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Entry version 109 (12 Aug 2020)
Sequence version 3 (13 Nov 2019)
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Protein

Thrombospondin type-1 domain-containing protein 7B

Gene

THSD7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9C0I4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214, O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thrombospondin type-1 domain-containing protein 7BCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THSD7BImported
Synonyms:KIAA1679
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000144229.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29348, THSD7B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9C0I4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 1555ExtracellularSequence analysisAdd BLAST1524
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1556 – 1576HelicalSequence analysisAdd BLAST21
Topological domaini1577 – 1606CytoplasmicSequence analysisAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80731

Open Targets

More...
OpenTargetsi
ENSG00000144229

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9C0I4, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
THSD7B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118574152

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000026025132 – 1606Thrombospondin type-1 domain-containing protein 7BAdd BLAST1575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi411 ↔ 477PROSITE-ProRule annotation
Disulfide bondi431 ↔ 481PROSITE-ProRule annotation
Disulfide bondi442 ↔ 466PROSITE-ProRule annotation
Disulfide bondi602 ↔ 643PROSITE-ProRule annotation
Disulfide bondi613 ↔ 617PROSITE-ProRule annotation
Disulfide bondi655 ↔ 660PROSITE-ProRule annotation
Glycosylationi683N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi738 ↔ 779PROSITE-ProRule annotation
Disulfide bondi749 ↔ 753PROSITE-ProRule annotation
Glycosylationi757N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi789 ↔ 795PROSITE-ProRule annotation
Glycosylationi842N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi872 ↔ 907PROSITE-ProRule annotation
Disulfide bondi883 ↔ 887PROSITE-ProRule annotation
Disulfide bondi921 ↔ 923PROSITE-ProRule annotation
Glycosylationi933N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi937 ↔ 993PROSITE-ProRule annotation
Disulfide bondi959 ↔ 997PROSITE-ProRule annotation
Disulfide bondi970 ↔ 983PROSITE-ProRule annotation
Disulfide bondi1001 ↔ 1038PROSITE-ProRule annotation
Disulfide bondi1012 ↔ 1016PROSITE-ProRule annotation
Disulfide bondi1120 ↔ 1124PROSITE-ProRule annotation
Glycosylationi1186N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1248 ↔ 1286PROSITE-ProRule annotation
Disulfide bondi1259 ↔ 1263PROSITE-ProRule annotation
Disulfide bondi1296 ↔ 1301PROSITE-ProRule annotation
Glycosylationi1308N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1371 ↔ 1415PROSITE-ProRule annotation
Disulfide bondi1382 ↔ 1386PROSITE-ProRule annotation
Disulfide bondi1425 ↔ 1430PROSITE-ProRule annotation
Glycosylationi1456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1524N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9C0I4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9C0I4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9C0I4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9C0I4

PeptideAtlas

More...
PeptideAtlasi
Q9C0I4

PRoteomics IDEntifications database

More...
PRIDEi
Q9C0I4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
16878
80055

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9C0I4, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9C0I4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9C0I4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144229, Expressed in pigmented layer of retina and 129 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9C0I4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9C0I4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000144229, Tissue enhanced (brain, epididymis, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9C0I4, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000272643

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9C0I4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 98TSP type-1 1PROSITE-ProRule annotationAdd BLAST59
Domaini102 – 177TSP type-1 2PROSITE-ProRule annotationAdd BLAST76
Domaini179 – 233TSP type-1 3PROSITE-ProRule annotationAdd BLAST55
Domaini336 – 392TSP type-1 4PROSITE-ProRule annotationAdd BLAST57
Domaini399 – 482TSP type-1 5PROSITE-ProRule annotationAdd BLAST84
Domaini484 – 543TSP type-1 6PROSITE-ProRule annotationAdd BLAST60
Domaini601 – 661TSP type-1 7PROSITE-ProRule annotationAdd BLAST61
Domaini662 – 735TSP type-1 8PROSITE-ProRule annotationAdd BLAST74
Domaini737 – 796TSP type-1 9PROSITE-ProRule annotationAdd BLAST60
Domaini797 – 869TSP type-1 10PROSITE-ProRule annotationAdd BLAST73
Domaini871 – 924TSP type-1 11PROSITE-ProRule annotationAdd BLAST54
Domaini925 – 998TSP type-1 12PROSITE-ProRule annotationAdd BLAST74
Domaini1000 – 1125TSP type-1 13PROSITE-ProRule annotationAdd BLAST126
Domaini1127 – 1181TSP type-1 14PROSITE-ProRule annotationAdd BLAST55
Domaini1182 – 1245TSP type-1 15PROSITE-ProRule annotationAdd BLAST64
Domaini1247 – 1302TSP type-1 16PROSITE-ProRule annotationAdd BLAST56
Domaini1303 – 1368TSP type-1 17PROSITE-ProRule annotationAdd BLAST66
Domaini1370 – 1431TSP type-1 18PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi584 – 589Poly-Pro6

