BHLHE41

Functionⁱ

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.6 Publications

GO - Molecular functionⁱ

bHLH transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15193144
DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL
E-box binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 14672706
- 15193144
histone deacetylase binding Source: BHF-UCL
MRF binding Source: BHF-UCL
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15193144
protein homodimerization activity Source: BHF-UCL
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II activating transcription factor binding Source: BHF-UCL
RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: BHF-UCL
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific double-stranded DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19786558
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ morphogenesis
Source: UniProtKB
Non-traceable author statementⁱ
- 11162494
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell proliferation
Source: UniProtKB
Non-traceable author statementⁱ
- 11162494
circadian regulation of gene expression Source: Ensembl
negative regulation of myotube differentiation Source: BHF-UCL
negative regulation of transcription, DNA-templated Source: UniProtKB
negative regulation of transcription by competitive promoter binding Source: BHF-UCL
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 14672706
- 15193144
Notch signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of neurogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
somitogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-400253 Circadian Clock
SignaLinkⁱ	Q9C0J9
SIGNORⁱ	Q9C0J9

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Class E basic helix-loop-helix protein 41 Short name: bHLHe41 Alternative name(s): Class B basic helix-loop-helix protein 3 Short name: bHLHb3 Differentially expressed in chondrocytes protein 2 Short name: hDEC2 Enhancer-of-split and hairy-related protein 1 Short name: SHARP-1
Gene namesⁱ	Name:BHLHE41 Synonyms:BHLHB3, DEC2, SHARP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123095.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16617 BHLHE41
MIMⁱ	606200 gene
neXtProtⁱ	NX_Q9C0J9

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	70 – 71	LL → AA: Abolishes RXRA repression. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79365
MalaCards human disease database More...MalaCardsⁱ	BHLHE41
MIMⁱ	612975 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000123095
PharmGKBⁱ	PA164716636

Polymorphism and mutation databases

BioMutaⁱ	BHLHE41
DMDMⁱ	20137459

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127147	1 – 482	Class E basic helix-loop-helix protein 41Add BLAST		482

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Cross-linkⁱ	31	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	121	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	210	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	266	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q9C0J9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9C0J9
PaxDbⁱ	Q9C0J9
PeptideAtlas More...PeptideAtlasⁱ	Q9C0J9
PRIDEⁱ	Q9C0J9
ProteomicsDBⁱ	80065
TopDownProteomicsⁱ	Q9C0J9

PTM databases

iPTMnetⁱ	Q9C0J9
PhosphoSitePlusⁱ	Q9C0J9

Expressionⁱ

Tissue specificityⁱ

Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.

Gene expression databases

Bgeeⁱ	ENSG00000123095 Expressed in 221 organ(s), highest expression level in spinal cord
ExpressionAtlasⁱ	Q9C0J9 baseline and differential
Genevisibleⁱ	Q9C0J9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA056035

HPAⁱ

HPA056035

Interactionⁱ

Subunit structureⁱ

Homodimer. Heterodimer with BHLHE40/DEC1. Interacts with CIART and ARNTL/BMAL1 (By similarity). Interacts with RXRA.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
HIF1A	Q16665	2	EBI-10988877,EBI-447269

With

Entry

#Exp.

IntAct

Notes

HIF1A

Q16665

2

EBI-10988877,EBI-447269

GO - Molecular functionⁱ

bHLH transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15193144
histone deacetylase binding Source: BHF-UCL
MRF binding Source: BHF-UCL
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15193144
protein homodimerization activity Source: BHF-UCL
RNA polymerase II activating transcription factor binding Source: BHF-UCL
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	122654, 38 interactors
Database of interacting proteins More...DIPⁱ	DIP-59904N
IntActⁱ	Q9C0J9, 10 interactors
STRINGⁱ	9606.ENSP00000242728

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9C0J9
SMRⁱ	Q9C0J9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	44 – 99	bHLHPROSITE-ProRule annotationAdd BLAST		56
Domainⁱ	131 – 166	OrangePROSITE-ProRule annotationAdd BLAST		36

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	67 – 71	Necessary for interaction with RXRA and repressor activity towards RXRA1 Publication		5

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	297 – 431	Ala/Gly-richAdd BLAST		135

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046898
HOGENOMⁱ	HOG000234381
HOVERGENⁱ	HBG050685
InParanoidⁱ	Q9C0J9
KEGG Orthology (KO) More...KOⁱ	K03730
OMAⁱ	LYMCKSK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0D3I
PhylomeDBⁱ	Q9C0J9
TreeFamⁱ	TF330859

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00511 ORANGE, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9C0J9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDEGIPHLQE RQLLEHRDFI GLDYSSLYMC KPKRSMKRDD TKDTYKLPHR 
        60         70         80         90        100
LIEKKRRDRI NECIAQLKDL LPEHLKLTTL GHLEKAVVLE LTLKHLKALT 
       110        120        130        140        150
ALTEQQHQKI IALQNGERSL KSPIQSDLDA FHSGFQTCAK EVLQYLSRFE 
       160        170        180        190        200
SWTPREPRCV QLINHLHAVA TQFLPTPQLL TQQVPLSKGT GAPSAAGSAA 
       210        220        230        240        250
APCLERAGQK LEPLAYCVPV IQRTQPSAEL AAENDTDTDS GYGGEAEARP 
       260        270        280        290        300
DREKGKGAGA SRVTIKQEPP GEDSPAPKRM KLDSRGGGSG GGPGGGAAAA 
       310        320        330        340        350
AAALLGPDPA AAAALLRPDA ALLSSLVAFG GGGGAPFPQP AAAAAPFCLP 
       360        370        380        390        400
FCFLSPSAAA AYVQPFLDKS GLEKYLYPAA AAAPFPLLYP GIPAPAAAAA 
       410        420        430        440        450
AAAAAAAAAA AFPCLSSVLS PPPEKAGAAA ATLLPHEVAP LGAPHPQHPH 
       460        470        480 
GRTHLPFAGP REPGNPESSA QEDPSQPGKE AP

