRKTDF TFFMIQNAGM LTGFTAILLI
460
TLYAGEIELE
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A804HJR0 | A0A804HJR0_HUMAN | Metal cation symporter ZIP8 | SLC39A8 | 290 | Annotation score: | ||
A0A804HKW0 | A0A804HKW0_HUMAN | Metal cation symporter ZIP8 | SLC39A8 | 450 | Annotation score: | ||
A0A804HKX2 | A0A804HKX2_HUMAN | Metal cation symporter ZIP8 | SLC39A8 | 350 | Annotation score: | ||
A0A804HHS9 | A0A804HHS9_HUMAN | Metal cation symporter ZIP8 | SLC39A8 | 143 | Annotation score: | ||
A0A804HHT0 | A0A804HHT0_HUMAN | Metal cation symporter ZIP8 | SLC39A8 | 78 | Annotation score: | ||
A0A804HKQ9 | A0A804HKQ9_HUMAN | Metal cation symporter ZIP8 | SLC39A8 | 87 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 241 | K → E in BAB55268 (PubMed:15498874).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076241 | 33 | V → M in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs373562040EnsemblClinVar. | 1 | |
Natural variantiVAR_076242 | 38 | G → R in CDG2N; loss of manganese ion transmembrane transport; loss of localization to the plasma membrane; retained in the endoplasmic reticulum; no effect on protein abundance. 3 PublicationsCorresponds to variant dbSNP:rs778210210EnsemblClinVar. | 1 | |
Natural variantiVAR_083148 | 113 | C → S Probable disease-associated variant found in patients with Leigh-like syndrome; no effect on protein abundance; loss of localization to the plasma membrane; retained in the endoplasmic reticulum; loss of manganese ion transmembrane transport. 1 PublicationCorresponds to variant dbSNP:rs1444255127EnsemblClinVar. | 1 | |
Natural variantiVAR_076243 | 204 | G → C in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs779241085EnsemblClinVar. | 1 | |
Natural variantiVAR_076244 | 335 | S → T in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs864309660EnsemblClinVar. | 1 | |
Natural variantiVAR_076245 | 340 | I → N in CDG2N; no detectable serum or urinary manganese levels in an affected individual who also carries R-38 mutation. 1 PublicationCorresponds to variant dbSNP:rs864309659EnsemblClinVar. | 1 | |
Natural variantiVAR_037551 | 391 | A → T No effect on protein abundance; decreased cadmium ion transmembrane transport; increased resistance to cadmium cytotoxicity; associated with decreased activity of manganese-dependent enzymes. 2 PublicationsCorresponds to variant dbSNP:rs13107325Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029884 | 1 – 67 | Missing in isoform 2. 1 PublicationAdd BLAST | 67 | |
Alternative sequenceiVSP_029885 | 68 – 72 | QLHFN → MHQHA in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_043675 | 423 – 460 | VTGRK…EIELE → IIKWATDDIKSQLHLLWIYT AR in isoform 3. 1 PublicationAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020970 mRNA Translation: BAA96442.1 AB040120 mRNA Translation: BAB21559.1 AK027652 mRNA Translation: BAB55268.1 AK304274 mRNA Translation: BAG65135.1 AF193052 mRNA Translation: AAG22480.1 AC098487 Genomic DNA No translation available. AP002023 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06130.1 BC001320 mRNA Translation: AAH01320.1 BC012125 mRNA Translation: AAH12125.1 |
CCDSi | CCDS3656.1 [Q9C0K1-1] CCDS47117.1 [Q9C0K1-3] |
RefSeqi | NP_001128618.1, NM_001135146.1 [Q9C0K1-1] NP_001128619.1, NM_001135147.1 [Q9C0K1-3] NP_001128620.1, NM_001135148.1 [Q9C0K1-2] NP_071437.3, NM_022154.5 [Q9C0K1-1] XP_005263234.1, XM_005263177.1 [Q9C0K1-1] XP_016864029.1, XM_017008540.1 XP_016864030.1, XM_017008541.1 [Q9C0K1-2] |
Genome annotation databases
