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Entry version 137 (18 Sep 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Zinc transporter ZIP8

Gene

SLC39A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a manganese and zinc influx transporter (PubMed:12504855, PubMed:26637978). Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain (PubMed:26637978).1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-442380 Zinc influx into cells by the SLC39 gene family

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.5.4.15 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc transporter ZIP8
Alternative name(s):
BCG-induced integral membrane protein in monocyte clone 103 protein
LIV-1 subfamily of ZIP zinc transporter 6
Short name:
LZT-Hs6
Solute carrier family 39 member 8
Zrt- and Irt-like protein 8
Short name:
ZIP-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC39A8
Synonyms:BIGM103, ZIP8
ORF Names:PP3105
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20862 SLC39A8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608732 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0K1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8ExtracellularSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 132CytoplasmicSequence analysisAdd BLAST103
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 160ExtracellularSequence analysis7
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 191CytoplasmicSequence analysis10
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 302ExtracellularSequence analysisAdd BLAST90
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 365CytoplasmicSequence analysisAdd BLAST42
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387 – 388ExtracellularSequence analysis2
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 429CytoplasmicSequence analysisAdd BLAST20
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 460ExtracellularSequence analysis10

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation 2N (CDG2N)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital disorder of glycosylation, a genetically heterogeneous group of autosomal recessive, multisystem disorders caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07624133V → M in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs373562040EnsemblClinVar.1
Natural variantiVAR_07624238G → R in CDG2N; lowered Mn and Zn blood levels and increased Mn and Zn urine levels in affected individuals. 2 PublicationsCorresponds to variant dbSNP:rs778210210EnsemblClinVar.1
Natural variantiVAR_076243204G → C in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs779241085EnsemblClinVar.1
Natural variantiVAR_076244335S → T in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs864309660EnsemblClinVar.1
Natural variantiVAR_076245340I → N in CDG2N; no detectable serum or urinary manganese levels in an affected individual who also carries R-38 mutation. 1 PublicationCorresponds to variant dbSNP:rs864309659EnsemblClinVar.1

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

DisGeNET

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DisGeNETi
64116

MalaCards human disease database

More...
MalaCardsi
SLC39A8
MIMi616721 phenotype

Open Targets

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OpenTargetsi
ENSG00000138821

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
468699 SLC39A8-CDG

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134931507

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC39A8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003127071 – 460Zinc transporter ZIP8Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9C0K1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9C0K1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9C0K1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9C0K1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9C0K1

PeptideAtlas

More...
PeptideAtlasi
Q9C0K1

PRoteomics IDEntifications database

More...
PRIDEi
Q9C0K1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80068 [Q9C0K1-1]
80069 [Q9C0K1-2]
80070 [Q9C0K1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0K1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0K1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By live and heat-killed Mycobacterium bovis bacterial cell wall and inflammatory cytokines like TNF. Down-regulated following phorbol ester treatment.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000138821 Expressed in 209 organ(s), highest expression level in upper lobe of lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9C0K1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9C0K1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038832
HPA038833

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122072, 32 interactors

Protein interaction database and analysis system

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IntActi
Q9C0K1, 27 interactors

Molecular INTeraction database

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MINTi
Q9C0K1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378310

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9C0K1

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi343 – 348XEXPHE-motif6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2693 Eukaryota
COG0428 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158926

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000070225

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9C0K1

KEGG Orthology (KO)

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KOi
K14714

Identification of Orthologs from Complete Genome Data

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OMAi
TAIVCEE

Database of Orthologous Groups

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OrthoDBi
657777at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9C0K1

