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Entry version 142 (11 Dec 2019)
Sequence version 2 (24 Jan 2006)
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Protein

Leucine-rich repeat-containing protein 27

Gene

LRRC27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC27
Synonyms:KIAA1674
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000148814.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29346 LRRC27

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0I9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000148814

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134904045

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9C0I9 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC27

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85701139

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762421 – 530Leucine-rich repeat-containing protein 27Add BLAST530

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9C0I9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C0I9

PeptideAtlas

More...
PeptideAtlasi
Q9C0I9

PRoteomics IDEntifications database

More...
PRIDEi
Q9C0I9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80056 [Q9C0I9-1]
80057 [Q9C0I9-2]
80058 [Q9C0I9-3]
80059 [Q9C0I9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0I9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0I9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148814 Expressed in 146 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C0I9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C0I9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037595
HPA067395

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123226, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q9C0I9, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357603

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9C0I9 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati46 – 67LRR 1Add BLAST22
Repeati68 – 89LRR 2Add BLAST22
Repeati92 – 113LRR 3Add BLAST22
Repeati115 – 136LRR 4Add BLAST22
Repeati138 – 159LRR 5Add BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili327 – 385Sequence analysisAdd BLAST59

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISCS Eukaryota
ENOG4112CNT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007203

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0I9

Identification of Orthologs from Complete Genome Data

More...
OMAi
KIPFATD

Database of Orthologous Groups

More...
OrthoDBi
1019074at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C0I9

TreeFam database of animal gene trees

More...
TreeFami
TF351877

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9C0I9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGSSSYEVP SVAAADLEEG AGQTRSLPAT PSKDVHKGVG GIIFSSSPIL
60 70 80 90 100
DLSESGLCRL EEVFRIPSLQ QLHLQRNALC VIPQDFFQLL PNLTWLDLRY
110 120 130 140 150
NRIKALPSGI GAHQHLKTLL LERNPIKMLP VELGSVTTLK ALNLRHCPLE
160 170 180 190 200
FPPQLVVQKG LVAIQRFLRM WAVEHSLPRN PTSQEAPPVR EMTLRDLPSP
210 220 230 240 250
GLELSGDHAS NQGAVNAQDP EGAVMKEKAS FLPPVEKPDL SELRKSADSS
260 270 280 290 300
ENWPSEEEIR RFWKLRQEIV EHVKADVLGD QLLTRELPPN LKAALNIEKE
310 320 330 340 350
LPKPRHVFRR KTASSRSILP DLLSPYQMAI RAKRLEESRA AALRELQEKQ
360 370 380 390 400
ALMEQQRREK RALQEWRERA QRMRKRKEEL SKLLPPRRSM VASKIPSATD
410 420 430 440 450
LIDNRKVPLN PPGKMKPSKE KSPQASKEMS ALQERNLEEK IKQHVLQMRE
460 470 480 490 500
QRRFHGQAPL EEMRKAAEDL EIATELQDEV LKLKLGLTLN KDRRRAALTG
510 520 530
NLSLGLPAAQ PQNTFFNTKY GESGNVRRYQ
Length:530
Mass (Da):60,089
Last modified:January 24, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EA76B0A0566DDAC
GO
Isoform 2 (identifier: Q9C0I9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: MEGSSSYEVP...EEVFRIPSLQ → MDINTYNN

Show »
Length:468
Mass (Da):53,768
Checksum:i5A27E117E7B2892B
GO
Isoform 3 (identifier: Q9C0I9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     310-383: RKTASSRSIL...RKRKEELSKL → TRVPRKQALQ...RSESSRRSRL
     384-530: Missing.

Show »
Length:383
Mass (Da):43,220
Checksum:iA787D219A5DEFE38
GO
Isoform 4 (identifier: Q9C0I9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-383: EKRALQEWRERAQRMRKRKEELSKL → PFLLIFPRVFQALTRSSGRFILVLL
     384-530: Missing.

Show »
Length:383
Mass (Da):43,071
Checksum:i1F18081B5C3394DE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB21765 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti221E → K in BAC04108 (PubMed:14702039).Curated1
Isoform 2 (identifier: Q9C0I9-2)
Sequence conflicti256I → V in BAC04108 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051110195R → C. Corresponds to variant dbSNP:rs2474329Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0170391 – 70MEGSS…IPSLQ → MDINTYNN in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_017040310 – 383RKTAS…ELSKL → TRVPRKQALQRLHERKTRIM GVVGRAPTHMGEGRQPPPGA SYPTSCHRTKWRSEQKDWKR AERRRSESSRRSRL in isoform 3. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_017042359 – 383EKRAL…ELSKL → PFLLIFPRVFQALTRSSGRF ILVLL in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_017041384 – 530Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST147