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159262

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004819_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9C0I4

Database of Orthologous Groups

More...
OrthoDBi
20284at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9C0I4

TreeFam database of animal gene trees

More...
TreeFami
TF329791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00090, TSP_1, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895, SSF82895, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50092, TSP1, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9C0I4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPKSNLTVT CWVWRSMRKL FLLLSLLLSH AAHLEGKKDN QFIWKPGPWG
60 70 80 90 100
RCTGDCGPGG VQSRAVWCFH VDGWTSHLSN CGESNRPPKE RSCFRVCDWH
110 120 130 140 150
SDLFQWEVSD WHHCVLVPYA RGEVKPRTAE CVTAQHGLQH RMVRCIQKLN
160 170 180 190 200
RTVVANEICE HFALQPPTEQ ACLIPCPRDC VVSEFLPWSN CSKGCGKKLQ
210 220 230 240 250
HRTRAVIAPP LFGGLQCPNL TESRACDAPI SCPLGEEEYT FSLKVGPWSK
260 270 280 290 300
CRLPHLKEIN PSGRTVLDFN SDSNERVTFK HQSYKAHHHS KSWAIEIGYQ
310 320 330 340 350
TRQVSCTRSD GQNAMLSLCL QDSFPLTVQS CIMPKDCETS QWSSWSPCSK
360 370 380 390 400
TCRSGSLLPG FRSRSRNVKH MAIGGGKECP ELLEKEACIV EGELLQQCPR
410 420 430 440 450
YSWRTSEWKE CQVSLLLEQQ DPHWHVTGPV CGGGIQTREV YCAQSVPAAA
460 470 480 490 500
ALRAKEVSRP VEKALCVGPA PLPSQLCNIP CSTDCIVSSW SAWGLCIHEN
510 520 530 540 550
CHDPQGKKGF RTRQRHVLME STGPAGHCPH LVESVPCEDP MCYRWLASEG
560 570 580 590 600
ICFPDHGKCG LGHRILKAVC QNDRGEDVSG SLCPVPPPPE RKSCEIPCRM
610 620 630 640 650
DCVLSEWTEW SSCSQSCSNK NSDGKQTRSR TILALAGEGG KPCPPSQALQ
660 670 680 690 700
EHRLCNDHSC MQLHWETSPW GPCSEDTLVT ALNATIGWNG EATCGVGIQT
710 720 730 740 750
RRVFCVKSHV GQVMTKRCPD STRPETVRPC FLPCKKDCIV TAFSEWTPCP
760 770 780 790 800
RMCQAGNATV KQSRYRIIIQ EAANGGQECP DTLYEERECE DVSLCPVYRW
810 820 830 840 850
KPQKWSPCIL VPESVWQGIT GSSEACGKGL QTRAVSCISD DNRSAEMMEC
860 870 880 890 900
LKQTNGMPLL VQECTVPCRE DCTFTAWSKF TPCSTNCEAT KSRRRQLTGK
910 920 930 940 950
SRKKEKCQDS DLYPLVETEL CPCDEFISQP YGNWSDCILP EGRREPHRGL
960 970 980 990 1000
RVQADSKECG EGLRFRAVAC SDKNGRPVDP SFCSSSGYIQ EKCVIPCPFD
1010 1020 1030 1040 1050
CKLSDWSSWG SCSSSCGIGV RIRSKWLKEK PYNGGRPCPK LDLKNQVHEA
1060 1070 1080 1090 1100
VPCYSECNQY SWVVEHWSSC KINNELRSLR CGGGTQSRKI RCVNTADGEG
1110 1120 1130 1140 1150
GAVDSNLCNQ DEIPPETQSC SLMCPNECVM SEWGLWSKCP QSCDPHTMQR
1160 1170 1180 1190 1200
RTRHLLRPSL NSRTCAEDSQ VQPCLLNENC FQFQYNLTEW STCQLSENAP
1210 1220 1230 1240 1250
CGQGVRTRLL SCVCSDGKPV SMDQCEQHNL EKPQRMSIPC LVECVVNCQL
1260 1270 1280 1290 1300
SGWTAWTECS QTCGHGGRMS RTRFIIMPTQ GEGRPCPTEL TQEKTCPVTP
1310 1320 1330 1340 1350
CYSWVLGNWS ACKLEGGDCG EGVQIRSLSC MVHSGSISHA AGRVEDALCG
1360 1370 1380 1390 1400
EMPFQDSILK QLCSVPCPGD CHLTEWSEWS TCELTCIDGR SFETVGRQSR
1410 1420 1430 1440 1450
SRTFIIQSFE NQDSCPQQVL ETRPCTGGKC YHYTWKASLW NNNERTVWCQ
1460 1470 1480 1490 1500
RSDGVNVTGG CSPQARPAAI RQCIPACRKP FSYCTQGGVC GCEKGYTEIM
1510 1520 1530 1540 1550
KSNGFLDYCM KVPGSEDKKA DVKNLSGKNR PVNSKIHDIF KGWSLQPLDP
1560 1570 1580 1590 1600
DGRVKIWVYG VSGGAFLIMI FLIFTSYLVC KKPKPHQSTP PQQKPLTLAY