TreeFam database of animal gene trees

More...
TreeFami
TF318470

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003689 ZIP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02535 Zip, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9C0K1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPGRAVAGL LLLAAAGLGG VAEGPGLAFS EDVLSVFGAN LSLSAAQLQH
60 70 80 90 100
LLEQMGAASR VGVPEPGQLH FNQCLTAEEI FSLHGFSNAT QITSSKFSVI
110 120 130 140 150
CPAVLQQLNF HPCEDRPKHK TRPSHSEVWG YGFLSVTIIN LASLLGLILT
160 170 180 190 200
PLIKKSYFPK ILTFFVGLAI GTLFSNAIFQ LIPEAFGFDP KVDSYVEKAV
210 220 230 240 250
AVFGGFYLLF FFERMLKMLL KTYGQNGHTH FGNDNFGPQE KTHQPKALPA
260 270 280 290 300
INGVTCYANP AVTEANGHIH FDNVSVVSLQ DGKKEPSSCT CLKGPKLSEI
310 320 330 340 350
GTIAWMITLC DALHNFIDGL AIGASCTLSL LQGLSTSIAI LCEEFPHELG
360 370 380 390 400
DFVILLNAGM STRQALLFNF LSACSCYVGL AFGILVGNNF APNIIFALAG
410 420 430 440 450
GMFLYISLAD MFPEMNDMLR EKVTGRKTDF TFFMIQNAGM LTGFTAILLI
460
TLYAGEIELE
Length:460
Mass (Da):49,631
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5C03F4576E11E2F
GO
Isoform 2 (identifier: Q9C0K1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     68-72: QLHFN → MHQHA

Note: No experimental confirmation available.
Show »
Length:393
Mass (Da):43,131
Checksum:i9ECB2D6D1FE89035
GO
Isoform 3 (identifier: Q9C0K1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-460: VTGRKTDFTFFMIQNAGMLTGFTAILLITLYAGEIELE → IIKWATDDIKSQLHLLWIYTAR

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):48,089
Checksum:i5EDFCF566871711A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti241K → E in BAB55268 (PubMed:15498874).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07624133V → M in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs373562040EnsemblClinVar.1
Natural variantiVAR_07624238G → R in CDG2N; lowered Mn and Zn blood levels and increased Mn and Zn urine levels in affected individuals. 2 PublicationsCorresponds to variant dbSNP:rs778210210EnsemblClinVar.1
Natural variantiVAR_076243204G → C in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs779241085EnsemblClinVar.1
Natural variantiVAR_076244335S → T in CDG2N. 1 PublicationCorresponds to variant dbSNP:rs864309660EnsemblClinVar.1
Natural variantiVAR_076245340I → N in CDG2N; no detectable serum or urinary manganese levels in an affected individual who also carries R-38 mutation. 1 PublicationCorresponds to variant dbSNP:rs864309659EnsemblClinVar.1
Natural variantiVAR_037551391A → T. Corresponds to variant dbSNP:rs13107325Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0298841 – 67Missing in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_02988568 – 72QLHFN → MHQHA in isoform 2. 1 Publication5
Alternative sequenceiVSP_043675423 – 460VTGRK…EIELE → IIKWATDDIKSQLHLLWIYT AR in isoform 3. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB020970 mRNA Translation: BAA96442.1
AB040120 mRNA Translation: BAB21559.1
AK027652 mRNA Translation: BAB55268.1
AK304274 mRNA Translation: BAG65135.1
AF193052 mRNA Translation: AAG22480.1
AC098487 Genomic DNA No translation available.
AP002023 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06130.1
BC001320 mRNA Translation: AAH01320.1
BC012125 mRNA Translation: AAH12125.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3656.1 [Q9C0K1-1]
CCDS47117.1 [Q9C0K1-3]

NCBI Reference Sequences

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RefSeqi
NP_001128618.1, NM_001135146.1 [Q9C0K1-1]
NP_001128619.1, NM_001135147.1 [Q9C0K1-3]
NP_001128620.1, NM_001135148.1 [Q9C0K1-2]
NP_071437.3, NM_022154.5 [Q9C0K1-1]
XP_005263234.1, XM_005263177.1 [Q9C0K1-1]
XP_016864029.1, XM_017008540.1
XP_016864030.1, XM_017008541.1 [Q9C0K1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000356736; ENSP00000349174; ENSG00000138821 [Q9C0K1-1]
ENST00000394833; ENSP00000378310; ENSG00000138821 [Q9C0K1-1]
ENST00000424970; ENSP00000394548; ENSG00000138821 [Q9C0K1-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64116