Ensembli | ENST00000356736.5; ENSP00000349174.4; ENSG00000138821.14 ENST00000394833.6; ENSP00000378310.2; ENSG00000138821.14 ENST00000682227.1; ENSP00000508363.1; ENSG00000138821.14 ENST00000682932.1; ENSP00000507414.1; ENSG00000138821.14 ENST00000683412.1; ENSP00000507538.1; ENSG00000138821.14 |
GeneIDi | 64116 |
KEGGi | hsa:64116 |
MANE-Selecti | ENST00000356736.5; ENSP00000349174.4; NM_001135146.2; NP_001128618.1 |
UCSCi | uc003hwb.2, human [Q9C0K1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020970 mRNA Translation: BAA96442.1 AB040120 mRNA Translation: BAB21559.1 AK027652 mRNA Translation: BAB55268.1 AK304274 mRNA Translation: BAG65135.1 AF193052 mRNA Translation: AAG22480.1 AC098487 Genomic DNA No translation available. AP002023 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06130.1 BC001320 mRNA Translation: AAH01320.1 BC012125 mRNA Translation: AAH12125.1 |
CCDSi | CCDS3656.1 [Q9C0K1-1] CCDS47117.1 [Q9C0K1-3] |
RefSeqi | NP_001128618.1, NM_001135146.1 [Q9C0K1-1] NP_001128619.1, NM_001135147.1 [Q9C0K1-3] NP_001128620.1, NM_001135148.1 [Q9C0K1-2] NP_071437.3, NM_022154.5 [Q9C0K1-1] XP_005263234.1, XM_005263177.1 [Q9C0K1-1] XP_016864029.1, XM_017008540.1 XP_016864030.1, XM_017008541.1 [Q9C0K1-2] |
3D structure databases
AlphaFoldDBi | Q9C0K1 |
SMRi | Q9C0K1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122072, 35 interactors |
IntActi | Q9C0K1, 27 interactors |
MINTi | Q9C0K1 |
STRINGi | 9606.ENSP00000378310 |
Chemistry databases
DrugBanki | DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Protein family/group databases
TCDBi | 2.A.5.4.15, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family |
PTM databases
GlyGeni | Q9C0K1, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9C0K1 |
PhosphoSitePlusi | Q9C0K1 |
Genetic variation databases
BioMutai | SLC39A8 |
DMDMi | 74733496 |
Proteomic databases
EPDi | Q9C0K1 |
jPOSTi | Q9C0K1 |
MassIVEi | Q9C0K1 |
MaxQBi | Q9C0K1 |
PaxDbi | Q9C0K1 |
PeptideAtlasi | Q9C0K1 |
PRIDEi | Q9C0K1 |
ProteomicsDBi | 80068 [Q9C0K1-1] 80069 [Q9C0K1-2] 80070 [Q9C0K1-3] |
Protocols and materials databases
Antibodypediai | 45037, 176 antibodies from 29 providers |
DNASUi | 64116 |
Genome annotation databases
Organism-specific databases
CTDi | 64116 |
DisGeNETi | 64116 |
GeneCardsi | SLC39A8 |
HGNCi | HGNC:20862, SLC39A8 |
HPAi | ENSG00000138821, Tissue enhanced (lung) |
MalaCardsi | SLC39A8 |
MIMi | 608732, gene 616721, phenotype |
neXtProti | NX_Q9C0K1 |
OpenTargetsi | ENSG00000138821 |
Orphaneti | 468699, SLC39A8-CDG |
PharmGKBi | PA134931507 |
VEuPathDBi | HostDB:ENSG00000138821 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2693, Eukaryota |
GeneTreei | ENSGT00940000158926 |
HOGENOMi | CLU_015114_13_0_1 |
InParanoidi | Q9C0K1 |
OMAi | WLRGQRI |
OrthoDBi | 657777at2759 |
PhylomeDBi | Q9C0K1 |
TreeFami | TF318470 |
Enzyme and pathway databases
PathwayCommonsi | Q9C0K1 |
Reactomei | R-HSA-442380, Zinc influx into cells by the SLC39 gene family |
SignaLinki | Q9C0K1 |
Miscellaneous databases
BioGRID-ORCSi | 64116, 13 hits in 1079 CRISPR screens |
ChiTaRSi | SLC39A8, human |
GenomeRNAii | 64116 |
Pharosi | Q9C0K1, Tbio |
PROi | PR:Q9C0K1 |
RNActi | Q9C0K1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138821, Expressed in upper lobe of lung and 223 other tissues |
ExpressionAtlasi | Q9C0K1, baseline and differential |
Genevisiblei | Q9C0K1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S39A8_HUMAN | |
Accessioni | Q9C0K1Primary (citable) accession number: Q9C0K1 Secondary accession number(s): B4E2H3 Q9NSA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families