DGDLDM
Length:1,606
Mass (Da):179,199
Last modified:November 13, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0947780C9CAD0B8C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JKN6C9JKN6_HUMAN
Thrombospondin type-1 domain-contai...
THSD7B
1,577Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5K1VW52A0A5K1VW52_HUMAN
Thrombospondin type-1 domain-contai...
THSD7B
1,608Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMU2R4GMU2_HUMAN
Thrombospondin type-1 domain-contai...
THSD7B
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti503D → E in BAB21770 (PubMed:11214970).Curated1
Sequence conflicti1046Q → QAQ in BAB21770 (PubMed:11214970).Curated1
Sequence conflicti1501K → R in BAB21770 (PubMed:11214970).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010100 Genomic DNA No translation available.
AC010873 Genomic DNA No translation available.
AC011231 Genomic DNA No translation available.
AC012000 Genomic DNA No translation available.
AC016679 Genomic DNA No translation available.
AC017082 Genomic DNA No translation available.
AC019067 Genomic DNA No translation available.
KF456714 Genomic DNA No translation available.
AB051466 mRNA Translation: BAB21770.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS82515.1

NCBI Reference Sequences

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RefSeqi
NP_001303278.1, NM_001316349.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000409968; ENSP00000387145; ENSG00000144229

Database of genes from NCBI RefSeq genomes

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GeneIDi
80731

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80731

UCSC genome browser

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UCSCi
uc061ocl.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010100 Genomic DNA No translation available.
AC010873 Genomic DNA No translation available.
AC011231 Genomic DNA No translation available.
AC012000 Genomic DNA No translation available.
AC016679 Genomic DNA No translation available.
AC017082 Genomic DNA No translation available.
AC019067 Genomic DNA No translation available.
KF456714 Genomic DNA No translation available.
AB051466 mRNA Translation: BAB21770.1
CCDSiCCDS82515.1
RefSeqiNP_001303278.1, NM_001316349.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9C0I4, 3 interactors
STRINGi9606.ENSP00000272643

PTM databases

GlyGeniQ9C0I4, 7 sites
iPTMnetiQ9C0I4
PhosphoSitePlusiQ9C0I4

Polymorphism and mutation databases

BioMutaiTHSD7B
DMDMi118574152

Proteomic databases

EPDiQ9C0I4
jPOSTiQ9C0I4
MassIVEiQ9C0I4
PaxDbiQ9C0I4
PeptideAtlasiQ9C0I4
PRIDEiQ9C0I4
ProteomicsDBi16878
80055

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
62318, 9 antibodies

Genome annotation databases

EnsembliENST00000409968; ENSP00000387145; ENSG00000144229
GeneIDi80731
KEGGihsa:80731
UCSCiuc061ocl.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80731
DisGeNETi80731
EuPathDBiHostDB:ENSG00000144229.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
THSD7B
HGNCiHGNC:29348, THSD7B
HPAiENSG00000144229, Tissue enhanced (brain, epididymis, retina)
neXtProtiNX_Q9C0I4
OpenTargetsiENSG00000144229

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
GeneTreeiENSGT00940000159262
HOGENOMiCLU_004819_0_0_1
InParanoidiQ9C0I4
OrthoDBi20284at2759
PhylomeDBiQ9C0I4
TreeFamiTF329791

Enzyme and pathway databases

PathwayCommonsiQ9C0I4
ReactomeiR-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
80731, 4 hits in 133 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
THSD7B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80731
PharosiQ9C0I4, Tdark

Protein Ontology

More...
PROi
PR:Q9C0I4
RNActiQ9C0I4, protein

Gene expression databases

BgeeiENSG00000144229, Expressed in pigmented layer of retina and 129 other tissues
ExpressionAtlasiQ9C0I4, baseline and differential
GenevisibleiQ9C0I4, HS

Family and domain databases

Gene3Di2.20.100.10, 10 hits
InterProiView protein in InterPro
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF00090, TSP_1, 8 hits
SMARTiView protein in SMART
SM00209, TSP1, 16 hits
SUPFAMiSSF82895, SSF82895, 12 hits
PROSITEiView protein in PROSITE
PS50092, TSP1, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHS7B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9C0I4
Secondary accession number(s): E7EM75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 13, 2019
Last modified: August 12, 2020
This is version 109 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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