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB051461 mRNA Translation: BAB21765.1 Different initiation.
AK093250 mRNA Translation: BAC04108.1
AK098652 mRNA Translation: BAC05366.1
AL590105 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49121.1
CH471066 Genomic DNA Translation: EAW49122.1
CH471066 Genomic DNA Translation: EAW49123.1
BC050097 mRNA Translation: AAH50097.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31316.1 [Q9C0I9-1]
CCDS44495.1 [Q9C0I9-4]
CCDS44496.1 [Q9C0I9-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001137229.1, NM_001143757.1 [Q9C0I9-1]
NP_001137230.1, NM_001143758.1 [Q9C0I9-4]
NP_001137231.1, NM_001143759.1 [Q9C0I9-3]
NP_085129.1, NM_030626.2 [Q9C0I9-1]
XP_006718046.1, XM_006717983.2
XP_011538510.1, XM_011540208.1 [Q9C0I9-1]
XP_016872181.1, XM_017016692.1 [Q9C0I9-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344079; ENSP00000342641; ENSG00000148814 [Q9C0I9-3]
ENST00000368612; ENSP00000357601; ENSG00000148814 [Q9C0I9-2]
ENST00000368613; ENSP00000357602; ENSG00000148814 [Q9C0I9-1]
ENST00000368614; ENSP00000357603; ENSG00000148814 [Q9C0I9-1]
ENST00000625755; ENSP00000486582; ENSG00000148814 [Q9C0I9-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80313

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80313

UCSC genome browser

More...
UCSCi
uc001llf.3 human [Q9C0I9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051461 mRNA Translation: BAB21765.1 Different initiation.
AK093250 mRNA Translation: BAC04108.1
AK098652 mRNA Translation: BAC05366.1
AL590105 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49121.1
CH471066 Genomic DNA Translation: EAW49122.1
CH471066 Genomic DNA Translation: EAW49123.1
BC050097 mRNA Translation: AAH50097.1
CCDSiCCDS31316.1 [Q9C0I9-1]
CCDS44495.1 [Q9C0I9-4]
CCDS44496.1 [Q9C0I9-3]
RefSeqiNP_001137229.1, NM_001143757.1 [Q9C0I9-1]
NP_001137230.1, NM_001143758.1 [Q9C0I9-4]
NP_001137231.1, NM_001143759.1 [Q9C0I9-3]
NP_085129.1, NM_030626.2 [Q9C0I9-1]
XP_006718046.1, XM_006717983.2
XP_011538510.1, XM_011540208.1 [Q9C0I9-1]
XP_016872181.1, XM_017016692.1 [Q9C0I9-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123226, 11 interactors
IntActiQ9C0I9, 12 interactors
STRINGi9606.ENSP00000357603

PTM databases

iPTMnetiQ9C0I9
PhosphoSitePlusiQ9C0I9

Polymorphism and mutation databases

BioMutaiLRRC27
DMDMi85701139

Proteomic databases

jPOSTiQ9C0I9
PaxDbiQ9C0I9
PeptideAtlasiQ9C0I9
PRIDEiQ9C0I9
ProteomicsDBi80056 [Q9C0I9-1]
80057 [Q9C0I9-2]
80058 [Q9C0I9-3]
80059 [Q9C0I9-4]

Genome annotation databases

EnsembliENST00000344079; ENSP00000342641; ENSG00000148814 [Q9C0I9-3]
ENST00000368612; ENSP00000357601; ENSG00000148814 [Q9C0I9-2]
ENST00000368613; ENSP00000357602; ENSG00000148814 [Q9C0I9-1]
ENST00000368614; ENSP00000357603; ENSG00000148814 [Q9C0I9-1]
ENST00000625755; ENSP00000486582; ENSG00000148814 [Q9C0I9-4]
GeneIDi80313
KEGGihsa:80313
UCSCiuc001llf.3 human [Q9C0I9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80313
EuPathDBiHostDB:ENSG00000148814.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRC27
HGNCiHGNC:29346 LRRC27
HPAiHPA037595
HPA067395
neXtProtiNX_Q9C0I9
OpenTargetsiENSG00000148814
PharmGKBiPA134904045

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISCS Eukaryota
ENOG4112CNT LUCA
GeneTreeiENSGT00390000007203
InParanoidiQ9C0I9
OMAiKIPFATD
OrthoDBi1019074at2759
PhylomeDBiQ9C0I9
TreeFamiTF351877

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRRC27 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80313
PharosiQ9C0I9 Tdark

Protein Ontology

More...
PROi
PR:Q9C0I9
RNActiQ9C0I9 protein

Gene expression databases

BgeeiENSG00000148814 Expressed in 146 organ(s), highest expression level in testis
ExpressionAtlasiQ9C0I9 baseline and differential
GenevisibleiQ9C0I9 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC27_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0I9
Secondary accession number(s): A6NE72
, A6NJB4, A6NKD3, D3DRH0, Q5SZH6, Q5SZH8, Q5SZH9, Q86XT5, Q8N7C8, Q8NA21
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: December 11, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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