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64116

UCSC genome browser

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UCSCi
uc003hwb.2 human [Q9C0K1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020970 mRNA Translation: BAA96442.1
AB040120 mRNA Translation: BAB21559.1
AK027652 mRNA Translation: BAB55268.1
AK304274 mRNA Translation: BAG65135.1
AF193052 mRNA Translation: AAG22480.1
AC098487 Genomic DNA No translation available.
AP002023 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06130.1
BC001320 mRNA Translation: AAH01320.1
BC012125 mRNA Translation: AAH12125.1
CCDSiCCDS3656.1 [Q9C0K1-1]
CCDS47117.1 [Q9C0K1-3]
RefSeqiNP_001128618.1, NM_001135146.1 [Q9C0K1-1]
NP_001128619.1, NM_001135147.1 [Q9C0K1-3]
NP_001128620.1, NM_001135148.1 [Q9C0K1-2]
NP_071437.3, NM_022154.5 [Q9C0K1-1]
XP_005263234.1, XM_005263177.1 [Q9C0K1-1]
XP_016864029.1, XM_017008540.1
XP_016864030.1, XM_017008541.1 [Q9C0K1-2]

3D structure databases

SMRiQ9C0K1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122072, 32 interactors
IntActiQ9C0K1, 27 interactors
MINTiQ9C0K1
STRINGi9606.ENSP00000378310

Protein family/group databases

TCDBi2.A.5.4.15 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

PTM databases

iPTMnetiQ9C0K1
PhosphoSitePlusiQ9C0K1

Polymorphism and mutation databases

BioMutaiSLC39A8
DMDMi74733496

Proteomic databases

EPDiQ9C0K1
jPOSTiQ9C0K1
MassIVEiQ9C0K1
MaxQBiQ9C0K1
PaxDbiQ9C0K1
PeptideAtlasiQ9C0K1
PRIDEiQ9C0K1
ProteomicsDBi80068 [Q9C0K1-1]
80069 [Q9C0K1-2]
80070 [Q9C0K1-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64116
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356736; ENSP00000349174; ENSG00000138821 [Q9C0K1-1]
ENST00000394833; ENSP00000378310; ENSG00000138821 [Q9C0K1-1]
ENST00000424970; ENSP00000394548; ENSG00000138821 [Q9C0K1-3]
GeneIDi64116
KEGGihsa:64116
UCSCiuc003hwb.2 human [Q9C0K1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64116
DisGeNETi64116

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC39A8
HGNCiHGNC:20862 SLC39A8
HPAiHPA038832
HPA038833
MalaCardsiSLC39A8
MIMi608732 gene
616721 phenotype
neXtProtiNX_Q9C0K1
OpenTargetsiENSG00000138821
Orphaneti468699 SLC39A8-CDG
PharmGKBiPA134931507

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00940000158926
HOGENOMiHOG000070225
InParanoidiQ9C0K1
KOiK14714
OMAiTAIVCEE
OrthoDBi657777at2759
PhylomeDBiQ9C0K1
TreeFamiTF318470

Enzyme and pathway databases

ReactomeiR-HSA-442380 Zinc influx into cells by the SLC39 gene family

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC39A8 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64116

Pharos

More...
Pharosi
Q9C0K1

Protein Ontology

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PROi
PR:Q9C0K1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138821 Expressed in 209 organ(s), highest expression level in upper lobe of lung
ExpressionAtlasiQ9C0K1 baseline and differential
GenevisibleiQ9C0K1 HS

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS39A8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0K1
Secondary accession number(s): B4E2H3
, Q96SM9, Q9BVC0, Q9NSA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2001
Last modified: September 18, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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