Length:482

Mass (Da):50,498

Last modified:June 1, 2001 - v1

Checksum:ⁱ2BECDC2FDEB7CE14

GO

Polymorphismⁱ

Genetic variations in BHLHE41 are associated with the short sleep phenotype [MIMⁱ:612975]. Individuals with this trait require less sleep in any 24-hour period than is typical for their age group.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063259	384	P → R Associated with short sleep phenotype. 1 PublicationCorresponds to variant dbSNP:rs121912617EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB044088 mRNA Translation: BAB21502.1 EF015896 Genomic DNA Translation: ABM64207.1 CH471094 Genomic DNA Translation: EAW96527.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8706.1
PIRⁱ	JC7583
NCBI Reference Sequences More...RefSeqⁱ	NP_110389.1, NM_030762.2
UniGeneⁱ	Hs.177841

Genome annotation databases

Ensemblⁱ	ENST00000242728; ENSP00000242728; ENSG00000123095
GeneIDⁱ	79365
KEGGⁱ	hsa:79365
UCSC genome browser More...UCSCⁱ	uc001rhb.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9C0J9	Basic helix-loop-helix domain containing, class B, 3, isoform CRA_a		HUMAN		482	UniRef100_Q9C0J9
BHLHE41 isoform 1		PANTR		482
Class E basic helix-loop-helix protein 41 (Fragment)		MACMU		90

Protein	Similar proteins		Species	Score	Length	Source
Q9C0J9	Basic helix-loop-helix domain containing, class B, 3, isoform CRA_a		HUMAN		482	UniRef90_Q9C0J9
BHLHE41 isoform 1		PANTR		482
Class E basic helix-loop-helix protein 41 (Fragment)		MACMU		90
Uncharacterized protein		FELCA		594
class E basic helix-loop-helix protein 41		ODORO		484
+40

Protein	Similar proteins		Species	Score	Length	Source
Q9C0J9	Basic helix-loop-helix domain containing, class B, 3, isoform CRA_a		HUMAN		482	UniRef50_Q9C0J9
BHLHE41 isoform 1		PANTR		482
Class E basic helix-loop-helix protein 41 (Fragment)		MACMU		90
Uncharacterized protein		FELCA		594
class E basic helix-loop-helix protein 41		ODORO		484
+41

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB044088 mRNA Translation: BAB21502.1 EF015896 Genomic DNA Translation: ABM64207.1 CH471094 Genomic DNA Translation: EAW96527.1
CCDSⁱ	CCDS8706.1
PIRⁱ	JC7583
RefSeqⁱ	NP_110389.1, NM_030762.2
UniGeneⁱ	Hs.177841

3D structure databases

ProteinModelPortalⁱ	Q9C0J9
SMRⁱ	Q9C0J9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122654, 38 interactors
DIPⁱ	DIP-59904N
IntActⁱ	Q9C0J9, 10 interactors
STRINGⁱ	9606.ENSP00000242728

PTM databases

iPTMnetⁱ	Q9C0J9
PhosphoSitePlusⁱ	Q9C0J9

Polymorphism and mutation databases

BioMutaⁱ	BHLHE41
DMDMⁱ	20137459

Proteomic databases

EPDⁱ	Q9C0J9
MaxQBⁱ	Q9C0J9
PaxDbⁱ	Q9C0J9
PeptideAtlasⁱ	Q9C0J9
PRIDEⁱ	Q9C0J9
ProteomicsDBⁱ	80065
TopDownProteomicsⁱ	Q9C0J9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000242728; ENSP00000242728; ENSG00000123095
GeneIDⁱ	79365
KEGGⁱ	hsa:79365
UCSCⁱ	uc001rhb.4 human

Organism-specific databases

CTDⁱ	79365
DisGeNETⁱ	79365
EuPathDBⁱ	HostDB:ENSG00000123095.5
GeneCardsⁱ	BHLHE41
HGNCⁱ	HGNC:16617 BHLHE41
HPAⁱ	HPA056035
MalaCardsⁱ	BHLHE41
MIMⁱ	606200 gene 612975 phenotype
neXtProtⁱ	NX_Q9C0J9
OpenTargetsⁱ	ENSG00000123095
PharmGKBⁱ	PA164716636
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
GeneTreeⁱ	ENSGT00510000046898
HOGENOMⁱ	HOG000234381
HOVERGENⁱ	HBG050685
InParanoidⁱ	Q9C0J9
KOⁱ	K03730
OMAⁱ	LYMCKSK
OrthoDBⁱ	EOG091G0D3I
PhylomeDBⁱ	Q9C0J9
TreeFamⁱ	TF330859

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-400253 Circadian Clock
SignaLinkⁱ	Q9C0J9
SIGNORⁱ	Q9C0J9

Miscellaneous databases

ChiTaRSⁱ	BHLHE41 human
GeneWikiⁱ	BHLHB3
GenomeRNAiⁱ	79365
Protein Ontology More...PROⁱ	PR:Q9C0J9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123095 Expressed in 221 organ(s), highest expression level in spinal cord
ExpressionAtlasⁱ	Q9C0J9 baseline and differential
Genevisibleⁱ	Q9C0J9 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00511 ORANGE, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BHE41_HUMAN
Accessionⁱ	Q9C0J9Primary (citable) accession number: Q9C0J9 Secondary accession number(s): A2I2N8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9C0J9 (BHE41_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Class E basic helix-loop-helix protein 41

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